Digestive system cancer
MONDO:0002516A primary or metastatic malignant neoplasm involving any part of the digestive system.
Also known as: GI tumor, GI tumour, cancer of digestive system, digestive system cancer, gastrointestinal system cancer, malignant digestive system neoplasm, malignant gastrointestinal neoplasm, malignant gastrointestinal system neoplasm
9498 clinical trials for this condition and its sub-types, 267 tagged with Digestive system cancer itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Digestive system cancer
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Digestive system carcinoma 25 trials · 4,898 incl. sub-types
16 sub-types
- Carcinoma of liver and intrahepatic biliary tract 36 trials · 1,461 incl. sub-types Sub-types →
- Colorectal carcinoma 305 trials · 1,170 incl. sub-types Sub-types →
- Exocrine pancreatic carcinoma 205 trials · 1,037 incl. sub-types Sub-types →
- Gastric carcinoma 92 trials · 555 incl. sub-types Sub-types →
- Carcinoma of esophagus 76 trials · 509 incl. sub-types Sub-types →
- Gastroesophageal junction adenocarcinoma 507 trials
- Carcinoma of pharynx 3 trials · 457 incl. sub-types Sub-types →
- Oral cavity carcinoma 16 trials · 202 incl. sub-types Sub-types →
- Small intestine carcinoma 19 trials · 105 incl. sub-types Sub-types →
- Gallbladder carcinoma 41 trials · 49 incl. sub-types Sub-types →
- Intestine carcinoma in situ 0 trials · 16 incl. sub-types Sub-types →
- Pancreatic endocrine carcinoma 12 trials Sub-types →
- Digestive system mixed adenoneuroendocrine carcinoma 0 trials · 3 incl. sub-types Sub-types →
- Carcinoma of floor of mouth 1 trial · 2 incl. sub-types Sub-types →
- Maxillary sinus carcinoma 1 trial · 2 incl. sub-types Sub-types →
- Ameloblastic carcinoma 0 trials
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Intestinal cancer 25 trials · 2,791 incl. sub-types
6 sub-types
- Colorectal cancer 1,770 trials · 2,702 incl. sub-types Sub-types →
- Small intestine cancer 8 trials · 118 incl. sub-types Sub-types →
- Anal canal cancer 22 trials · 44 incl. sub-types Sub-types →
- Intestine carcinoma in situ 0 trials · 16 incl. sub-types Sub-types →
- Colorectal Kaposi sarcoma 0 trials Sub-types →
- Gastric intestinal type adenocarcinoma 0 trials
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Liver cancer 255 trials · 1,708 incl. sub-types
5 sub-types
- Carcinoma of liver and intrahepatic biliary tract 36 trials · 1,461 incl. sub-types Sub-types →
- Biliary tract cancer 244 trials · 618 incl. sub-types Sub-types →
- Liver sarcoma 1 trial · 10 incl. sub-types Sub-types →
- Liver lymphoma 1 trial Sub-types →
- Calcifying nested epithelial stromal tumor of the liver 0 trials
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Malignant pancreatic neoplasm 903 trials · 1,450 incl. sub-types
4 sub-types
- Malignant exocrine pancreas neoplasm 4 trials · 1,057 incl. sub-types Sub-types →
- Pancreatic endocrine carcinoma 12 trials Sub-types →
- Pancreas lymphoma 0 trials Sub-types →
- Pancreas sarcoma 0 trials
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Gastric cancer 724 trials · 1,035 incl. sub-types
9 sub-types
- Gastric carcinoma 92 trials · 555 incl. sub-types Sub-types →
- Cardia cancer 0 trials · 7 incl. sub-types Sub-types →
- Diffuse gastric cancer 3 trials
- Gastric lymphoma 1 trial · 3 incl. sub-types Sub-types →
- Gastric leiomyosarcoma 0 trials
- Gastric liposarcoma 0 trials
- Malignant gastric germ cell tumor 0 trials Sub-types →
- Malignant gastric granular cell tumor 0 trials
- Pylorus cancer 0 trials Sub-types →
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Esophageal cancer 408 trials · 791 incl. sub-types
