Hemiplegia
MONDO:0001170Severe or complete loss of motor function on one side of the body. This condition is usually caused by brain diseases that are localized to the cerebral hemisphere opposite to the side of weakness. Less frequently, brain stem lesions; cervical spinal cord diseases; peripheral nervous system diseases; and other conditions may manifest as hemiplegia. The term hemiparesis (see paresis) refers to mild to moderate weakness involving one side of the body.
155 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsSub-types
Broader categories
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Implanted stimulator aims to restore walking after stroke
Disease control OngoingThis study tests an implanted electrical stimulator to improve walking in people who have had a stroke. Six participants will first be screened, then receive the implant and use it at home. Researchers will compare advanced control settings to a simple trigger to see which works …
Phase: NA • Sponsor: MetroHealth Medical Center • Aim: Disease control
Last updated Jun 27, 2026 14:03 UTC
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AI boosts brain scan accuracy in massive new trial
Diagnosis ENROLLING_BY_INVITATIONThis study tests whether an AI tool can help radiologists read brain CT and MRI scans more accurately and quickly. Researchers will compare how well doctors, AI alone, and doctors using AI together can spot abnormalities, urgent findings, and classify diseases. The goal is to red…
Sponsor: Yaou Liu • Aim: Diagnosis
Last updated Jun 27, 2026 11:00 UTC
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Can a digital mirror help kids with One-Sided weakness move better?
Symptom relief OngoingThis study tests two different therapies—digital mirror therapy and action observation therapy—to see which better improves arm movement and grip strength in children with hemiplegia (one-sided weakness). Forty-five children aged 6 to 8 will participate. The goal is to find a sim…
Phase: NA • Sponsor: Cairo University • Aim: Symptom relief
Last updated Jun 27, 2026 14:00 UTC
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New running and skating exercises could help kids with CP move better
Symptom relief OngoingThis study compares a special exercise program called Coordinative Locomotor Training (CLT) to regular physiotherapy for children aged 8 to 12 with spastic hemiplegic cerebral palsy, a condition that causes stiffness on one side of the body. CLT uses running and skating movements…
Phase: NA • Sponsor: University of Faisalabad • Aim: Symptom relief
Last updated Jun 27, 2026 14:00 UTC
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Can a simple leg machine help stiff muscles and walking? new study aims to find out.
Symptom relief ENROLLING_BY_INVITATIONThis study looks at whether using a passive kinesiotherapy device on the legs for 30 minutes can immediately reduce muscle stiffness (spasticity) and improve walking in people with conditions like cerebral palsy, stroke-related weakness, or spinal cord issues. About 80 participan…
Phase: NA • Sponsor: Fernanda Trubian • Aim: Symptom relief
Last updated Jun 27, 2026 12:33 UTC
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Can a robotic shoulder brace help stroke survivors reach and grasp better?
Symptom relief TerminatedThis study tests whether a portable shoulder exoskeleton can help people who had a stroke move their arm and hand better. About 30 participants will perform tasks like reaching and picking up objects with and without the device. The goal is to see if the exoskeleton improves dail…
Phase: NA • Sponsor: University of Idaho • Aim: Symptom relief
Last updated Jun 27, 2026 12:29 UTC
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Fun day camp helps kids with arm weakness move better
Symptom relief ENROLLING_BY_INVITATIONThis study looks at the cost and benefits of a two-week day camp for children with mild to moderate arm weakness (hemiparesis) from cerebral palsy or brain injury. In the first week, children wear a constraint on their stronger arm to encourage use of the weaker arm, followed by …
Phase: NA • Sponsor: University of Calgary • Aim: Symptom relief
Last updated Jun 27, 2026 12:28 UTC
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Shock and flex: new combo therapy aims to restore ankle movement after stroke
Symptom relief OngoingThis study tests whether combining neuromuscular electrical stimulation (NEMS) with voluntary muscle contraction can improve ankle function in people with chronic stroke. Twenty-five participants will either receive conventional physiotherapy or NEMS plus active dorsiflexion exer…
Phase: NA • Sponsor: University of Lahore • Aim: Symptom relief
Last updated Jun 27, 2026 12:06 UTC
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Can a treadmill plus brain games help stroke patients walk again?
