Diabetes insipidus
MONDO:0004782A disorder characterized by excretion of large amounts of urine, accompanied by excessive thirst. Causes include deficiency of antidiuretic hormone or failure of the kidneys to respond to antidiuretic hormone. It may also be drug-related.
43 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsSub-types
Broader categories
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Triple-Drug cocktail for septic shock shows promise in small trial
Disease control CompletedThis study tested whether giving three blood-pressure-raising drugs (norepinephrine, angiotensin II, and vasopressin) together early in septic shock works better than the usual stepwise approach. Researchers enrolled 79 adults with severe sepsis and low blood pressure despite flu…
Phase: PHASE2, PHASE3 • Sponsor: University Medical Centre Maribor • Aim: Disease control
Last updated Jun 27, 2026 12:01 UTC
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Extra water daily may curb high blood sugar
Disease control CompletedThis study tested whether drinking an extra 1.5 liters of water daily for a year could lower blood sugar in adults with signs of dehydration and high blood glucose. Nearly 800 participants were split into two groups: one received lifestyle advice plus extra water, the other only …
Phase: NA • Sponsor: Region Skane • Aim: Disease control
Last updated Jun 27, 2026 08:01 UTC
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Sweat sensor could replace needles for kidney patients
Diagnosis CompletedThis study tested a new wearable patch that collects sweat to measure sodium and creatinine levels, which are important for monitoring kidney health and dehydration. Five adults with kidney disease wore the patch while their sweat was analyzed using a special light-based techniqu…
Phase: NA • Sponsor: Korea University • Aim: Diagnosis
Last updated Jun 27, 2026 08:11 UTC
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Sugar alcohol infusion may help diagnose thirst disorders
Diagnosis CompletedThis study tested whether infusing mannitol, a sugar alcohol, can help diagnose polyuria-polydipsia syndrome—a condition of excessive thirst and urination. Researchers measured copeptin levels in 42 healthy adults and patients after mannitol or placebo infusion. The goal was to s…
Phase: NA • Sponsor: University Hospital, Basel, Switzerland • Aim: Diagnosis
Last updated Jun 27, 2026 08:04 UTC
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New drug PB shows promise for slowing excessive urination in kidney patients
Symptom relief CompletedThis study tested whether the medication PB can safely reduce excessive urination in people with certain kidney diseases, including inherited nephrogenic diabetes insipidus, lithium-induced diabetes insipidus, and polycystic kidney disease treated with tolvaptan. Researchers meas…
Phase: PHASE2 • Sponsor: Mayo Clinic • Aim: Symptom relief
Last updated Jun 27, 2026 09:00 UTC
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Stress-Busting program for nurses shows promise
Symptom relief CompletedThis study tested a 4.5-hour somatic psychoeducational program for healthcare providers to see if it could improve their mental and physical health. Thirty-one bedside nurses participated, completing surveys and saliva tests before, one week after, and one month after the program…
Phase: NA • Sponsor: University of Florida • Aim: Symptom relief
Last updated Jun 27, 2026 07:56 UTC
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Can estrogen boost the 'Love Hormone' in a rare condition?
Knowledge-focused CompletedThis pilot study tested whether a single dose of oral estrogen-progestin can raise oxytocin levels in people with arginine vasopressin deficiency (AVD), a rare condition that also causes low oxytocin. Researchers compared 28 adults—some with AVD and some healthy—to see if oxytoci…
Phase: EARLY_PHASE1 • Sponsor: Elizabeth Austen Lawson • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:33 UTC
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Can a diabetes drug reveal hidden hormone deficiencies?
Knowledge-focused CompletedThis study tested whether people with hypopituitarism (a condition where the pituitary gland doesn't work properly) have lower oxytocin levels compared to healthy individuals. Researchers gave participants a drug called exenatide (a GLP1 receptor agonist) to see if it could stimu…
Phase: PHASE4 • Sponsor: Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:13 UTC
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Love hormone study reveals brain wave secrets
Knowledge-focused CompletedThis study looked at how two natural brain chemicals, oxytocin and vasopressin, change the way brain waves interact. 120 healthy adults received nasal sprays of these chemicals and had their brain activity measured with EEG. The goal was to understand basic brain function, not to…
Phase: NA • Sponsor: University of Electronic Science and Technology of China • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:53 UTC