Corneal dystrophy

This trial tests a single injection of GEB-101, a gene-editing treatment, directly into the cornea of people with TGFBI-related corneal dystrophy, a hereditary condition that causes progressive vision loss. The study aims to see if the treatment is safe and whether it can slow or…

This phase 2 trial tests whether a single injection of EO2002, made from magnetic human corneal endothelial cells, can safely improve vision in people with corneal edema caused by endothelial dysfunction. Participants receive either a low or high dose of cells or a placebo inject…

This phase 3 trial is testing whether giving men with metastatic prostate cancer half the standard dose of certain hormone therapies (called ARPIs) can be just as effective as the full dose, while causing less fatigue and fewer treatment stoppages. About 1,500 men with prostate c…

This trial compares two surgical techniques for treating corneal basement membrane dystrophy, a condition that causes blurred vision and painful eye erosions. One method is manual scraping of the damaged corneal layer; the other uses a laser to remove it. The study aims to find w…

This study will test a special gel that can be injected into the eye to seal wounds on the cornea (the clear front part of the eye) without needing stitches. The gel turns from liquid to solid inside the eye and helps the cornea heal naturally. About 30 adults with certain types …

This study tests a combination of darolutamide, hormone therapy, and a lower dose of the chemotherapy drug docetaxel in men with metastatic hormone-sensitive prostate cancer. The goal is to see if this approach can keep PSA levels very low (below 0.2 ng/mL) at 24 weeks while redu…

This early-phase trial tests whether adding a dietary supplement called LC-K76 to standard hormone therapy is safe for men with metastatic hormone-sensitive prostate cancer. Forty men will receive the supplement plus hormone therapy for 24 weeks, then be followed for another 24 w…

This study checks if a special thinking test (MoCA Blind) can find memory or thinking problems after cornea surgery. It includes 200 adults with cornea disease who will take the test before and 90 days after surgery. The goal is to give doctors a better way to spot these issues i…

This study will test a new type of artificial lens, called the PureSee IOL, in 10 people who need surgery for both cataracts and a cornea condition called Fuchs dystrophy. The goal is to see if this lens helps patients see well at different distances and reduces their need for gl…

This observational study compares corneal thickness six weeks after routine cataract surgery in people with Fuchs endothelial corneal dystrophy (FECD) versus those without the condition. Researchers aim to see whether FECD eyes swell more or recover differently after surgery. Par…

This study looks at whether a test called minimal residual disease (MRD) can help predict how well treatment works in men with metastatic hormone-sensitive prostate cancer. Researchers will track 50 newly diagnosed patients to see how different gene patterns affect treatment resp…