Cluster headache syndrome
MONDO:0043537A headache disorder that is characterized by periodic severe, unilateral orbital, supraorbital, and/or temporal pain, and is associated with ipsilateral cranial autonomic symptoms.
Also known as: Cephalgia, histamine, Cephalgias, histamine, Horton headache, Horton syndrome, Horton's headache, Horton's neuralgia, Horton's syndrome, Hortons syndrome
29 clinical trials for this condition and its sub-types.
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Broader categories
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Can yoga ease severe headaches? small pilot study aims to find out
Symptom relief OngoingThis pilot study is testing whether yoga-based movements, done online or in person, can help people with chronic migraine or cluster headache. Twenty adults aged 18-65 will participate. The goal is to see if yoga improves headache frequency, sleep quality, and overall well-being …
Phase: NA • Sponsor: Karolinska Institutet • Aim: Symptom relief
Last updated Jul 31, 2026 00:00 UTC
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Nerve zapper offers hope for chronic headache sufferers
Symptom relief ENROLLING_BY_INVITATIONThis study looks at whether a 60-day nerve stimulation device placed near the back of the head can help people with stubborn headaches. Researchers will track pain levels, daily function, and how often participants need emergency care. About 300 adults with various headache types…
Sponsor: Yale University • Aim: Symptom relief
Last updated Jun 27, 2026 14:00 UTC
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Electric zaps to the head may ease cluster headaches
Symptom relief OngoingThis early study tests the safety of a new device called PRIMUS that uses mild electrical pulses on nerves in the forehead and back of the head to treat chronic cluster headache. Five people with frequent, hard-to-treat attacks will be enrolled. The goal is to see if the device i…
Phase: NA • Sponsor: Salvia BioElectronics • Aim: Symptom relief
Last updated Jun 27, 2026 12:23 UTC
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Scientists use chili peppers and ice water to unlock headache secrets
Knowledge-focused ENROLLING_BY_INVITATIONThis study looks at how headaches work by using capsaicin (the spicy part of chili peppers) and ice water to trigger mild, temporary pain in people with and without headache disorders. Researchers measure changes in pain signals and tear production to better understand conditions…
Phase: PHASE1 • Sponsor: The University of Texas Health Science Center, Houston • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:05 UTC
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Heart risk under the microscope: verapamil for cluster headaches
Knowledge-focused OngoingThis study looks at how often a common heart side effect (first-degree atrioventricular block) occurs when verapamil is used at high doses to prevent cluster headaches. Researchers will monitor 60 patients starting or already on verapamil, using ECGs and blood tests. The goal is …
Phase: PHASE4 • Sponsor: Centre Hospitalier Universitaire de Nice • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:01 UTC