Aortic valve disorder

This study tests whether the drug vericiguat can slow the buildup of calcium on the aortic valve in people with mild-to-moderate aortic valve stenosis. Participants take vericiguat or a placebo daily for 24 months, with regular heart scans to track valve calcium and function. The…

This study looks at how safe and effective the SAPIEN 3 heart valve is for people with a certain type of bicuspid aortic valve stenosis (Type-0). About 170 people in China will be observed after the procedure to track serious problems like death, stroke, or rehospitalization. The…

This registry will follow 200 people with severe aortic valve stenosis who receive a non-invasive ultrasound therapy called Valvosoft. The treatment uses focused sound waves to soften calcium buildup on the valve without surgery. Researchers will track safety and effectiveness fo…

This trial is for people whose surgically implanted aortic heart valve has stopped working properly. It compares two types of replacement valves placed through a tube in the leg (TAVI): a newer self-expanding valve (Hydra) versus standard balloon-expandable valves (Sapien or MyVa…

This study tests a new device called the J-Valve Transfemoral System in 50 adults who have a heart pump (LVAD) and a severely leaking aortic valve. The valve is replaced through a blood vessel, avoiding open-heart surgery. The goal is to see if it safely stops the leak and improv…

This registry will follow 500 adults who need surgical replacement of their aortic or mitral heart valve with a Dafodil bioprosthetic valve. The study collects real-world data on survival, valve function, and complications like blood clots or infection over 5 years. It aims to he…

This trial tests a new device called the ArcFlex Sheath, a bendable tube used during TAVR surgery to replace a faulty aortic valve. The goal is to see if it helps doctors position the new valve more easily and safely compared to a standard sheath. About 180 people who need TAVR s…

Researchers at Massachusetts General Hospital are studying whether molecular imaging and detailed biological profiling can predict how quickly aortic stenosis gets worse. The trial enrolls 100 adults with mild to moderate calcific aortic stenosis. Participants receive a baseline …

This study tests whether placing soft foam dressings on the skin before heart surgery can prevent pressure injuries (bedsores). About 80 adults having long heart surgeries will be enrolled. Researchers will check for new skin injuries after surgery and track how severe they are. …

This study will examine how the heart-lung machine used during cardiac surgery changes platelet function and metabolism. Researchers will take blood samples from 100 adult heart surgery patients at several time points. The goal is to link these platelet changes to post-surgery in…