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PET scans may reveal which aortic valves will worsen

NCT ID NCT07819344

Diagnosis Sponsor: Massachusetts General Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 14, 2026 · Last updated Sep 17, 2026 · Updated 3 times

Summary

Researchers at Massachusetts General Hospital are studying whether molecular imaging and detailed biological profiling can predict how quickly aortic stenosis gets worse. The trial enrolls 100 adults with mild to moderate calcific aortic stenosis. Participants receive a baseline PET/CT scan to measure active calcification in the valve, and researchers use multi-omics data to build prediction models. Follow-up imaging after one year tracks changes in the valve to see if the baseline measures match the rate of progression.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
18F-sodium fluoride PET/CT imaging
What this could lead to
If it works, this could give doctors a way to predict whose aortic stenosis will worsen quickly, helping them plan treatment earlier.
What could go wrong
The study is small and observational, so the prediction models may not hold up in larger or different groups. PET/CT also involves radiation exposure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Mar 2031

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

100 subjects with mild or moderate aortic stenosis

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Males and females * aged 18 years or older * mild to moderate calcific Aortic Stenosis (as defined by standard echocardiographic criteria) Exclusion Criteria: * Bicuspid Aortic Stenosis * pregnancy * cognitive disabilities that impair the ability to comply with instructions or provide informed consent * any other medical condition that may undermine participation * weight \>300 lbs * severe claustrophobia * Pregnancy * subjects who have had significant radiation exposure as part of research (\>2 nuclear tests, computed tomography images, or fluoroscopic procedures) during the preceding 12 months * Individuals with renal dysfunction (eGFR\<55) or a history of allergic reaction to iodinated contrast will not receive the iodinated contrast.

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Conditions

The condition(s) this trial relates to.

Aortic Valve Disease aortic valve disorder aortic valve stenosis calcinosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aortic valve diseases Calcification; heart

How to take part

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  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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  2. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

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