Corneal disorder
MONDO:0000942A non-neoplastic or neoplastic disorder that affects the cornea. Representative examples include keratitis, bullous keratopathy, and squamous cell carcinoma.
Also known as: cornea disease, cornea disease or disorder, corneal disease, corneal disorder, disease of cornea, disease or disorder of cornea, disorder of cornea
465 clinical trials for this condition and its sub-types, 46 tagged with Corneal disorder itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
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Sub-types of Corneal disorder
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Keratitis 6 trials · 298 incl. sub-types
11 sub-types
- Keratoconjunctivitis 1 trial · 260 incl. sub-types Sub-types →
- Corneal infection 6 trials · 22 incl. sub-types Sub-types →
- Corneal ulcer 16 trials · 18 incl. sub-types Sub-types →
- Corneal neovascularization 5 trials Sub-types →
- Deep keratitis 0 trials · 1 incl. sub-types Sub-types →
- Autosomal dominant keratitis 0 trials
- Filamentary keratitis 0 trials
- Macular keratitis 0 trials
- Photokeratitis 0 trials
- Scleroperikeratitis 0 trials
- Superficial keratitis 0 trials Sub-types →
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Keratoconus 61 trials
11 sub-types
- Keratoconus, stable condition 2 trials
- Acute hydrops keratoconus 0 trials
- Keratoconus 1 0 trials
- Keratoconus 2 0 trials
- Keratoconus 3 0 trials
- Keratoconus 4 0 trials
- Keratoconus 5 0 trials
- Keratoconus 6 0 trials
- Keratoconus 7 0 trials
- Keratoconus 8 0 trials
- Keratoconus 9 0 trials
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Corneal dystrophy 6 trials · 60 incl. sub-types
13 sub-types
- Corneal endothelial dystrophy 5 trials · 36 incl. sub-types Sub-types →
- Posterior corneal dystrophy 0 trials · 34 incl. sub-types Sub-types →
- Stromal corneal dystrophy 2 trials · 16 incl. sub-types Sub-types →
- Superficial corneal dystrophy 0 trials · 7 incl. sub-types Sub-types →
- Epithelial-stromal TGFBI dystrophy 1 trial · 3 incl. sub-types Sub-types →
- Chandler syndrome 2 trials
- Epithelial and subepithelial corneal dystrophy 0 trials · 2 incl. sub-types Sub-types →
- Finnish type amyloidosis 0 trials
- Judge Misch wright syndrome 0 trials
- Autosomal dominant keratitis 0 trials
- Band keratopathy 0 trials
- Corneal dystrophy, punctiform and polychromatic pre-descemet 0 trials
- Macular dystrophy, fenestrated sheen type 0 trials
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Corneal edema 17 trials · 24 incl. sub-types
4 sub-types
- Bullous keratopathy 12 trials
- Secondary corneal edema 6 trials
- Contact lens corneal edema 0 trials
- Idiopathic corneal edema 0 trials
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Cornea neoplasm 0 trials · 17 incl. sub-types
3 sub-types
- Benign neoplasm of cornea 0 trials · 17 incl. sub-types Sub-types →
- Cornea cancer 0 trials Sub-types →
- Corneal intraepithelial neoplasm 0 trials
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Keratopathy 3 trials · 15 incl. sub-types
2 sub-types
- Bullous keratopathy 12 trials
- Band keratopathy 0 trials
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Corneal ectasia 11 trials
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Limbal stem cell deficiency 10 trials
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Pellucid marginal degeneration 4 trials
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Corneal degeneration 1 trial · 2 incl. sub-types
5 sub-types
- Arcus senilis 1 trial
- Band keratopathy 0 trials
- Nodular degeneration of cornea 0 trials
- Peripheral degeneration of cornea 0 trials
- Phthisical cornea 0 trials
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Cornea plana 0 trials · 2 incl. sub-types
2 sub-types
- Cornea plana 1, autosomal dominant 2 trials
- Cornea plana 2 0 trials
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Peters anomaly 1 trial
2 sub-types
- Peters anomaly-cataract syndrome 0 trials
- Von Hippel anomaly 0 trials
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Pseudopterygium 1 trial
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Arnold stickler bourne syndrome 0 trials
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Bowman's membrane folds or rupture 0 trials
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Terrien marginal degeneration 0 trials
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X-linked corneal dermoid 0 trials
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Brittle cornea syndrome 0 trials
2 sub-types
- Brittle cornea syndrome 1 0 trials
- Brittle cornea syndrome 2 0 trials
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Corneal argyrosis 0 trials
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Corneal deposit 0 trials
3 sub-types
- Anterior corneal pigmentation 0 trials
- Posterior corneal pigmentation 0 trials
- Stromal corneal pigmentation 0 trials
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Corneal staphyloma 0 trials
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Megalocornea 0 trials
1 sub-type
- Isolated congenital megalocornea 0 trials
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Sclerocornea 0 trials
2 sub-types
- Anterior segment dysgenesis 7 0 trials
- Sclerocornea, autosomal dominant 0 trials
Most studied deeper sub-types
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Can a single Gene-Editing injection stop a blinding corneal disease?
