Corneal ulcer
MONDO:0004577Area of epithelial tissue loss from corneal surface; associated with inflammatory cells in the cornea and anterior chamber.
Also known as: Ulcer, corneal, cornea ulcer disease, ulcer disease of cornea
23 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsSub-types
Broader categories
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New membrane could speed healing of eye infections
Disease control CompletedThis study tested whether adding a special amniotic membrane containing riboflavin and moxifloxacin to standard PACK-CXL therapy helps heal infected corneal ulcers faster. 32 adults with moderate-to-severe ulcers took part. The goal was to see if the membrane improves corneal hea…
Phase: PHASE2 • Sponsor: Gadjah Mada University • Aim: Disease control
Last updated Jun 27, 2026 12:26 UTC
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Green light and pink dye take on tough eye infections
Disease control CompletedThis study tested whether adding a light-activated dye (rose bengal) to standard antibiotic or antifungal eye drops could improve vision in people with severe corneal infections. About 330 adults in India and Brazil with fungal or amoeba infections received either standard drops …
Phase: PHASE3 • Sponsor: University of California, San Francisco • Aim: Disease control
Last updated Jun 27, 2026 09:00 UTC
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Eye injection shows promise against fungal ulcers
Disease control CompletedThis study tested whether adding an injection of the antifungal drug voriconazole into the eye could improve treatment for fungal corneal ulcers. 70 people with moderate to severe infections received either standard antifungal drops alone or drops plus three injections over 10 da…
Phase: PHASE3 • Sponsor: University of California, San Francisco • Aim: Disease control
Last updated Jun 27, 2026 07:52 UTC
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New eye scanner could sharpen diagnosis of glaucoma and retina diseases
Diagnosis CompletedThis study is testing a new eye imaging device called the VG200D, which uses advanced technology to take detailed pictures of the eye. Researchers want to see if it works as well as a standard device for measuring parts of the eye in people with glaucoma, retina problems, corneal…
Sponsor: Intalight, Inc • Aim: Diagnosis
Last updated Jul 31, 2026 00:00 UTC
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New eye insert may ease pain after cataract surgery
Symptom relief CompletedThis study tested whether a tiny eye insert called DEXTENZA, placed after cataract surgery, works better than standard eye drops alone for reducing pain and swelling. Fifty adults having cataract surgery took part. The insert slowly releases medicine over time, aiming to improve …
Phase: PHASE4 • Sponsor: Nicole Fram M.D. • Aim: Symptom relief
Last updated Jun 27, 2026 09:07 UTC
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Stem cell eye drops show promise for Hard-to-Treat corneal damage
Symptom relief CompletedThis early-stage study tested the safety of eye drops made from stem cell secretions in 9 adults with chronic corneal surface disease that did not improve with standard treatments. The drops were given in increasing doses to find the safest amount. Researchers checked for side ef…
Phase: EARLY_PHASE1 • Sponsor: University of Illinois at Chicago • Aim: Symptom relief
Last updated Jun 27, 2026 09:00 UTC
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New registry aims to improve corneal transplants with AI
Knowledge-focused CompletedThis study created a nationwide registry to track long-term results of corneal surgeries and diseases. Researchers collected images and data from 19 participants to help understand what makes corneal transplants successful. The goal is to use this information to develop AI that c…
Sponsor: Nitin Vaswani • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:06 UTC
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AI eye chatbot matches doctors in taking patient history
Knowledge-focused CompletedThis study tested whether a large language model (like ChatGPT) could collect medical history and suggest eye tests as well as doctors do. 172 patients with non-emergency eye problems took part. The AI's performance was compared to standard care, with senior specialists checking …
Phase: NA • Sponsor: Zhongshan Ophthalmic Center, Sun Yat-sen University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:10 UTC