Bacterial arthritis

This study tests whether a single surgery to replace an infected artificial knee works as well as the standard two-surgery approach. About 153 patients with a chronic knee infection will be randomly assigned to one of the two treatments. Researchers will track pain, function, and…

This trial compares two oral antibiotics—trimethoprim-sulfamethoxazole (TMP-SMX) and clindamycin—to see which works better for children with invasive MRSA infections, such as bone, joint, or deep tissue infections. About 100 children aged 60 days to 18 years will take one of the …

This study tests a personalized virus therapy (bacteriophage) combined with antibiotics in one patient with a chronic, drug-resistant hip joint infection. The patient has no other good options left—without treatment, the infection could be fatal or require leg amputation. The goa…

This study looks at whether giving children with bone and joint infections antibiotics only by mouth works just as well as starting with IV antibiotics for a few days and then switching to pills. About 285 children aged 1 to 18 from hospitals in Australia and New Zealand will tak…

This study tests whether proteins in joint fluid, such as alpha-defensin, can quickly and accurately detect bacterial joint infections (septic arthritis) in children. Currently, doctors rely on cultures that take days, forcing tough decisions about emergency surgery. The trial co…

This study explores whether a special thermal camera can help doctors quickly detect infections in children's bones, joints, or soft tissues. About 30 children with suspected infections will have a 10-second video taken of the affected area to see if the heat pattern matches the …

This study tests whether exposure to bright blue light can reduce inflammation and organ damage in people hospitalized with serious infections like pneumonia, infected joints, or abdominal infections. Participants will be randomly assigned to receive either blue-enriched light or…

This study looks at how well the Triathlon Hinge Knee System works in people who need knee replacement surgery, either for the first time or to fix a previous one. Researchers will follow about 200 patients for up to 10 years to see how long the implant lasts and how well patient…