Blood coagulation disease
MONDO:0001531A condition in which there is a deviation from or interruption of the normal coagulation properties of the blood.
Also known as: blood coagulation disorder, coagulation defect, coagulation disorder, coagulation disorder, blood, coagulation disorders, blood, coagulopathy, disorder, blood coagulation, disorders, blood coagulation
541 clinical trials for this condition and its sub-types, 54 tagged with Blood coagulation disease itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Part of
Sub-types of Blood coagulation disease
-
Inherited blood coagulation disorder 8 trials · 323 incl. sub-types
39 sub-types
- Hemophilia A 180 trials Sub-types →
- Hemophilia B 84 trials · 91 incl. sub-types Sub-types →
- Hereditary von Willebrand disease 18 trials · 29 incl. sub-types Sub-types →
- Inherited thrombophilia 0 trials · 28 incl. sub-types Sub-types →
- Hereditary hemolytic uremic syndrome 0 trials · 19 incl. sub-types Sub-types →
- Wiskott-Aldrich syndrome 10 trials
- Glanzmann thrombasthenia 8 trials Sub-types →
- Platelet-type bleeding disorder 10 8 trials
- Congenital thrombotic thrombocytopenic purpura 5 trials
- Hereditary thrombocytopenia and hematologic cancer predisposition syndrome 1 trial · 5 incl. sub-types Sub-types →
- Hermansky-Pudlak syndrome 4 trials Sub-types →
- Congenital vitamin K-dependent coagulation factors deficiency 0 trials · 4 incl. sub-types Sub-types →
- Congenital factor XII deficiency 1 trial
- Congenital plasminogen activator inhibitor type 1 deficiency 1 trial
- Hypoplasminogenemia 1 trial
- Ehlers-Danlos syndrome, fibronectinemic type 0 trials
- Scott syndrome 0 trials
- Tatsumi factor deficiency 0 trials
- Alpha-2-plasmin inhibitor deficiency 0 trials
- Congenital factor V deficiency 0 trials
- Congenital factor XI deficiency 0 trials
- Congenital high-molecular-weight kininogen deficiency 0 trials
- Cytosolic phospholipase-A2 alpha deficiency associated bleeding disorder 0 trials
- Dysplasminogenemia 0 trials
- Factor 5 and Factor VIII, combined deficiency of, 2 0 trials
- Factor V and factor VIII, combined deficiency of, type 1 0 trials
- Factor VII and Factor VIII, combined deficiency of 0 trials
- Factor XIII, A subunit, deficiency of 0 trials
- Factor XIII, b subunit, deficiency of 0 trials
- Familial thrombomodulin anomalies 0 trials
- Hereditary thrombocytosis with transverse limb defect 0 trials
- Hypercoagulability syndrome due to glycosylphosphatidylinositol deficiency 0 trials
- Inherited prekallikrein deficiency 0 trials
- Plasminogen deficiency, type II 0 trials
- Platelet-type bleeding disorder 12 0 trials
- Platelet-type bleeding disorder 14 0 trials
- Platelet-type bleeding disorder 16 0 trials
- Platelet-type bleeding disorder 18 0 trials
- Platelet-type bleeding disorder 8 0 trials
-
Coagulation protein disease 13 trials · 274 incl. sub-types
28 sub-types
- Hemophilia 55 trials · 216 incl. sub-types Sub-types →
- Von Willebrand disease (hereditary or acquired) 39 trials · 46 incl. sub-types Sub-types →
- Acquired coagulation factor deficiency 4 trials · 16 incl. sub-types Sub-types →
- Congenital fibrinogen deficiency 2 trials · 6 incl. sub-types Sub-types →
- Factor VII deficiency 6 trials Sub-types →
- Thrombophilia due to activated protein C resistance 5 trials
- Congenital vitamin K-dependent coagulation factors deficiency 0 trials · 4 incl. sub-types Sub-types →
- Factor X deficiency 2 trials Sub-types →
- Congenital factor XII deficiency 1 trial
- Congenital plasminogen activator inhibitor type 1 deficiency 1 trial
- Hypoplasminogenemia 1 trial
- East Texas bleeding disorder 0 trials
- Tatsumi factor deficiency 0 trials
- Alpha-2-plasmin inhibitor deficiency 0 trials
- Combined deficiency of factor V and factor VIII 0 trials Sub-types →
- Combined deficiency of factor VII and factor X 0 trials
- Congenital high-molecular-weight kininogen deficiency 0 trials
- Dysplasminogenemia 0 trials
- Factor V amsterdam bleeding disorder 0 trials
- Factor V atlanta bleeding disorder 0 trials
- Factor V deficiency 0 trials Sub-types →
- Factor V short isoforms-related bleeding disorder 0 trials
- Factor XIII deficiency 0 trials Sub-types →
- Hemorrhagic disease due to alpha-1-antitrypsin Pittsburgh mutation 0 trials
- Inherited prekallikrein deficiency 0 trials
- Multiple sclerosis-ichthyosis-factor VIII deficiency syndrome 0 trials
- Plasminogen deficiency, type II 0 trials
- Thrombomodulin-related bleeding disorder 0 trials
-
Thrombotic microangiopathy 26 trials · 151 incl. sub-types
2 sub-types
- Thrombocytopenic purpura 8 trials · 116 incl. sub-types Sub-types →
- Atypical hemolytic-uremic syndrome 19 trials Sub-types →
-
Thrombophilia 12 trials · 75 incl. sub-types
4 sub-types
- Inherited thrombophilia 0 trials · 28 incl. sub-types Sub-types →
- Thrombotic thrombocytopenic purpura 15 trials · 20 incl. sub-types Sub-types →
- Disseminated intravascular coagulation 15 trials Sub-types →
