Could zapping the spleen fix Chemo's side effect?

NCT ID NCT07575854

Not yet recruiting Symptom relief Sponsor: Centre Georges Francois Leclerc Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This pilot study tests a new use of targeted radiation (SIRT) to the spleen in 18 adults with gastrointestinal cancer who have low platelets and an enlarged spleen from chemotherapy. The goal is to see if the procedure is safe and can raise platelet counts, helping patients stay on their cancer treatment. The study will also find the highest safe radiation dose.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Yttrium-90 glass microspheres (TheraSphere) delivered via radiation procedure
What this could lead to: If it works, this could offer a new way to manage chemotherapy-induced low platelets, allowing patients to continue cancer treatment without delays.
What could go wrong: This is a very early, small pilot study with only 18 participants, so results may not apply broadly. The radiation procedure carries risks like bleeding, infection, or damage to nearby organs.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

digestive system cancer digestive system neoplasm Splenomegaly

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GASTROINTESTINAL CANCER

Contacts and locations

Locations

CHU Saint Eloi

Montpellier, 34295, France
Centre Eugène Marquis

Rennes, 35042, France
Centre Georges-François Leclerc

Dijon, 21000, France
Institut Gustave Roussy

Villejuif, 94800, France

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