Congenital limb malformation

This early-phase study tests a new drug called E7090, alone or with other cancer medicines, in people with a common type of advanced breast cancer (ER+, HER2-). The main goal is to find safe doses and understand side effects. About 51 participants will take part to guide future r…

This trial compares two surgical tools—a standard surgical blade and a special ophthalmic knife—for cutting the Achilles tendon in children aged 2 to 5 with clubfoot. The goal is to see which tool improves ankle movement more and causes fewer problems like bleeding or infection. …

This study tested a new, less invasive surgery for children aged 4 to 10 with a stubborn clubfoot deformity called 'bean-shaped foot.' Instead of cutting bones, surgeons placed a small metal plate across a joint in the foot to gently guide growth and straighten the foot over time…

This phase 2 trial tested sodium valproate, a drug used for seizures, in 41 children with Rubinstein-Taybi syndrome (RTS), a rare genetic condition causing intellectual disability. Participants aged 6 to 21 received either the drug or a placebo for one year. Researchers measured …

This study looked at 32 children with clubfoot who were already treated with the Ponseti method. Researchers wanted to see if adding myofascial release and static stretching to nighttime bracing could prevent the foot from relapsing. The children received therapy sessions and wer…

This study tested an experimental drug called E7090 in 63 people with advanced bile duct cancer that has a specific genetic change (FGFR2 fusion). Participants had already tried chemotherapy without success. The goal was to see if the drug could shrink tumors. Results help determ…

This study tested whether a custom dynamic hand splint helps improve hand movement after surgery to repair torn extensor tendons. Forty adults aged 20-40 with tendon injuries in zones 5 or 6 participated. After three weeks of wearing a static splint, one group used the dynamic sp…

This study tested whether a new prosthetic hand, the SoftHand Pro, helps people with below-elbow limb loss perform daily activities better than a commonly used hand, the i-Limb. Thirty-six adults who already use a myoelectric hand took part over 8 weeks. Researchers measured how …

This study tested two numbing methods for a common clubfoot procedure in infants: a needle-free jet injection that works in 1-2 minutes versus a topical cream that takes 30 minutes. Researchers measured pain using a standard scale, heart rate, and oxygen levels in 107 babies. The…

This study follows nearly 600 people with Smith-Magenis syndrome (SMS), a rare genetic condition, to track how their health, behavior, and development change over time. Researchers will perform detailed medical exams, genetic tests, and surveys to better understand the syndrome's…

This study tests whether a teaching approach called ARCS (Attention, Relevance, Confidence, Satisfaction) can improve nursing students' ability to perform cardiovascular physical exams. One hundred second-year nursing students will receive either standard training or standard tra…

This study tested a new prosthetic foot for children with leg amputations or birth defects. Thirteen kids walked with the device and gave feedback on stiffness and performance. The goal was to gather ideas to improve future foot designs.

This study investigates whether changes in DNA methylation—a kind of chemical switch—might cause certain rare limb malformations that appear without a family history. Researchers will compare DNA samples from 40 people with Amelia (missing two or four limbs) or Femur Fibula Ulna …

This completed study looked at 151 children with common postural conditions like flat feet, knock knees, or scoliosis. Researchers used wearable motion sensors and clinical tests to measure balance and motor control, then compared the results to healthy children. The goal was to …

This completed study involved 55 children with clubfoot who could walk. Researchers showed videos of the children's feet to experienced surgeons and asked for treatment recommendations. The goal was to see if a video-based scoring system (PBS-score) matches what surgeons would re…

This study looked at whether doctors can reliably score clubfoot severity from video recordings instead of in-person exams. 55 children with clubfoot were assessed by multiple raters using a standard scoring tool. The goal was to see if video assessments could be a trustworthy op…