Central nervous system vasculitis

This trial investigates whether bosentan, a drug that blocks endothelin and relaxes blood vessels, can help people who suddenly lose vision from giant cell arteritis (Horton's disease). Standard steroid treatment often fails to restore sight once blindness occurs. The study enrol…

This phase 3 trial tested secukinumab, a biologic drug, in 354 people with giant cell arteritis (GCA), a condition causing inflamed arteries. Participants received either secukinumab or a placebo, along with a steroid taper. The goal was to see if secukinumab could help more peop…

This study looked at how an intravenous (IV) form of secukinumab is processed by the body and whether it is safe for adults with giant cell arteritis (GCA) or polymyalgia rheumatica (PMR). These conditions cause inflammation in blood vessels or muscles, leading to pain and stiffn…

This study tested the drug secukinumab (Cosentyx) in 151 adults with newly diagnosed giant cell arteritis, a condition causing inflamed blood vessels. Participants were in remission and received either secukinumab or a placebo, along with a steroid taper. The goal was to see if s…

This study tested the drug upadacitinib (RINVOQ) in 429 people with giant cell arteritis, a condition causing inflamed blood vessels. Participants took the drug or a placebo along with steroids. The goal was to see if upadacitinib helps achieve remission faster and with less ster…

This study tested whether chewing gum can help doctors diagnose giant cell arteritis (Horton's disease), a condition where blood vessels become inflamed. The idea is that chewing may trigger jaw pain in people with the disease, making it easier to spot. Researchers compared resul…

This study looked at whether a PET/CT scan of the head arteries can accurately diagnose giant cell arteritis, a type of blood vessel inflammation. Researchers compared the scan results to those from ultrasound and MRI in 70 patients suspected of having the condition. The goal was…

Giant cell arteritis (GCA) causes inflamed arteries and can lead to blindness if not treated quickly. This study tested a new digital PET/CT scan that can see tiny arteries in the head, which older scans missed. 92 patients with suspected GCA got both a PET/CT and an ultrasound. …

This study tested whether a low dose (4.5 mg) of naltrexone, a drug already used for alcoholism, can improve physical health and quality of life in people with vasculitis. Sixty participants took either the drug or a placebo daily for six weeks. The goal was to see if the drug le…

This observational study followed 198 adults aged 50–85 with giant cell arteritis or polymyalgia rheumatica to understand how common treatments (glucocorticoids and interleukin-6 inhibitors) affect diabetes risk. Researchers tracked blood sugar levels and other markers over time.…

This study looked at whether a type of immune cell called T CD8 plays a role in Horton's disease, a condition that causes inflammation in blood vessels. Researchers took extra blood samples and performed standard tests on 30 newly diagnosed patients to measure these immune cells.…

This study looked at over 1,600 people with giant cell arteritis, a condition that inflames blood vessels and raises heart risks. Researchers compared tocilizumab and methotrexate to see which better prevents heart attacks, strokes, or death. Using French health data, they analyz…

This study looked at blood samples from 41 people with giant cell arteritis (Horton's disease), a condition that causes inflammation in blood vessels. Researchers examined specific immune cells called regulatory T cells to see if they are defective in this disease. The goal is to…

This study looked at how the COVID-19 lockdown changed the health habits and medical care of 1,343 people with chronic conditions like heart disease, multiple sclerosis, and hemophilia. Researchers used phone surveys to track medication use, lifestyle changes, and access to healt…