Esophageal varices without bleeding

This study tests whether a Botox injection into the stomach valve works as well as a surgical cut to prevent food from emptying too slowly after esophagus removal. About 170 adults having elective esophagectomy will be randomly assigned to one of the two procedures. Researchers w…

This study tests a new MRI contrast agent called ferumoxytol, made from iron nanoparticles, to see if it can safely and effectively image veins in people with vein diseases. Current dyes can be risky for patients with kidney problems, but ferumoxytol may be safer and last longer …

This study tests a magnetically controlled capsule endoscope—a tiny camera you swallow—to painlessly screen the esophagus and stomach. Researchers will compare different swallowing protocols to see which gives the best view of the Z-line and other areas. 300 patients already sche…

This trial asks whether single-use gastroscopes work as well as standard reusable ones for elective and subacute upper GI procedures. About 300 adults will be examined with either a disposable or a reusable scope, and endoscopists will rate performance on a questionnaire. The stu…

This study compares two techniques—esophageal manometry and EndoFLIP balloon measurements—to evaluate how well they assess swallowing difficulties (dysphagia). Researchers will enroll up to 1,000 patients with known esophageal conditions to see how these measurements relate to sy…