Corneal dystrophy

This clinical trial is testing whether an investigational eye drop called STN1010904 can improve vision in people with Fuchs endothelial corneal dystrophy (FECD), a condition that damages the cornea's inner layer and can lead to blurry vision. The study will compare two different…

This phase II trial tests the drug rituximab (Rituxan) as a first treatment for multicentric Castleman disease, a rare immune disorder, in 15 adults in Malawi. Some high-risk patients also receive etoposide. The study aims to see if rituximab is safe and works better than standar…

This study tested whether ripasudil eye drops can help people with Fuchs endothelial corneal dystrophy recover vision faster after a specific cornea procedure called descemetorhexis. The trial involved 107 adults and compared the drops to a placebo over 12 weeks of treatment, fol…

This study tested whether ripasudil eye drops can help people with Fuchs endothelial corneal dystrophy recover vision faster after combined cataract and cornea surgery. 110 adults received either the eye drops or a placebo for 12 weeks, followed by a taper and 38-week follow-up. …

This study is testing a new eye imaging device called the VG200D, which uses advanced technology to take detailed pictures of the eye. Researchers want to see if it works as well as a standard device for measuring parts of the eye in people with glaucoma, retina problems, corneal…

This study tests a microscope that has an OCT scanner built directly into it, allowing surgeons to take detailed cross-sectional images of the eye during surgery. The goal is to see if this setup is practical and whether the extra visual information helps guide surgical decisions…

This study looks at immune cell patterns in people with three types of nephrotic syndrome—membranous nephropathy, minimal change disease, and focal segmental glomerulosclerosis. Researchers aim to see if certain immune cells can serve as biomarkers to track how well a patient res…

This study compared two types of cornea transplant surgery (DSAEK and DMEK) for people with Fuchs' endothelial dystrophy, a condition that clouds the cornea. Researchers measured vision and tracked side effects like swelling and eye pressure in 112 participants. The goal was to f…

This completed study looked at whether diabetes in a cornea donor affects the success of a corneal transplant called DMEK. Over 1,000 participants received a cornea from either a donor with or without diabetes. Researchers tracked graft failure and cell loss for one year to see i…

This study created a nationwide registry to track long-term results of corneal surgeries and diseases. Researchers collected images and data from 19 participants to help understand what makes corneal transplants successful. The goal is to use this information to develop AI that c…

This study tested whether a large language model (like ChatGPT) could collect medical history and suggest eye tests as well as doctors do. 172 patients with non-emergency eye problems took part. The AI's performance was compared to standard care, with senior specialists checking …