Grade II glioma

This study tests a drug called olaparib in people with advanced cancers (like brain tumors, bile duct cancer, or other solid tumors) that have a specific gene change called IDH1 or IDH2 mutation. The drug works by blocking an enzyme that cancer cells need to grow. About 89 partic…

This early-stage trial tests a new type of CAR T-cell therapy designed to target a protein called MMP2 found on glioblastoma cells. The treatment uses a scorpion toxin fragment (chlorotoxin) to help the immune cells find and attack the tumor. Nineteen patients with recurrent or p…

This phase 2 trial tests the drug erdafitinib in 30 adults with a specific type of brain tumor (IDH-wild type glioma) that has come back or is getting worse. The tumor must have a certain gene fusion (FGFR-TACC). Erdafitinib blocks a faulty protein that helps cancer cells grow. T…

This phase 2 trial tests the drug selpercatinib in children and young adults (ages 1 to 21) with advanced cancers that have a specific genetic change called a RET alteration. The goal is to see if the drug can shrink tumors or stop them from growing. Only one participant has been…

This early-stage trial tests a personalized immunotherapy for people with malignant glioma that has returned or not responded to standard treatment. The patient's own T-cells are collected, genetically modified in a lab to recognize and attack glioma cells, and then infused back …

This study tests a drug called tipifarnib in children and young adults (ages 1 to 21) whose cancers have a specific change in the HRAS gene. The cancers are advanced or have come back after treatment. The goal is to see if tipifarnib can shrink tumors or stop them from growing. A…

This phase 2 trial is testing the drug abemaciclib in people whose primary brain tumors have come back after initial treatment. The goal is to see if the drug can shrink tumors or slow their growth. Participants take abemaciclib pills twice daily, and some take it before surgery …

This Phase 3 trial tests whether adding vinblastine to selumetinib works better than selumetinib alone for children and young adults with recurrent or progressive low-grade glioma, a common brain cancer. About 300 participants aged 2 to 25 will be enrolled. The goal is to improve…

This phase 2 trial tested the drug ivosidenib in children and young adults (ages 1 to 21) with solid tumors, lymphomas, or histiocytic disorders that have an IDH1 mutation and have either come back after treatment or not responded. The goal was to see if the drug could shrink or …

This study tests a new drug called DS-1001b in 25 people with a specific type of slow-growing brain tumor (grade II glioma) that has an IDH1 mutation. Participants have not had chemotherapy or radiation before. The goal is to see if the drug can shrink or control the tumor and to…

This early-phase study tests a new drug (BGB-290) combined with chemotherapy (temozolomide) in teens and young adults with a type of brain tumor called glioma that has an IDH mutation. The goal is to find the safest dose and see how well the combination works for both newly diagn…

This study tests a precise type of radiation therapy (IM-SRT) for people with newly diagnosed grade II to IV gliomas. The goal is to deliver a high dose of radiation directly to the tumor while minimizing damage to the scalp, which may reduce wound infections and the need for met…

This early-phase trial is testing whether ketoconazole, a drug normally used for fungal infections, can get into brain tumors (gliomas) in enough amounts to possibly slow their growth. About 80 adults with different grades of glioma will take low doses of the drug before their sc…