7 sub-types
- Carcinoma of esophagus 76 trials · 509 incl. sub-types Sub-types →
- Malignant neoplasm of thoracic esophagus 3 trials
- Esophageal melanoma 1 trial
- Malignant neoplasm of cervical esophagus 1 trial
- Esophagus lymphoma 0 trials
- Esophagus sarcoma 0 trials Sub-types →
- Malignant neoplasm of abdominal esophagus 0 trials
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Pharynx cancer 10 trials · 497 incl. sub-types
5 sub-types
- Oropharynx cancer 150 trials · 280 incl. sub-types Sub-types →
- Malignant tumor of nasopharynx 9 trials · 214 incl. sub-types Sub-types →
- Pharyngeal squamous cell carcinoma 5 trials · 203 incl. sub-types Sub-types →
- Hypopharynx cancer 50 trials · 100 incl. sub-types Sub-types →
- Pharyngeal adenoid cystic carcinoma 0 trials
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Oral cavity cancer 42 trials · 290 incl. sub-types
11 sub-types
- Oral cavity carcinoma 16 trials · 202 incl. sub-types Sub-types →
- Salivary gland cancer 62 trials · 81 incl. sub-types Sub-types →
- Tongue cancer 26 trials · 35 incl. sub-types Sub-types →
- Lip cancer 12 trials · 15 incl. sub-types Sub-types →
- Cheek mucosa cancer 1 trial · 2 incl. sub-types Sub-types →
- Gingival cancer 1 trial · 2 incl. sub-types Sub-types →
- Hard palate cancer 0 trials · 1 incl. sub-types Sub-types →
- Retromolar area cancer 1 trial
- Soft palate cancer 0 trials · 1 incl. sub-types Sub-types →
- Oral rhabdomyosarcoma 0 trials
- Vestibule of mouth cancer 0 trials Sub-types →
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Gastroesophageal cancer 157 trials
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Gallbladder cancer 75 trials · 109 incl. sub-types
5 sub-types
- Gallbladder carcinoma 41 trials · 49 incl. sub-types Sub-types →
- Gallbladder melanoma 1 trial
- Gallbladder lymphoma 0 trials
- Gallbladder sarcoma 0 trials Sub-types →
- Neurofibroma of gallbladder 0 trials
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Gastrointestinal lymphoma 0 trials · 7 incl. sub-types
10 sub-types
- Gastric lymphoma 1 trial · 3 incl. sub-types Sub-types →
- Small intestine lymphoma 3 trials Sub-types →
- Liver lymphoma 1 trial Sub-types →
- Colorectal lymphoma 0 trials Sub-types →
- Esophagus lymphoma 0 trials
- Gallbladder lymphoma 0 trials
- Pancreas lymphoma 0 trials Sub-types →
- Splenic manifestation of hairy cell leukemia 0 trials
- Splenic manifestation of prolymphocytic leukemia 0 trials
- Tonsillar lymphoma 0 trials
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Jaw cancer 1 trial · 5 incl. sub-types
3 sub-types
- Maxillary sinus carcinoma 1 trial · 2 incl. sub-types Sub-types →
- Mandibular cancer 1 trial
- Retromolar area cancer 1 trial
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Digestive system melanoma 0 trials · 2 incl. sub-types
3 sub-types
- Rectum malignant melanoma 1 trial · 2 incl. sub-types Sub-types →
- Esophageal melanoma 1 trial
- Gallbladder melanoma 1 trial
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Malignant tumor of floor of mouth 0 trials · 2 incl. sub-types
1 sub-type
- Carcinoma of floor of mouth 1 trial · 2 incl. sub-types Sub-types →
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Spleen cancer 0 trials · 2 incl. sub-types
5 sub-types
- Gastric mucosa-associated lymphoid tissue lymphoma 2 trials
- Small intestinal mucosa-associated lymphoid tissue lymphoma 0 trials
- Spleen angiosarcoma 0 trials
- Splenic manifestation of leukemia 0 trials Sub-types →
- Tonsillar lymphoma 0 trials
Most studied deeper sub-types
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Can a new drug shrink Hard-to-Treat digestive tumors?
