Digestive system neoplasm
MONDO:0021223A neoplasm (disease) that involves the digestive system.
Also known as: GI neoplasm, GI system neoplasm, GI system tumor, GI system tumour, GI tumor, GI tumour, digestive neoplasm, digestive system neoplasm (disease)
8712 clinical trials for this condition and its sub-types, 262 tagged with Digestive system neoplasm itself.
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Sub-types of Digestive system neoplasm
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Digestive system cancer 267 trials · 7,080 incl. sub-types
15 sub-types
- Digestive system carcinoma 25 trials · 4,898 incl. sub-types Sub-types →
- Intestinal cancer 25 trials · 2,791 incl. sub-types Sub-types →
- Liver cancer 255 trials · 1,708 incl. sub-types Sub-types →
- Malignant pancreatic neoplasm 903 trials · 1,450 incl. sub-types Sub-types →
- Gastric cancer 724 trials · 1,035 incl. sub-types Sub-types →
- Esophageal cancer 408 trials · 791 incl. sub-types Sub-types →
- Pharynx cancer 10 trials · 497 incl. sub-types Sub-types →
- Oral cavity cancer 42 trials · 290 incl. sub-types Sub-types →
- Gastroesophageal cancer 157 trials
- Gallbladder cancer 75 trials · 109 incl. sub-types Sub-types →
- Gastrointestinal lymphoma 0 trials · 7 incl. sub-types Sub-types →
- Jaw cancer 1 trial · 5 incl. sub-types Sub-types →
- Digestive system melanoma 0 trials · 2 incl. sub-types Sub-types →
- Malignant tumor of floor of mouth 0 trials · 2 incl. sub-types Sub-types →
- Spleen cancer 0 trials · 2 incl. sub-types Sub-types →
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Intestinal neoplasm 4 trials · 3,080 incl. sub-types
6 sub-types
- Colorectal neoplasm 1,495 trials · 2,900 incl. sub-types Sub-types →
- Intestinal cancer 25 trials · 2,791 incl. sub-types Sub-types →
- Small intestine neoplasm 1 trial · 223 incl. sub-types Sub-types →
- Epithelial tumor of anal canal 0 trials · 34 incl. sub-types Sub-types →
- Intestinal neuroendocrine neoplasm 7 trials · 21 incl. sub-types Sub-types →
- Intestinal benign neoplasm 1 trial · 7 incl. sub-types Sub-types →
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Hepatobiliary neoplasm 26 trials · 1,781 incl. sub-types
2 sub-types
- Liver and intrahepatic bile duct neoplasm 78 trials · 1,752 incl. sub-types Sub-types →
- Gallbladder neoplasm 63 trials · 120 incl. sub-types Sub-types →
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Pancreatic neoplasm 929 trials · 1,579 incl. sub-types
7 sub-types
- Malignant pancreatic neoplasm 903 trials · 1,450 incl. sub-types Sub-types →
- Pancreatic exocrine neoplasm 1 trial · 1,072 incl. sub-types Sub-types →
- Pancreatic neuroendocrine neoplasm 9 trials · 85 incl. sub-types Sub-types →
- Benign neoplasm of pancreas 7 trials Sub-types →
- Adenoma of pancreas 1 trial
- GCGR-related hyperglucagonemia 0 trials
- Intraductal tubulopapillary neoplasm of pancreas 0 trials
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Gastric neoplasm 686 trials · 1,102 incl. sub-types
6 sub-types
- Gastric cancer 724 trials · 1,035 incl. sub-types Sub-types →
- Gastric neuroendocrine neoplasm 3 trials · 6 incl. sub-types Sub-types →
- Gastric adenoma 3 trials Sub-types →
- Benign neoplasm of stomach 1 trial · 2 incl. sub-types Sub-types →
- Gastric hamartomatous polyp 0 trials Sub-types →
- Gastric teratoma 0 trials Sub-types →
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Neoplasm of esophagus 34 trials · 800 incl. sub-types
5 sub-types
- Esophageal cancer 408 trials · 791 incl. sub-types Sub-types →
- Benign neoplasm of esophagus 3 trials Sub-types →
- Esophageal neuroendocrine tumor 1 trial · 3 incl. sub-types Sub-types →
- Esophageal granular cell tumor 0 trials
- Neurofibroma of the esophagus 0 trials
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Pharynx neoplasm 1 trial · 506 incl. sub-types
7 sub-types
- Pharynx cancer 10 trials · 497 incl. sub-types Sub-types →
- Carcinoma of pharynx 3 trials · 457 incl. sub-types Sub-types →
- Neoplasm of oropharynx 3 trials · 280 incl. sub-types Sub-types →
- Nasopharyngeal neoplasm 37 trials · 226 incl. sub-types Sub-types →
- Neoplasm of hypopharynx 0 trials · 100 incl. sub-types Sub-types →
- Tonsil neoplasm 0 trials · 8 incl. sub-types Sub-types →
- Benign neoplasm of pharynx 0 trials Sub-types →
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Oral cavity neoplasm 13 trials · 298 incl. sub-types
3 sub-types
- Oral cavity cancer 42 trials · 290 incl. sub-types Sub-types →
- Palatal neoplasm 0 trials · 2 incl. sub-types Sub-types →
- Benign neoplasm of oral cavity 1 trial Sub-types →
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Digestive system neuroendocrine neoplasm 52 trials · 167 incl. sub-types
7 sub-types
- Digestive system neuroendocrine tumor, grade 1/2 66 trials · 145 incl. sub-types Sub-types →
- Pancreatic neuroendocrine neoplasm 9 trials · 85 incl. sub-types Sub-types →
