Fungal lung infectious disease

This study tests a drug called Sintilimab, which is normally used for cancer, to see if it can help people with HIV who have infections that won't go away with standard treatment. The drug works by 'waking up' exhausted immune cells. Fifty adults with HIV and a hard-to-treat infe…

This study compares two common antibiotic combinations—vancomycin with piperacillin/tazobactam versus vancomycin with meropenem—to see which is less harmful to the kidneys. About 852 hospitalized adults with serious infections will be randomly assigned to one of the two combos. T…

This study looks at which second-choice treatment works best for a serious lung infection called PCP when the usual antibiotic cannot be used due to allergies, side effects, or failure. About 416 adults with weakened immune systems (from HIV, transplants, cancer, or other causes)…

This study tests a drug called liposomal amphotericin B in 40 ICU patients who have a severe fungal infection (invasive aspergillosis) and liver problems. The drug is given daily for 2 weeks, followed by 4 weeks of monitoring. The goal is to see if it is safe and effective for th…

This study looks at how long steroids should be given to adults with severe Pneumocystis pneumonia (PCP), a serious lung infection common in people with weakened immune systems. About 416 participants who improve within 10 days will either stop steroids early or continue for 21 d…

This study tests whether adding corticosteroids (low or moderate dose) to standard care can reduce deaths from severe Pneumocystis pneumonia (PJP) in non-HIV patients in the ICU. PJP has a very high death rate of 60-80% in this group. The trial will compare two steroid doses agai…

This trial tests whether low or moderate doses of the steroid methylprednisolone can reduce deaths in patients with severe community-acquired pneumonia. It will enroll 1500 ICU patients with pneumonia caused by adenovirus or Pneumocystis jirovecii. The study uses an adaptive desi…

This study aims to see if a new blood test (mNGS) can accurately diagnose invasive fungal lung infections in 1,000 people with blood disorders. Participants will provide a blood sample and undergo standard tests, then be followed for 42 days. The goal is to find a faster, more re…

This study tests whether analyzing chemicals in a person's breath can quickly identify serious respiratory infections like COVID-19, flu, and Legionella in hospitalized patients. Researchers will collect breath samples from 777 adults using a simple bag, then analyze them in a la…

This study aims to see if analyzing chemicals in a person's breath can rapidly detect respiratory infections like COVID-19 or the flu. Researchers will collect breath samples from 1,665 adults with symptoms and healthy volunteers. If successful, this non-invasive test could offer…

This study tests whether a rapid PCR test done right in the clinic can help doctors diagnose and treat acute respiratory infections faster. Over 16,000 adults at risk of severe illness will take part. The goal is to see if this approach lowers rates of respiratory failure and hos…

This study tests whether a lower dose of the antibiotic TMP-SMX works as well as the standard dose to prevent a serious lung infection called PJP in people who have just had a kidney transplant. About 1,084 adult first-time kidney transplant recipients will take either a low or s…

This trial tests a handheld light device (RD-X19) to see if using it for 5 minutes every other day can prevent upper respiratory infections like COVID-19 and flu. It involves 130 military personnel and their families at a single base. Half will get the real device, half a sham de…

This study tests whether PMBL® sublingual tablets can reduce the number of respiratory infections (like colds) in children aged 3 to 12 who are prone to getting sick. Half the children will receive the active tablet, and half will receive a placebo (inactive tablet) for 3 months,…

This study tests whether a short course of the steroid prednisolone can prevent paradoxical immune reconstitution inflammatory syndrome (IRIS) in people with AIDS who have low CD4 counts and are starting HIV treatment. About 131 participants will receive either prednisolone or no…

This study tests whether a daily supplement called AHCC, made from shiitake mushrooms, can reduce the number of respiratory infections (like colds) in children aged 2 to 4. Sixty children in daycare will receive either AHCC or a placebo for three months. Researchers will track fe…

This study looks at how well and how safely SIROPSEDAL syrup works for acute cough caused by colds or upper respiratory infections. About 124 children and adults will take the syrup as prescribed by their doctor and report their cough severity over one week. The main goal is to s…

This study compares a new, simpler nerve block method to the traditional one for people having lung surgery with a camera (VATS). The goal is to see if the new method works just as well for pain control and helps patients recover faster. About 200 adults will be randomly assigned…

This study looks at whether watching cartoons or listening to breath-synchronized interactive stories can help children aged 6-9 feel less afraid and more comfortable while using a nebulizer for breathing medication. About 96 children with respiratory conditions will be randomly …

This study looks at whether a fast, bedside test (SPOTFIRE) can help doctors better treat children with respiratory infections in the emergency department. About 720 children aged 2 months to 18 years will be randomly assigned to either get the rapid test or standard care. The go…

This study tests if applying cold (cryotherapy) to the wrist before a blood draw from the artery can reduce pain. It involves 258 adults with chronic respiratory diseases who need this test. The goal is to find a simple, drug-free way to make the procedure less painful.

This observational study will look at 10,000 adults in intensive care units (ICUs) around the world during a single 24-hour period. Researchers want to find out how common infections and antibiotic-resistant bacteria are, how they are treated, and how patients recover. No new tre…

This research project aims to understand why older adults get more infections and why those infections can be more serious. By following 23,000 people aged 60 and older, scientists will collect health data and samples like blood and stool to study how the immune system changes wi…

This study will track which respiratory viruses—like flu, COVID-19, and RSV—are circulating in French primary care clinics each winter. Up to 25,000 patients with cold or flu symptoms will provide a saliva or nose swab sample. The goal is to monitor virus activity and help guide …

This study looks at vitamin D levels in 63 critically ill children (ages 1 month to 12 years) admitted to the ICU with severe breathing infections. Researchers will measure vitamin D in the first 24 hours and compare it to how severe the infection is and the risk of death. The go…

This study looks at how well an inhaled antifungal drug (liposomal amphotericin B) reaches the lungs in people with chronic pulmonary aspergillosis, a long-term lung infection. About 18 adults will inhale two different doses on separate days and then have special scans to see whe…

This study aims to find the best dose of isavuconazole, an antifungal drug, for patients over 60 with invasive fungal infections. Researchers will monitor drug levels in the blood and adjust doses to improve treatment and reduce side effects. The goal is to create personalized do…

This study looks at how different features of an AI system affect the way primary care doctors diagnose and treat respiratory infections. About 3,000 doctors in China will use a web-based tool with various AI features, such as automated data entry or stepwise medication suggestio…

This study will examine gut bacteria, immune markers, and nutrient levels in 120 children with different respiratory health conditions, including pneumonia and recurrent infections, compared to healthy kids. By analyzing stool samples and health data, researchers hope to understa…

This study will collect blood samples from 30,000 adults in the UK with various health conditions, including blood clots, infections, heart disease, diabetes, and more. The samples will be used to develop and fine-tune new diagnostic tests for the cobas® lumira device, which allo…

This study will follow 300 adults with severe infections in the ICU to see how levels of specialized pro-resolving mediators (SPMs)—natural molecules that help stop inflammation—change over time. Researchers will use blood samples already collected during routine care, so no extr…

This study will collect medical information and samples from 300 cancer patients who have or are at risk for a serious fungal infection called mucormycosis. Researchers hope to learn more about how the infection develops and how to better diagnose and manage it. Participants will…

This study will observe 300 children and young adults (ages 0-20) with respiratory tract infections to see if chest ultrasound can predict their outcomes, such as need for hospitalization or ICU care. Researchers will use an ultrasound score and combine it with clinical data to s…