Disease control Not yet recruitingThis study tests an experimental drug called BL-M08D1 in adults with advanced or metastatic digestive tract tumors and other solid tumors. The goal is to find the best dose and see how well it shrinks tumors and slows disease progression. Participants receive the drug by intraven…
Phase 1/2 • Sponsor: Sichuan Baili Pharmaceutical Co., Ltd. • Aim: Disease control
Last updated Aug 29, 2026 00:00 UTC
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Can a new infusion drug shrink Hard-to-Treat tumors?
Disease control Not yet recruitingThis early-stage trial is testing an investigational drug called BL-ARC002 in people with advanced gastrointestinal or other solid tumors that have spread. The main goals are to find a safe dose and to see if the drug shows any signs of shrinking tumors. Participants receive the …
Phase 1 • Sponsor: Sichuan Baili Pharmaceutical Co., Ltd. • Aim: Disease control
Last updated Aug 29, 2026 00:00 UTC
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Personalized cell therapy takes on GI cancers
Disease control Not yet recruitingThis study tests a new treatment for gastrointestinal cancer using a patient's own immune cells, which are engineered in a lab to target cancer. About 100 participants will receive these cells to see if they are safe and can shrink tumors. The trial is currently recruiting and co…
Phase 1/2 • Sponsor: Shenzhen Geno-Immune Medical Institute • Aim: Disease control
Last updated Aug 28, 2026 00:00 UTC
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A future without surgery for stomach and colon cancers?
Disease control Not yet recruitingThis study tests whether people with certain gastrointestinal cancers—like stomach, esophageal, or colorectal—can safely skip radical surgery after responding well to precision therapies such as immunotherapy or targeted drugs. Participants with specific molecular markers will be…
Sponsor: Peking University Cancer Hospital & Institute • Aim: Disease control
Last updated Aug 22, 2026 00:00 UTC
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Can a Patient's own immune cells be trained to fight advanced GI cancers?
Disease control Not yet recruitingThis early trial is testing an experimental cell therapy called cCTL-GL01 in people with advanced stomach, esophageal, colon, or rectal cancers that have not responded to standard treatments. The therapy uses a patient's own immune cells, which are specially trained in the lab to…
Phase 1 • Sponsor: The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School • Aim: Disease control
Last updated Jul 31, 2026 00:00 UTC
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New care model aims to close cancer treatment gaps for people with mental illness
Disease control Not yet recruitingThis trial tests a 24-week virtual care program called BRIDGE NET for people with serious mental illness who are starting cancer treatment. The program brings together oncology and mental health teams to plan care, provide early psychiatric support, and regularly check in with pa…
Sponsor: Massachusetts General Hospital • Aim: Disease control
Last updated Jul 18, 2026 00:00 UTC
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Immunotherapy may let some GI cancer patients skip the knife
Disease control Not yet recruitingThis study looks at whether immunotherapy can shrink certain gastrointestinal cancers (like colorectal or stomach cancer) enough that some patients may not need major surgery. People whose tumors have specific genetic features (MSI-H/dMMR or POLE mutation) and who respond well to…
Sponsor: Peking University Cancer Hospital & Institute • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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Could some GI cancer patients avoid major surgery? new study explores organ preservation
Disease control Not yet recruitingThis study looks at whether people with certain genetic types of gastrointestinal cancers (stomach, colorectal, or anal) can safely avoid major surgery after immunotherapy. Instead of removing the organ, doctors will monitor closely or do smaller procedures to remove any remainin…
Sponsor: Peking University Cancer Hospital & Institute • Aim: Disease control
Last updated Jun 27, 2026 13:07 UTC
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Pre-Surgery boot camp may slash cancer surgery risks
Disease control Not yet recruitingThis study tests whether a 4-week program of high-intensity interval training, specialized nutrition, and psychological support before major gastrointestinal cancer surgery can lower the risk of serious complications afterward. About 400 high-risk patients will be randomly assign…
Sponsor: University Hospital of Cologne • Aim: Disease control
Last updated Jun 27, 2026 09:05 UTC
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Could early palliative care reduce aggressive End-of-Life cancer treatments?
