Generalized lipodystrophy

This study tests the safety of switching from the current drug metreleptin to a new experimental drug called mibavademab in people with generalized lipodystrophy, a rare condition where the body cannot properly store fat. Nine participants who have been stable on metreleptin will…

This study tested an experimental drug called REGN4461 in 16 people with generalized lipodystrophy, a rare condition where the body can't store fat properly, leading to severe metabolic problems. The drug aims to improve blood sugar and triglyceride levels. Participants received …

This study tested the drug spironolactone in 15 adults with chronic right-sided heart failure. The goal was to see if it is safe and can improve heart function and reduce stress on the heart. Participants took either the drug or a placebo to compare effects.

This study looked at the safety of a daily shot called metreleptin (brand name Myalept) in 11 people with generalized lipodystrophy, a rare condition where the body loses fat tissue. The main goal was to see if the body makes antibodies against the drug, which could affect how we…

This study looked for a new gene that causes hereditary lipodystrophy, a rare disease where people lose body fat and often develop diabetes and heart problems. Researchers studied DNA and cells from 2 patients who had the disease but no known genetic cause. The goal was to find t…