Symptom relief OngoingThis study tests a device called GaitBetter that combines treadmill walking with cognitive training (like thinking tasks) to help stroke survivors improve their walking and balance. About 76 people who had a stroke (either within 8 weeks or more than 6 months ago) will use the de…
Phase: NA • Sponsor: Spaulding Rehabilitation Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 12:03 UTC
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New combo therapy aims to ease stroke survivors' muscle tightness and pain
Symptom relief OngoingThis study looks at whether adding tolperison to botulinum toxin injections helps reduce muscle stiffness and nerve pain in stroke survivors. About 40 adults with spastic hemiplegia (one-sided paralysis) will be followed. Researchers will measure spasticity and walking speed to s…
Sponsor: Ayse Guc • Aim: Symptom relief
Last updated Jun 27, 2026 11:03 UTC
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Mirror trick may mend Stroke-Damaged arms
Symptom relief OngoingThis study tests whether mirror therapy can help people who have had a stroke regain movement and reduce pain in a weak arm. Participants do arm exercises while watching the reflection of their good arm, which tricks the brain into thinking the weak arm is moving. The trial invol…
Phase: NA • Sponsor: Mansoura University • Aim: Symptom relief
Last updated Jun 27, 2026 11:02 UTC
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Could a zapping device help stroke survivors swallow again?
Symptom relief ENROLLING_BY_INVITATIONThis study tests whether adding a mild electrical stimulation to the neck muscles can help people who recently had a stroke and now have trouble swallowing. Forty participants will receive either standard swallowing therapy or therapy plus electrical stimulation. The goal is to s…
Phase: NA • Sponsor: Istanbul Arel University • Aim: Symptom relief
Last updated Jun 27, 2026 09:09 UTC
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Nintendo switch exergames tested for stroke rehab
Symptom relief OngoingThis study compares traditional balance exercises with video game-based exergaming (using Nintendo Switch Ring Fit Adventure) in stroke survivors with hemiplegia. Thirty participants will be split into two groups, both receiving standard physiotherapy plus either balance exercise…
Phase: NA • Sponsor: Halic University • Aim: Symptom relief
Last updated Jun 27, 2026 09:08 UTC
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New exercise study aims to help stroke survivors walk and move better
Symptom relief OngoingThis study looks at whether three types of exercises—vestibular rehab, dynamic neuromuscular stabilization, and standard rehab—can improve balance and mobility in people with hemiplegia (paralysis on one side) after a stroke. About 45 adults who had a stroke at least a year ago a…
Phase: NA • Sponsor: Istanbul Medipol University Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 09:01 UTC
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New powered brace aims to help stroke survivors walk better
Symptom relief OngoingThis study tests a device called the Neuromechanical Gait Assist (NMGA) that combines a powered knee brace with muscle stimulation to help people who have difficulty walking after a stroke. Five veterans with leg weakness and a stiff-legged gait will use the device in a lab while…
Phase: NA • Sponsor: VA Office of Research and Development • Aim: Symptom relief
Last updated Jun 27, 2026 07:57 UTC
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Scientists track rare dystonia to map its genetic roots
Knowledge-focused OngoingThis study is observing up to 198 people with rapid-onset dystonia-parkinsonism (RDP) or related genetic mutations. Researchers aim to identify affected individuals, document how common the disease is, and track its progression over time. Participants undergo assessments of sympt…
Sponsor: State University of New York at Buffalo • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:29 UTC
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Shoulder pain may throw off balance in stroke survivors
Knowledge-focused ENROLLING_BY_INVITATIONThis study looks at whether shoulder problems make balance worse for people who have had a stroke and have weakness on one side. Researchers will compare balance in 100 stroke survivors—some with shoulder pain and some without. The goal is to understand if treating shoulder issue…
Sponsor: Istanbul Aydın University • Aim: Knowledge-focused
Last updated Jun 26, 2026 14:55 UTC