Symptom relief Not yet recruitingThis study looks at whether bringing in palliative care early during an unplanned hospital stay can reduce aggressive treatments at the end of life for people with advanced cancer. About 493 adults with metastatic digestive, gynecological, ENT, or sarcoma cancers will be randomly…
Sponsor: Centre Oscar Lambret • Aim: Symptom relief
Last updated Sep 19, 2026 00:00 UTC
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Yogurt as medicine? Butyrate-Rich formula tested for Cancer-Related constipation
Symptom relief Not yet recruitingThis phase II trial investigates whether a specially formulated yogurt rich in butyrate—a short-chain fatty acid—can relieve constipation in people with gastrointestinal cancer. Constipation is a common and distressing side effect of cancer and its treatments, and current medicat…
Phase 2 • Sponsor: Tianjin Medical University Cancer Institute and Hospital • Aim: Symptom relief
Last updated Jul 25, 2026 00:00 UTC
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Smartphone app aims to uncover food triggers for gut cancer survivors
Symptom relief Not yet recruitingThis study tests a mobile app called GutCheck for people who have survived gastrointestinal cancer. Participants track their diet, stress, and gut symptoms daily. The app analyzes the data to identify potential trigger foods. The goal is to see if the app is feasible and helpful …
Sponsor: Masonic Cancer Center, University of Minnesota • Aim: Symptom relief
Last updated Jun 27, 2026 14:01 UTC
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No opioids, less confusion? new study for seniors having gut surgery
Symptom relief Not yet recruitingThis study looks at whether using a drug combination without opioids during anesthesia can lower the chance of confusion (delirium) after surgery in people 65 and older having gastrointestinal surgery. About 174 participants will be randomly assigned to receive either opioid-free…
Phase 1 • Sponsor: Qianfoshan Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 12:36 UTC
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Could zapping the spleen fix Chemo's side effect?
Symptom relief Not yet recruitingThis pilot study tests a new use of targeted radiation (SIRT) to the spleen in 18 adults with gastrointestinal cancer who have low platelets and an enlarged spleen from chemotherapy. The goal is to see if the procedure is safe and can raise platelet counts, helping patients stay …
Sponsor: Centre Georges Francois Leclerc • Aim: Symptom relief
Last updated Jun 27, 2026 12:34 UTC
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New study tests nutritional supplement to tame chemo side effects
Symptom relief Not yet recruitingThis study tests whether a special nutritional supplement (LH BLU) can reduce serious side effects in people with advanced gastrointestinal cancers who are starting chemotherapy. About 88 participants will either receive the supplement plus nutritional counseling or just counseli…
Sponsor: IRCCS San Raffaele • Aim: Symptom relief
Last updated Jun 27, 2026 12:33 UTC
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Could silkworm pupas be the key to fighting muscle loss in cancer survivors?
Symptom relief Not yet recruitingThis study tests whether silkworm pupa tablets can improve nutrition and reduce muscle loss (sarcopenia) in people who have completed cancer treatment. 480 participants will receive either the tablets or a placebo for 3 months. The main goal is to see if muscle strength and mass …
Phase 3 • Sponsor: First Affiliated Hospital of Zhejiang University • Aim: Symptom relief
Last updated Jun 27, 2026 12:24 UTC
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Can artificial intelligence think like a cancer tumor board?
Knowledge-focused Not yet recruitingThis study asks whether an artificial intelligence system can make the same care recommendations as a team of cancer experts for people with stomach, colon, or rectal cancer. About 69 participants will have their medical information reviewed independently by both the AI and a mul…
Sponsor: Shanghai Minimally Invasive Surgery Center • Aim: Knowledge-focused
Last updated Aug 07, 2026 00:00 UTC
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New program aims to make cancer surgery safer for seniors
Knowledge-focused Not yet recruitingThis study looks at how a special program, called the Geriatric Surgery Verification Program, works at the James Cancer Hospital. The program helps doctors and nurses better care for patients aged 65 and older who need cancer surgery. It includes checking for age-related issues l…
Sponsor: Ohio State University Comprehensive Cancer Center • Aim: Knowledge-focused
Last updated Jul 25, 2026 00:00 UTC
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Can a digital Pre-Surgery boost help cancer patients recover faster?