- Protein S deficiency 3 trials Sub-types →
-
Hemolytic-uremic syndrome 7 trials · 24 incl. sub-types
2 sub-types
- Hereditary hemolytic uremic syndrome 0 trials · 19 incl. sub-types Sub-types →
- Infection-related hemolytic uremic syndrome 0 trials · 2 incl. sub-types Sub-types →
-
Hemorrhagic disease of newborn 1 trial
-
Marantic endocarditis 0 trials
-
Prekallikrein deficiency 0 trials
1 sub-type
- Inherited prekallikrein deficiency 0 trials
Most studied deeper sub-types
-
New IVIg therapy aims to boost platelets in chronic ITP patients
Disease control Recruiting nowThis study tests a medicine called KIg 10 (intravenous immunoglobulin) in adults with chronic ITP, a condition where the immune system destroys platelets, causing bleeding and bruising. The goal is to see if KIg 10 can safely raise platelet counts and stop bleeding. About 40 peop…
Phase 3 • Sponsor: Kedrion S.p.A. • Aim: Disease control
Last updated Sep 13, 2026 00:00 UTC
-
New drug aims to stop bleeding in emergency surgeries for blood thinner users
Disease control Recruiting nowThis Phase 3 trial tests whether a single dose of VMX-C001 can control bleeding better than usual care in 800 patients on blood thinners who need urgent high-risk surgery. Participants receive either VMX-C001 or standard treatment before their procedure, and experts will rate ble…
Phase 3 • Sponsor: VarmX B.V. • Aim: Disease control
Last updated Aug 23, 2026 00:00 UTC
-
New drug aims to stop deadly clots in sepsis patients
Disease control Recruiting nowThis early study tests a new drug called BAY 3389934 in 36 hospital ICU patients with sepsis-induced coagulopathy, a condition where the body forms dangerous blood clots. The main goal is to check safety and find the right dose. Researchers will monitor side effects and blood clo…
Phase 1 • Sponsor: Bayer • Aim: Disease control
Last updated Aug 22, 2026 00:00 UTC
-
New study tracks Real-World impact of hemophilia drug on joint health
Disease control Recruiting nowThis study follows 250 people with hemophilia A who are taking efanesoctocog alfa to prevent bleeding. Researchers want to see how well it protects joints from bleeds over time in everyday life. Participants will be observed for several years to track bleeding rates and treatment…
Phase 4 • Sponsor: Swedish Orphan Biovitrum • Aim: Disease control
Last updated Jul 02, 2026 00:00 UTC
-
New clotting factor offers continued bleeding control for hemophilia a patients
Disease control Recruiting nowThis study gives people with moderate or severe hemophilia A who finished a previous trial continued access to the drug efanesoctocog alfa. The drug is a lab-made clotting factor that helps prevent bleeding episodes. Researchers will monitor safety and how well it controls bleedi…
Phase 3 • Sponsor: Swedish Orphan Biovitrum • Aim: Disease control
Last updated Jun 28, 2026 00:00 UTC
-
New reversal agent TAK-330 aims to stop bleeding in emergency surgeries
Disease control Recruiting nowThis Phase 3 trial tests TAK-330, a drug designed to reverse the effects of common blood thinners (Factor Xa inhibitors) in patients who need urgent surgery. About 440 adults will be randomly assigned to receive TAK-330 or standard care before their procedure. The main goal is to…
Phase 3 • Sponsor: Takeda • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
-
New trial aims to stop deadly bleeding after birth
Disease control Recruiting nowThis study tests whether giving a clotting protein called factor XIII early can reduce blood loss in women with heavy bleeding after childbirth. About 988 women having a vaginal delivery will be randomly assigned to receive either factor XIII plus standard care or standard care a…
Phase 4 • Sponsor: Christian Haslinger • Aim: Disease control
Last updated Jun 27, 2026 12:25 UTC
-
New clotting drug may cut bleeding risk in rare cancer surgery
Disease control Recruiting nowThis study tests whether a concentrated clotting drug (fibrinogen) can better control major blood loss during surgery for pseudomyxoma peritonei, a rare abdominal cancer. About 90 adults will be randomly assigned to receive either the drug or a standard blood product during their…
Phase 3 • Sponsor: CSL Behring • Aim: Disease control
Last updated Jun 27, 2026 11:01 UTC
-
Heart surgery bleeding study tests best drug dose
Disease control Recruiting nowThis study compares three different doses of the drug tranexamic acid in 150 adults having elective heart surgery with a heart-lung machine. The goal is to find which dose best controls bleeding and reduces the need for blood transfusions. Researchers will measure how long the dr…
Sponsor: University of Ioannina • Aim: Disease control
Last updated Jun 26, 2026 15:39 UTC
-
Pocket-Sized clot check could make blood thinner safer
Diagnosis Recruiting nowThis study tests a small, battery-powered device called ClotChek™ that measures how fast a patient's blood clots using a fresh drop of blood. Researchers want to see if it can tell the difference between people on common blood thinners (rivaroxaban or apixaban) and those not on a…