Cure Not yet recruitingThis trial tests a single injection of GEB-101, a gene-editing treatment, directly into the cornea of people with TGFBI-related corneal dystrophy, a hereditary condition that causes progressive vision loss. The study aims to see if the treatment is safe and whether it can slow or…
Phase 1/2 • Sponsor: GenEditBio Limited • Aim: Cure
Last updated Sep 12, 2026 00:00 UTC
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Can immune cells heal a rare eye ulcer?
Disease control Not yet recruitingThis trial tests whether injecting natural killer (NK) cells into the eye can help people with refractory Mooren's ulcer, a painful and recurring corneal condition. Six participants will receive the cell injection and be followed for 48 weeks to see if it improves corneal thickne…
Sponsor: Suxia Li • Aim: Disease control
Last updated Aug 26, 2026 00:00 UTC
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No-Stitch eye glue could spare patients pain and scarring
Disease control Not yet recruitingThis study tests a special hydrogel that acts like a glue to hold eye tissues together during surgery, avoiding the need for stitches. Stitches can cause pain, swelling, and scarring, but this gel uses light to bond quickly and gently. The trial will include 20 people with cornea…
Sponsor: Suxia Li • Aim: Disease control
Last updated Jun 27, 2026 12:37 UTC
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New eye test spots brain fog after cornea surgery
Diagnosis Not yet recruitingThis study checks if a special thinking test (MoCA Blind) can find memory or thinking problems after cornea surgery. It includes 200 adults with cornea disease who will take the test before and 90 days after surgery. The goal is to give doctors a better way to spot these issues i…
Sponsor: The S.N. Fyodorov Eye Microsurgery State Institution • Aim: Diagnosis
Last updated Sep 21, 2026 23:00 UTC
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Eye surface disease study seeks to unlock vision predictors
Knowledge-focused Not yet recruitingThis study aims to find which eye tests best predict vision in people with surface eye diseases like neurotrophic keratopathy and limbal stem cell deficiency. Researchers will collect data from standard exams and patient questionnaires from 1,000 adults. The goal is to identify k…
Sponsor: IRCCS San Raffaele • Aim: Knowledge-focused
Last updated Jul 16, 2026 00:00 UTC
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Eye study aims to map corneal thickness in common vision problems
Knowledge-focused Not yet recruitingThis study will use a special imaging device (AS-OCT) to measure the thickness of the cornea's outer layer in 360 adults with nearsightedness, farsightedness, astigmatism, or normal vision. The goal is to see if different vision problems have unique thickness patterns. Participan…
Sponsor: Sohag University • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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New eye scanner could sharpen vision for transplant patients
Knowledge-focused Not yet recruitingThis study will test a new type of eye imaging called OCT in 24 adults who have had a cornea transplant. The goal is to see if the new method can take clearer pictures of the eye to help doctors better detect eye diseases. Participants will have their eyes scanned with the new de…
Sponsor: Vanderbilt University Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:01 UTC
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Discarded eye tissue yields clues for better vision correction
Knowledge-focused Not yet recruitingThis study will analyze corneal tissue that is normally thrown away during a common myopia surgery called CLEAR (or SMILE). Researchers will test the tissue's strength and structure to learn more about how the cornea behaves. The goal is to improve future eye surgeries by underst…
Sponsor: University of Bern • Aim: Knowledge-focused
Last updated Jun 26, 2026 19:09 UTC