Dyskinesia of esophagus
MONDO:0004729Disorders affecting the motor function of the upper esophageal sphincter; lower esophageal sphincter; the esophagus body, or a combination of these parts. The failure of the sphincters to maintain a tonic pressure may result in gastric reflux of food and acid into the esophagus (gastroesophageal reflux). Other disorders include hypermotility (spastic disorders) and markedly increased amplitude in contraction (nutcracker esophagus).
Also known as: dyskinesia of esophagus, esophageal motility disorder, oesophageal dysmotility, oesophageal motor disorder
27 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsBroader categories
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Simple drug may cut infection risk after major gut surgery
Disease control CompletedThis study tested whether tranexamic acid, a drug that helps blood clot, can lower the chance of infection after gastrointestinal surgery. Over 3,300 adults at higher risk for complications took part. The goal was to see if the drug reduces surgical site infections compared to a …
Phase: PHASE4 • Sponsor: Bayside Health • Aim: Disease control
Last updated Jun 27, 2026 08:07 UTC
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New knife may ease pain after throat surgery for swallowing problems
Symptom relief CompletedThis study compared two different surgical knives used during a procedure called POEM, which treats swallowing disorders by cutting throat muscles. 104 adults were randomly assigned to receive either a standard monopolar knife or a newer bipolar knife (Speedboat-RS2). The goal wa…
Phase: NA • Sponsor: Baylor College of Medicine • Aim: Symptom relief
Last updated Jun 27, 2026 13:05 UTC
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Water vs. gas: which eases pain after esophageal surgery?
Symptom relief CompletedThis study tested if using water instead of carbon dioxide gas during a throat muscle procedure (POEM) could lower pain afterward. 34 adults with swallowing problems took part. The goal was to see which method led to less pain, fewer pain meds, and fewer hospital readmissions.
Phase: NA • Sponsor: AdventHealth • Aim: Symptom relief
Last updated Jun 27, 2026 12:33 UTC
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Can an online wellness program ease anxiety in chronic disease?
Symptom relief CompletedThis study tested a 12-week online mind-body program for adults with chronic conditions like heart failure, cancer, and liver disease. The program included mindful movement, meditation, breathwork, and coping skills. Researchers measured changes in anxiety, depression, fatigue, a…
Phase: NA • Sponsor: University of Alberta • Aim: Symptom relief
Last updated Jun 27, 2026 12:31 UTC
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New hope for preventing Post-Surgery confusion in seniors
Symptom relief CompletedThis study tested whether giving a small amount of s-ketamine during chest surgery could reduce the risk of postoperative delirium (sudden confusion) in patients aged 60 and older. Over 500 participants were randomly assigned to receive either s-ketamine or another drug (dexmedet…
Phase: EARLY_PHASE1 • Sponsor: Affiliated Cancer Hospital & Institute of Guangzhou Medical University • Aim: Symptom relief
Last updated Jun 27, 2026 12:28 UTC
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Botox for the esophagus: new hope for swallowing pain?
Symptom relief CompletedThis study tested whether injecting botulinum toxin (like Botox) into the lower esophagus can ease symptoms of nutcracker esophagus, a condition that causes chest pain and trouble swallowing. Twenty-four adults received either the toxin or a placebo in a double-blind setup. The m…
Phase: PHASE2 • Sponsor: Hospices Civils de Lyon • Aim: Symptom relief
Last updated Jun 27, 2026 08:05 UTC
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Breathing exercises may strengthen key muscle for reflux sufferers
Knowledge-focused CompletedThis study looked at 13 people undergoing a standard esophagus pressure test to see which breathing positions or maneuvers create the highest pressure at the junction between the esophagus and stomach. The goal is to learn how to better contract the diaphragm, which may help with…
Phase: NA • Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:08 UTC