Bronchiectasis

This study tests a daily tablet called BI 1291583 (Verducatib) in 268 adults with bronchiectasis, a long-term lung condition. Participants who were in earlier trials continue or switch to the drug for up to one year. The main goal is to check safety and see if the drug reduces lu…

This early-stage trial tests a new inhaled nitric oxide treatment (RESP30X) in 60 adults with non-cystic fibrosis bronchiectasis who have stubborn lung infections like Pseudomonas. The main goals are to check safety and how well the body tolerates the mist, while also seeing if i…

This study provides early access to brensocatib, an experimental tablet, for people with non-cystic fibrosis bronchiectasis who finished the ASPEN trial. Participants must have already taken brensocatib without serious side effects. The goal is to offer continued treatment while …

This study tests a new device called SonoHeal that uses sound waves to help people with cystic fibrosis, bronchiectasis, or COPD clear mucus from their lungs. Fifteen participants will try the device at home to see if it is easy to use and acceptable. The study also compares it t…

This pilot study tests whether home-based or video-supervised exercise programs are acceptable and helpful for people with chronic lung diseases like IPF, sarcoidosis, bronchiectasis, asthma, and other interstitial lung diseases. Fifty participants will be randomly assigned to on…

This study tests whether using a breathing muscle training device, along with standard physical therapy, helps people recover more quickly after a lung transplant. About 90 adults waiting for a lung transplant will take part. The goal is to see if this training improves breathing…

This study looks at how changing the pressure inside a breathing machine affects lung function in 20 patients with obstructive airway diseases who are on full ventilator support. Researchers will test different pressure levels to see how they impact gas exchange and how the lungs…

This study is testing whether a breathing test called the lung clearance index (LCI) can detect small airways disease in adults with chronic lung conditions like asthma or fibrosis. Researchers will compare results from 300 patients with lung disease to 300 healthy volunteers. Th…

This study follows 200 adults in Taiwan who have bronchiectasis, a lung condition that causes widening of the airways and leads to repeated infections. Researchers will track their health problems, treatments, and how the disease changes over time. The goal is to learn more about…

This study aims to see if a simple, non-invasive breathing test can accurately measure the acidity (pH) in the airways, which is often abnormal in lung diseases. Researchers will compare results from this breath test with standard methods in 150 healthy volunteers and people with…

This study looks at sleep quality in 60 adults with non-cystic fibrosis bronchiectasis, a chronic lung condition. Researchers will measure how well participants sleep and see if poor sleep is linked to more severe lung disease, worse breathing tests, or more lung damage on CT sca…

This study watches 200 people with lung, gut, or hormone diseases over time using special brain scans (PET). It aims to see how these diseases change brain activity and whether those changes can predict tumor return, spread, or survival. No new treatment is tested—just observatio…