- Intestinal neuroendocrine neoplasm 7 trials · 21 incl. sub-types Sub-types →
- Gastric neuroendocrine neoplasm 3 trials · 6 incl. sub-types Sub-types →
- Liver neuroendocrine carcinoma 3 trials Sub-types →
- Gallbladder neuroendocrine neoplasm 0 trials Sub-types →
- Salivary gland small cell carcinoma 0 trials
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Digestive system adenoma 0 trials · 127 incl. sub-types
6 sub-types
- Colorectal adenoma 96 trials · 120 incl. sub-types Sub-types →
- Adenoma of small intestine 1 trial · 4 incl. sub-types Sub-types →
- Gastric adenoma 3 trials Sub-types →
- Warthin tumor 1 trial
- Bile duct adenoma 0 trials Sub-types →
- Gallbladder adenoma 0 trials
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Tumor of salivary gland 9 trials · 85 incl. sub-types
4 sub-types
- Salivary gland cancer 62 trials · 81 incl. sub-types Sub-types →
- Neoplasm of major salivary gland 0 trials · 17 incl. sub-types Sub-types →
- Benign neoplasm of salivary gland 1 trial · 5 incl. sub-types Sub-types →
- Neoplasm of minor salivary gland 0 trials Sub-types →
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Benign digestive system neoplasm 0 trials · 41 incl. sub-types
10 sub-types
- Pleomorphic adenoma 12 trials
- Hepatobiliary benign neoplasm 2 trials · 8 incl. sub-types Sub-types →
- Benign neoplasm of pancreas 7 trials Sub-types →
- Intestinal benign neoplasm 1 trial · 7 incl. sub-types Sub-types →
- Benign neoplasm of esophagus 3 trials Sub-types →
- Benign neoplasm of stomach 1 trial · 2 incl. sub-types Sub-types →
- Hepatocellular adenoma 2 trials Sub-types →
- Benign neoplasm of gallbladder 0 trials Sub-types →
- Benign neoplasm of oropharynx 0 trials
- Bile duct papillary neoplasm 0 trials Sub-types →
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Tongue neoplasm 2 trials · 35 incl. sub-types
2 sub-types
- Tongue cancer 26 trials · 35 incl. sub-types Sub-types →
- Benign neoplasm of tongue 0 trials
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Lip neoplasm 1 trial · 15 incl. sub-types
2 sub-types
- Lip cancer 12 trials · 15 incl. sub-types Sub-types →
- Benign neoplasm of lip 0 trials
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Benign epithelial tumor of salivary glands 0 trials · 12 incl. sub-types
1 sub-type
- Pleomorphic adenoma 12 trials
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Neoplasm of jaw 1 trial · 9 incl. sub-types
5 sub-types
- Maxillary neoplasm 4 trials · 6 incl. sub-types Sub-types →
- Jaw cancer 1 trial · 5 incl. sub-types Sub-types →
- Benign neoplasm of lower jaw bone 1 trial Sub-types →
- Neoplasm of retromolar area 0 trials · 1 incl. sub-types Sub-types →
- Congenital epulis 0 trials
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Odontogenic neoplasm 0 trials · 5 incl. sub-types
4 sub-types
- Keratocystic odontogenic tumor 3 trials
- Ameloblastoma 2 trials Sub-types →
- Ameloblastic carcinoma 0 trials
- Calcifying epithelial odontogenic tumor 0 trials
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Malignant epithelial tumor of salivary glands 0 trials · 4 incl. sub-types
1 sub-type
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Gastrointestinal hamartoma 0 trials · 3 incl. sub-types
4 sub-types
- Juvenile polyp 3 trials Sub-types →
- Peutz-Jeghers polyp 0 trials Sub-types →
- Colorectal hamartoma 0 trials Sub-types →
- Gastric hamartomatous polyp 0 trials Sub-types →
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Buccal mucosa neoplasm 0 trials · 2 incl. sub-types
2 sub-types
- Cheek mucosa cancer 1 trial · 2 incl. sub-types Sub-types →
- Benign neoplasm of buccal mucosa 0 trials Sub-types →
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Gingival neoplasm 0 trials · 2 incl. sub-types
3 sub-types
- Gingival cancer 1 trial · 2 incl. sub-types Sub-types →
- Benign neoplasm of gum 0 trials Sub-types →
- Congenital epulis 0 trials
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Neoplasm of floor of mouth 0 trials · 2 incl. sub-types
2 sub-types
- Malignant tumor of floor of mouth 0 trials · 2 incl. sub-types Sub-types →
- Benign neoplasm of floor of mouth 0 trials
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Odontoma 0 trials
Most studied deeper sub-types
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New drug combo shows early promise against Hard-to-Treat cancers
Disease control Stopped earlyThis early-stage study tested a new drug called BI 765049, alone or combined with another drug (ezabenlimab), in 21 Asian adults with advanced solid tumors (stomach, colorectal, pancreatic, liver, head and neck, or lung cancer) that have a specific marker called B7-H6. The main g…
Phase 1 • Sponsor: Boehringer Ingelheim • Aim: Disease control
Last updated Aug 29, 2026 00:00 UTC
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Quitting before the knife: which Stop-Smoking aid works best for cancer patients?