Sponsor: Perosphere Technologies Inc. • Aim: Diagnosis
Last updated Jun 26, 2026 17:56 UTC
-
New model aims to decode mysterious blood test results
Knowledge-focused Recruiting nowThis study is checking if a computer model can accurately predict why some people have a prolonged blood clotting time (APTT). The model uses data from routine blood tests to tell if the cause is harmless or a sign of a clotting disorder. Researchers will test it on 1,500 patient…
Sponsor: Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz • Aim: Knowledge-focused
Last updated Sep 13, 2026 00:00 UTC
-
Massive study aims to crack the code on Kids' medications
Knowledge-focused Recruiting nowThis study is collecting blood and other samples from 5,000 children and young adults (under 21) who are already taking certain medications as part of their regular care. The goal is to understand how these drugs move through and affect children's bodies, so doctors can prescribe…
Sponsor: Duke University • Aim: Knowledge-focused
Last updated Aug 23, 2026 00:00 UTC
-
Massive study to track Real-World safety of new blood disorder drugs
Knowledge-focused Recruiting nowThis study is collecting long-term safety and effectiveness data on treatments for various blood disorders, including hemophilia, sickle cell disease, and clotting disorders. It aims to enroll 3000 people of any age with these conditions. Researchers will monitor side effects, co…
Sponsor: American Thrombosis and Hemostasis Network • Aim: Knowledge-focused
Last updated Aug 19, 2026 00:00 UTC
-
New study aims to set normal clotting values for kids using a rapid test
Knowledge-focused Recruiting nowThis study looks at how well a rapid blood test called TEG 6s measures clotting in healthy children. About 125 kids having planned surgery will give a small blood sample for the test. The goal is to find normal values for children and compare them to existing ranges. No treatment…
Sponsor: Indiana University • Aim: Knowledge-focused
Last updated Aug 06, 2026 00:00 UTC
-
Massive gene hunt aims to unlock secrets of blood disorders
Knowledge-focused Recruiting nowThis study collects blood, bone marrow, and other samples along with health information from up to 1,716 people with non-cancerous blood diseases and their family members. Researchers will analyze the participants' genes to find new genetic causes of these conditions and understa…
Sponsor: St. Jude Children's Research Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:04 UTC
-
Your genes, your meds: 1200-Patient study tests smarter prescribing
Knowledge-focused Recruiting nowThis study collects DNA from 1200 patients receiving routine care at the University of Chicago. Researchers look for genetic differences that might affect how well a drug works or how likely it is to cause side effects. The goal is to see if giving this genetic information to doc…
Sponsor: University of Chicago • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:11 UTC
-
Can a 5-Minute blood test save trauma patients from unnecessary treatment?
Knowledge-focused Recruiting nowThis study looks at whether a quick bedside test can measure fibrinogen levels in trauma patients with severe bleeding within minutes, instead of the usual 30-45 minutes. Fibrinogen helps blood clot, and low levels can worsen bleeding. The test is being checked for feasibility an…
Sponsor: Erasmus Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:03 UTC
-
Painkiller-blood thinner combo under scrutiny in cancer patients
Knowledge-focused Recruiting nowThis study looks at how metamizole (Optalgin), a common painkiller, changes the levels of blood thinners (apixaban or rivaroxaban) in cancer patients. Researchers will measure drug concentrations at several time points in 30 adults. The goal is to understand if metamizole interfe…
Sponsor: Rambam Health Care Campus • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:01 UTC
-
Heart surgery immune cells under microscope
Knowledge-focused Recruiting nowThis study looks at leftover blood samples from 100 patients having heart surgery to see how certain immune cells (monocytes) change during the procedure. The goal is to understand links between inflammation and blood clotting risks. No new treatments are being tested; it is pure…
Sponsor: Boston Children's Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:08 UTC
-
Massive study tracks blood transfusions to save lives in surgery
Knowledge-focused Recruiting nowThis registry will collect detailed information from 50,000 patients who receive emergency blood transfusions during active bleeding while under anesthesia. The goal is to analyze how transfusions affect blood clotting, oxygen levels, and other vital signs. By studying this data,…
Sponsor: Erasme University Hospital • Aim: Knowledge-focused
Last updated Jun 26, 2026 12:56 UTC