Autoinflammatory syndrome

This study tests whether training popular community leaders to share vaccine information can increase COVID-19 booster shots among Black individuals with rheumatic conditions like lupus. About 60 people will take part, including leaders and their social network members. The goal …

This study tests whether anakinra (Kineret), a daily injection, can reduce monthly attacks in Chinese patients with Familial Mediterranean Fever (FMF) who do not respond to standard colchicine treatment. Three patients aged 2 years and older will receive anakinra for 6 months, wi…

This early-stage trial tests an experimental drug called BI 3000202 in 16 adults with rare type 1 interferonopathies, such as Aicardi-Goutières syndrome. Participants take a low dose for 4 weeks, then a higher dose for 36 weeks. The main goal is to see if the drug is safe and how…

This phase 2 study tests a drug called MAS825 in 17 people with rare genetic conditions that cause severe inflammation. The goal is to see if the drug can prevent disease flares better than a placebo. Participants will be monitored for safety and effectiveness over several period…

This phase 3 trial looks at whether people with severe sarcoidosis who are in remission should stop or continue taking infliximab. 32 adults who have been on infliximab for at least 6 months and are stable on low-dose steroids will be randomly assigned to stop or continue the dru…

This study tests an experimental drug, BMS-986278, in about 1057 adults with progressive pulmonary fibrosis, a condition where lung scarring worsens over time. Participants receive either the drug or a placebo to see if it can slow lung function decline and is safe. The trial is …

This trial tests whether a procedure called catheter ablation works better than anti-arrhythmic drugs for people with structural heart disease who have had a dangerous fast heart rhythm (ventricular tachycardia). About 162 participants will be randomly assigned to either ablation…

This study looks at whether a combination of two antibiotics (azithromycin and doxycycline) can reduce bacteria linked to sarcoidosis and lower inflammation. About 40 adults with biopsy-confirmed sarcoidosis and active inflammation on a PET scan will receive the antibiotics or a …

This study is looking at how well the drug tofacitinib works for people with Blau syndrome, a rare genetic condition that causes inflammation in the joints, eyes, and skin. Researchers will review medical records from 24 participants to see if tofacitinib helps control the diseas…

This study tests whether sirolimus, a drug that calms the immune system, can help people with Adult-Onset Still's disease whose symptoms don't improve with standard steroids. Three adults with this rare inflammatory condition will take sirolimus pills for 12 weeks while doctors m…

This study tests an online program designed to help people with inflammatory arthritis remain employed. The program includes eLearning modules, group video sessions, and consultations with an occupational therapist and vocational counselor. About 528 participants from three Canad…

This pilot study tests whether home-based or video-supervised exercise programs are acceptable and helpful for people with chronic lung diseases like IPF, sarcoidosis, bronchiectasis, asthma, and other interstitial lung diseases. Fifty participants will be randomly assigned to on…

This study at Duke University tests whether a special MRI scan using inhaled xenon gas can detect changes in lung function over time in people with progressive pulmonary fibrosis. Sixty adults with various types of lung scarring will have MRI scans before starting anti-fibrotic m…

This study aims to create a tool that predicts which patients with inflammatory rheumatic diseases (like rheumatoid arthritis, vasculitis, or polymyalgia rheumatica) will develop serious side effects from long-term steroid use. Researchers will collect routine medical data—such a…

This registry enrolls up to 1,000 women aged 12–55 with rheumatic or autoimmune diseases who are pregnant or planning pregnancy. Researchers will collect data from medical records and patient surveys to study pregnancy outcomes, disease activity, and medication use. No experiment…

This study checks how common swallowing difficulties (dysphagia) are in people with inflammatory rheumatic diseases like rheumatoid arthritis. Researchers used questionnaires to measure swallowing function, gut symptoms, and diet quality in 191 participants. The goal is to unders…

This study follows 500 children and adults with recurrent pericarditis (repeated inflammation of the heart lining) to better understand the disease. Researchers will track which treatments patients use, how the disease affects quality of life, and the economic costs. The goal is …

This study looks at whether stressful or traumatic life events increase the chance of developing fibromyalgia. Researchers will follow 534 adults—some with rheumatic diseases and some healthy—for one year, checking for new fibromyalgia cases. The goal is to better understand how …

This study aims to understand the genetic and molecular changes in people with bone marrow failure disorders. Researchers will analyze blood and bone marrow samples from up to 1,400 participants to track how these changes evolve over time. The goal is to better predict disease ou…

This study looks at how well people with sarcoidosis take their prescribed medicines and whether that affects their disease. Researchers will follow 150 adults in Maryland and D.C. for one year, tracking lung function, symptoms, and hospital visits. The goal is to find ways to he…

This study will enroll 40 children aged 8-18 with Familial Mediterranean Fever (FMF) to see if infections trigger disease flares. Participants will use a mobile app to log symptoms like fever, cough, or sore throat in real time. The goal is to better understand the infection-flar…