Bifidobacteriales infectious disease

This study tests a new drug called GenSci142, given as a vaginal capsule, for treating bacterial vaginosis (BV). About 30 women with BV will receive either GenSci142 or a standard antibiotic cream to compare safety and how well each works. The goal is to see if the new capsule is…

This phase 2 trial tests whether transferring vaginal fluid from healthy donors can help women aged 18-25 with recurrent bacterial vaginosis (BV). Participants first receive standard antibiotics, then the transplant. The goal is to see if this restores a healthy vaginal microbiom…

This study compares two common antibiotic combinations—vancomycin with piperacillin/tazobactam versus vancomycin with meropenem—to see which is less harmful to the kidneys. About 852 hospitalized adults with serious infections will be randomly assigned to one of the two combos. T…

This study tests whether a probiotic called Lactobacillus gasseri KABP®064 can prevent bacterial vaginosis (BV) from returning after standard antibiotic treatment. BV is a common vaginal infection that often comes back within a year. The trial will involve 160 women with a histor…

This study tests whether a probiotic supplement containing Lactobacillus crispatus can reduce the number of times bacterial vaginosis (BV) comes back in women who have had it repeatedly. About 156 women aged 18-45 will take either the probiotic or a placebo daily for 12 weeks aft…

This study tests a new treatment called FB301 in 120 women aged 18-45 with bacterial vaginosis (BV). Before FB301, some women will receive an antibiotic or a vaginal wash to see if that helps restore healthy bacteria. The goal is to improve the balance of good bacteria in the vag…

This study tests a new treatment called FB301, a capsule containing beneficial bacteria, for women with an imbalance of vaginal bacteria who have had a failed frozen embryo transfer (IVF). Thirty women aged 18-40 will receive FB301 or a placebo during a mock IVF cycle, with some …

This study tests whether adding a vaginal tablet containing good bacteria and a low-dose hormone (Gynoflor®) to standard preterm labor treatment can help women stay pregnant longer. About 80 pregnant women between 24 and 33 weeks will receive either the tablet or a placebo for 6 …

This early-stage trial tests a new drug called GenSci142 in 30 healthy Chinese women to see if it is safe and how the body processes it. Participants receive a single dose of the drug or a placebo, and are monitored for side effects for 15 days. The goal is to gather safety infor…

This study will test a new diagnostic device called the Nanopath assay, which aims to quickly detect bacteria or yeast causing vaginitis. Up to 1000 women with symptoms like itching or discharge will provide vaginal swab samples, either collected by a clinician or themselves. The…

This study tests whether BPR-101 capsules, taken with the antibiotic metronidazole, can prevent bacterial vaginosis (BV) from coming back. Eighty women with BV will receive either the active treatment or a placebo. The main goal is to see if the combination lowers the rate of BV …

This study tests a medical device called Rephegyn vaginal ovules to help treat fungal (candidiasis) and bacterial infections. The device is designed to help heal the vaginal lining and reduce symptoms like discharge, pain, and itching. About 34 adults with recurrent infections wi…

This early-stage study tests whether LCFA-01, a natural gel containing oleic acid, is safe and comfortable when placed in the vagina. Thirty healthy women aged 18-40 will use the gel and be monitored for side effects, discomfort, and how much of the product enters the bloodstream…

This observational study will look at 10,000 adults in intensive care units (ICUs) around the world during a single 24-hour period. Researchers want to find out how common infections and antibiotic-resistant bacteria are, how they are treated, and how patients recover. No new tre…

This research project aims to understand why older adults get more infections and why those infections can be more serious. By following 23,000 people aged 60 and older, scientists will collect health data and samples like blood and stool to study how the immune system changes wi…

This early-stage study will give a single dose of the experimental antibiotic gepotidacin to 20 hospitalized children aged 2 to 12 who are already receiving standard antibiotics for a bacterial infection or as a preventive measure. Researchers will measure how the drug moves thro…

This study will collect blood samples from 30,000 adults in the UK with various health conditions, including blood clots, infections, heart disease, diabetes, and more. The samples will be used to develop and fine-tune new diagnostic tests for the cobas® lumira device, which allo…

This study will follow 300 adults with severe infections in the ICU to see how levels of specialized pro-resolving mediators (SPMs)—natural molecules that help stop inflammation—change over time. Researchers will use blood samples already collected during routine care, so no extr…