Disease control Stopped earlyThis trial explores whether adding counseling, cognitive behavioural therapy, or hypnotherapy to nicotine replacement therapy can help cancer patients quit smoking before their surgery. The study includes adults with breast, digestive, gynecologic cancer, or melanoma who smoke da…
Sponsor: Institut Cancerologie de l'Ouest • Aim: Disease control
Last updated Aug 09, 2026 00:00 UTC
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Brain cancer trial halted early: can Memory-Sparing radiation help when tumors return?
Disease control Stopped earlyThis phase III trial compared two radiation strategies for cancer that had spread to the brain and returned in new spots after initial radiosurgery. One group received focused radiation only to the new tumors, while the other received whole brain radiation that avoided the memory…
Phase 3 • Sponsor: NRG Oncology • Aim: Disease control
Last updated Jun 27, 2026 12:35 UTC
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Experimental cell therapy targets tough cancers, but trial ends early
Disease control Stopped earlyThis early-phase trial tested a new approach: taking a patient's own white blood cells, genetically modifying them in the lab to recognize a specific cancer mutation (KRAS G12D), and infusing them back to attack tumors. The study enrolled only 5 adults with advanced gastrointesti…
Phase 1/2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 27, 2026 12:35 UTC
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New blood thinner tested for cancer Patients' clots – study halted early
Disease control Stopped earlyThis phase 3 trial tested a new drug, abelacimab, against a standard blood thinner (dalteparin) to prevent dangerous blood clots from returning in people with gastrointestinal or genitourinary cancers. The study enrolled 417 adults with advanced cancer and a recent clot. It was t…
Phase 3 • Sponsor: Anthos Therapeutics, Inc. • Aim: Disease control
Last updated Jun 27, 2026 12:08 UTC
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Short nutrition boost before cancer surgery: does it help?
Disease control Stopped earlyThis study looked at whether giving well-nourished people with gastrointestinal cancer a special nutrition drink for 3 days before surgery could reduce complications and shorten hospital stays. The trial was stopped early, so results are limited. It involved 107 adults with stoma…
Sponsor: Société des Produits Nestlé (SPN) • Aim: Disease control
Last updated Jun 27, 2026 08:03 UTC
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New targeted drug shows promise for Hard-to-Treat stomach cancers
Disease control Stopped earlyThis early-phase trial tested a new drug called EO-3021, which targets a protein (CLDN18.2) found on some cancer cells. The study included 88 adults with advanced stomach or gastrointestinal cancers that had not responded to standard treatments. Participants received EO-3021 alon…
Phase 1 • Sponsor: Elevation Oncology • Aim: Disease control
Last updated Jun 27, 2026 07:57 UTC
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Cancer combo trial halted early: what we know
Disease control Stopped earlyThis phase 2 trial tested two drugs—ulixertinib and hydroxychloroquine—in 47 people with advanced gastrointestinal cancers that have certain genetic mutations (MAPK pathway). The goal was to see if the combination could shrink tumors. However, the study was terminated early, so t…
Phase 2 • Sponsor: BioMed Valley Discoveries, Inc • Aim: Disease control
Last updated Jun 27, 2026 07:51 UTC
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Experimental cancer combo trial halted early – what it means for patients
Disease control Stopped earlyThis early-stage trial tested a new drug called BDC-1001, alone or with the immunotherapy nivolumab, in 175 people with advanced HER2-positive cancers (like breast, colorectal, and stomach cancers) that had stopped responding to other treatments. The study aimed to check safety a…
Phase 1/2 • Sponsor: Bolt Biotherapeutics, Inc. • Aim: Disease control
Last updated Jun 26, 2026 17:13 UTC