Knowledge-focused Not yet recruitingThis study tests whether a digitally supported prehabilitation program is feasible for patients awaiting major surgery for cancers of the pancreas, liver, stomach, or esophagus. The program includes supervised exercise, nutritional counseling, psychological support, and digital t…
Sponsor: Ludwig Boltzmann Institute for Digital Health and Prevention • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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Massive cancer registry aims to unlock better GI cancer care
Knowledge-focused Not yet recruitingThis study is a registry that collects medical information and biological samples from up to 100,000 people with gastrointestinal cancers, such as pancreatic or colorectal cancer. No new treatments or drugs are given. The goal is to gather real-world data to help researchers answ…
Sponsor: Canopy Cancer Collective, LLC • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:37 UTC
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Genetic risk profiles could change how we monitor Barrett's esophagus
Knowledge-focused Not yet recruitingThis study looks at whether sharing genetic risk information with Barrett's esophagus patients can improve their quality of life and reduce cancer worry. Researchers will collect tissue samples and use genetic analysis to create risk profiles. Half of the 266 participants will le…
Sponsor: University Hospital, Antwerp • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:10 UTC
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New study aims to predict which cancer patients struggle most with eating
Knowledge-focused Not yet recruitingThis study looks at how cancer and its treatments change the way people experience food, including taste, mouth health, and overall eating pleasure. Researchers will ask 180 adults with different cancers to fill out a detailed questionnaire about their eating habits and feelings.…
Sponsor: Hospices Civils de Lyon • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:09 UTC
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AI could help decide when You're ready to recover after surgery
Knowledge-focused Not yet recruitingAfter gastrointestinal or cancer surgery, it's hard to know when it's safe to start rehabilitation. This study tests an AI tool that analyzes hospital data to predict which patients are ready for early rehab. The tool gives a simple yes/no answer to help doctors decide. The study…
Sponsor: Erasmus Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:04 UTC
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New study to track pain relief in abdominal and pelvic cancer patients
Knowledge-focused Not yet recruitingThis study will observe 100 adults with chronic pain from abdominal or pelvic cancer to see how effective pain management interventions are. Researchers will track pain scores using a 0-10 scale and note any side effects or complications. The goal is to understand what works best…
Sponsor: Aga Khan University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:12 UTC
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New study aims to predict bleeding and clotting risks in cancer patients
Knowledge-focused Not yet recruitingThis observational study will measure how well the body breaks down blood clots in 150 cancer patients (with blood cancers or solid tumors) who also have clotting issues. Researchers will take extra blood samples during routine care to look for markers that might predict bleeding…
Sponsor: University Hospital, Strasbourg, France • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:03 UTC
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Gut bacteria may hold key to better nutrition for cancer patients
Knowledge-focused Not yet recruitingThis study looks at how the bacteria in the gut and mouth relate to nutrition in 150 adults with digestive cancer starting chemotherapy. Researchers will collect stool and saliva samples, along with questionnaires and tests, before and after the first chemo cycle. The goal is to …
Sponsor: Hospices Civils de Lyon • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:01 UTC
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Simple Pre-Surgery steps could boost stoma Patients' quality of life
Knowledge-focused Not yet recruitingThis study will follow 100 people who need a stoma (an opening in the belly to pass stool) after surgery. Some will have their stoma site marked and get education before surgery, while others will not. The goal is to see if these steps improve quality of life and reduce problems …
Sponsor: Assistance Publique Hopitaux De Marseille • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:57 UTC
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Kidney trouble may skew chemo safety test – new study aims to fix that
Knowledge-focused Not yet recruitingThis study looks at whether kidney problems interfere with a common blood test used to check how well patients break down certain chemotherapy drugs (fluoropyrimidines). Researchers will measure DPD enzyme activity in about 742 people with breast or digestive cancer, kidney failu…
Sponsor: Centre Hospitalier Universitaire de Besancon • Aim: Knowledge-focused
Last updated Jun 26, 2026 18:38 UTC
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Real-world test of adebrelimab combo for tough cancers
Knowledge-focused Not yet recruitingThis study will observe 300 people with advanced lung or gastrointestinal cancers who receive adebrelimab combined with other treatments. Researchers will track side effects and how well the cancer responds. It is a real-world study, meaning it watches what happens in regular med…
Sponsor: Tianjin First Central Hospital • Aim: Knowledge-focused
Last updated Jun 26, 2026 17:13 UTC