Fatty liver disease

This trial tests whether mazdutide, a weekly injection that targets GLP-1 and glucagon receptors, can safely reduce portal pressure in overweight adults with compensated cirrhosis and clinically significant portal hypertension. Participants receive 16 weeks of mazdutide, with the…

This study tests whether semaglutide (a GLP-1 drug used for diabetes and weight loss) can help people with obesity and fatty liver disease reduce or stop drinking alcohol. 64 participants will receive either semaglutide injections plus lifestyle counseling, or counseling alone. T…

This study tests whether a 12-week program combining a weekly injection of mazdutide (a drug that targets gut hormones) with lifestyle counseling can quickly reduce liver fat in overweight or obese people who want to donate part of their liver but are temporarily disqualified due…

This study will test whether eating a diet rich in whole fruit (up to 50% of daily calories) for 17 weeks can improve blood sugar control, reduce liver fat, and lower heart disease risk in adults with type 2 diabetes who do not use insulin. Participants will eat fruit prepared in…

This study tests whether adding electroacupuncture to a standard diet and medication plan can reduce central obesity and fatty liver in postmenopausal women. Sixty women aged 50-60 with obesity will receive the same diet and orlistat for 12 weeks, but half will also get electroac…

This study tests whether a non-invasive brain stimulation technique called rTMS can reduce liver fat in people with alcohol-related fatty liver disease (MetALD). 105 participants will receive either personalized rTMS, standard rTMS, or a sham (placebo) treatment over 20 sessions.…

This study tests whether a traditional Chinese herbal formula called Longqi Jiangzhi decoction can help treat non-alcoholic fatty liver disease in adults. Eighty participants will take either the herbal medicine or a placebo daily for eight weeks. Researchers will measure liver f…

This study tests whether taking glycine, a natural amino acid, as a daily supplement for 26 weeks can improve liver health in people with metabolic fatty liver disease. Researchers will compare liver fat and blood markers between those taking glycine and those taking a placebo. T…

This study is testing whether a combination of simple, non-invasive tests—like a liver scan and blood samples—can accurately detect advanced liver fibrosis (scarring) in people at risk for fatty liver disease. Researchers will follow 1,200 adults aged 40 to 70 who have obesity, t…

This study tests a near-infrared spectroscopy device that scans the liver with light to diagnose and measure fatty liver disease. Researchers aim to see if it can accurately detect fat levels above 5% and 30%, which are important for liver transplant decisions. The study will inc…

Researchers in South Savo, Finland, invite residents turning 45, 50 or 55 to take a blood test that measures many small molecules at once. The test estimates each person's 10-year risk of type 2 diabetes, heart attack, stroke, chronic kidney disease and fatty liver disease. Peopl…

Researchers at Assiut University are studying whether an underactive thyroid makes liver scarring worse in people with metabolic dysfunction-associated steatotic liver disease (MASLD). The trial enrolls 120 adults with MASLD, half of whom have overt or subclinical hypothyroidism …

This study tests new MRI techniques to measure blood flow and tissue details in the liver. Researchers will scan 110 people, including healthy volunteers and those with chronic liver disease or fibrosis, to see if these scans can reliably detect liver damage. The goal is to devel…

This study looks at how bariatric surgery affects the liver's energy processing in people with obesity and fatty liver disease. Researchers will use safe, non-radioactive tracer infusions and MRI scans before, during, and six months after surgery to measure changes in liver metab…

This study explores whether polycystic ovary syndrome (PCOS) independently contributes to fatty liver disease in adolescent girls, beyond the effects of obesity. Researchers will compare three groups of girls aged 10–18: those with PCOS and obesity, those with obesity alone, and …

This study will check if certain blood-based inflammation markers are linked to fatty liver disease (MASLD) in 100 adults. Participants will have their blood tested and their liver health assessed. The goal is to better understand the role of inflammation in this condition, not t…

This study tests whether two different ultrasound machines can accurately measure liver stiffness and inflammation in people with fatty liver disease. About 95 to 100 adults will take part, including healthy liver donors and patients with fatty liver. The goal is to see if these …

This study will test a two-step screening program for advanced liver fibrosis in people with type 2 diabetes. About 1,714 patients will first get a blood test (FIB-4), and if that suggests risk, they will receive a liver stiffness measurement (transient elastography). The goal is…

This study will check how often fatty liver disease and liver scarring happen in adults with type 1 diabetes or LADA in Quebec. About 100 participants will get a special liver scan (FibroScan) during one visit. The goal is to find hidden liver problems that current checkups might…

This study will test whether a special ultrasound technique can measure liver stiffness and fat as accurately as MRI in people with fatty liver disease. Researchers will compare results from both imaging methods in 145 healthy volunteers and patients. The goal is to find a simple…

This study will screen up to 10,000 adults aged 18-75 who are overweight or have metabolic issues like high blood sugar or cholesterol. Researchers will use questionnaires, blood tests, and liver ultrasounds to find out how common fatty liver disease is and what factors increase …

This study follows 30 people with achalasia (a swallowing disorder) for one year after their treatment. Researchers want to see if the weight gain that often happens after treatment leads to worse metabolic health, like fatty liver or higher blood sugar. Participants will have bl…

This study looks at stored liver biopsy samples from 30 people with MASH (a fatty liver disease) to see if a protein test can predict who will develop liver cancer within 15 years. Half of the participants later got liver cancer, and half did not. Researchers will compare the pro…

This 10-year observational study will follow 10,000 adults with diabetes, metabolic disorders, and related conditions like high blood pressure and fatty liver disease. Researchers will collect routine medical data to identify markers of disease severity and activity. The goal is …