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Generalized lipodystrophy

MONDO:0027766

Almost complete absence of subcutaneous and/or visceral adipose tissue.

Also known as: complete generalised lipodystrophy, complete generalized lipodystrophy

11 clinical trials for this condition and its sub-types.

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Sub-types

Congenital generalized lipodystrophy (1) Congenital generalized lipodystrophy type 3 (1) Acquired generalized lipodystrophy (0) Congenital generalized lipodystrophy type 1 (0) Congenital generalized lipodystrophy type 2 (0) Congenital generalized lipodystrophy type 4 (0) Lipodystrophy, congenital generalized, type 5 (0)

Broader categories

Disease (680) Metabolic disease (233) Skin disorder (132) Lipodystrophy (27) Human disease (14) Disease by body system or component (0) Disease by developmental or physiological process (0) Integumentary system disorder (0)

Trials to join now! 4 Not yet finished but already full! 1 Completed 5 Terminated 1

Lifesaving drug made available for rare fat disorder patients

Disease control Ongoing

This study gives the drug metreleptin to people with generalized lipodystrophy, a rare condition that causes severe fat loss and leads to high blood fats and diabetes. Participants, aged 6 months and older, have already received metreleptin in past NIH studies but cannot get it i…

Phase: PHASE3 • Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) • Aim: Disease control

Last updated Jul 19, 2026 00:00 UTC