Hemicrania continua
MONDO:0018615Hemicrania continua (HC) is a type of primary headache disorder, which means the headache is not caused by another medical condition. Symptoms of HC include constant mild to moderate pain on one side of the head (unilateral) with periods of more intense, severe, migraine -like pain (exacerbations). These severe pain periods can last from 20 minutes to days. The frequency of exacerbations also varies greatly. The headache stays on the same side of the head and usually without pain free periods. HC is more common in women and most often starts in adulthood, but may begin anywhere from 5 to 67 years of age. Diagnosis of hemicrania continua (HC) is made by ruling out other possible causes of the pain and by clinical symptoms. During the periods of severe pain, at least one of the following symptoms must be present on same side of the body as the headache: watering or red eyes (conjunctival injection), congested or runny nose, or drooping eyelid. In addition, the headache pain must respond to treatment with indomethacin. The cause of HC is unknown. Other treatments for those who cannot tolerate long term indomethacin therapy are being studied.
12 clinical trials for this condition and its sub-types.
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Ear needle zaps headaches? new study uses heat cameras to find out
Symptom relief Recruiting nowThis study tests whether inserting a tiny needle into the ear and applying a mild electrical current (called percutaneous needle electrolysis) can help people with frequent headaches. Researchers will use an infrared camera to measure changes in facial skin temperature, since peo…
Phase: NA • Sponsor: University of Alcala • Aim: Symptom relief
Last updated Jun 27, 2026 12:28 UTC
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The eyes as a window to the brain: can a simple scan monitor MS, Alzheimer's, and Parkinson's?
Knowledge-focused Recruiting nowThis study is testing whether a non-invasive eye scan called optical coherence tomography (OCT) can help track neurological diseases like multiple sclerosis, Alzheimer's, Parkinson's, and migraine. Over two years, researchers will measure the thickness of retinal layers in 840 pa…
Sponsor: IRCCS San Raffaele • Aim: Knowledge-focused
Last updated Jul 24, 2026 00:00 UTC
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Massive study aims to unlock secrets of debilitating head pain
Knowledge-focused Recruiting nowThis study is gathering information from 1,500 people with cluster headache or trigeminal neuralgia to learn more about these painful conditions. Researchers will collect surveys, genetic samples, and other health data. The goal is to better understand what causes these headaches…
Sponsor: The University of Texas Health Science Center, Houston • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:06 UTC