Anodontia

This trial compares two types of full-arch dental implant frameworks—one made from a single piece of zirconia and the other from titanium with a zirconia top—in people who have lost all teeth in one or both jaws. The goal is to see which material leads to fewer mechanical problem…

This study tests three common cleaning aids—superfloss, interdental brushes, and a water flosser—in 18 adults with full-arch implant-supported dentures. Each person uses one method for three months, then switches to the next, so everyone tries all three. The goal is to find which…

This study tests a fully digital method for full-mouth dental rehabilitation in 10 adults aged 20-45 with bite problems, missing teeth, or smile concerns. The approach uses 3D scans of the teeth, face, and jaw to plan treatment, which may include tooth movement, guided implant pl…

This study tests whether a gel made from enamel proteins can thicken gum tissue around dental implants. Researchers will measure gum thickness in 32 adults who need implant uncovering surgery. The goal is to see if this treatment improves gum health and implant stability.

This study compares two ways of making full dentures for people who have lost all their teeth. One method uses digital scans and 3D printing, while the other combines traditional impressions with digital design. Twenty participants will try both types of dentures for two months e…

This study looks at whether doing breathing exercises before orthopedic surgery (like knee, hip, or fracture repair) can help your lungs work better after the operation. It involves 36 adults who have used tobacco and are at risk for breathing problems after surgery. Participants…

This study follows 100 people who are getting full-arch dental implants (replacing all teeth in one jaw). Researchers want to see how the treatment changes their oral health-related quality of life—things like eating, speaking, and feeling confident. Participants answer questionn…

This study tests whether a program of exercise and ergonomics training can reduce muscle and joint pain in teachers. About 80 teachers who have had pain for at least three months will be randomly assigned to receive the training or not. Researchers will measure changes in pain, d…

This study compares two ways to secure lower dentures: using one implant or two implants. Researchers want to see if one implant can provide similar comfort, satisfaction, and chewing ability as two implants. The study involves 32 adults with no teeth who already have upper and l…

This study tests a web-based app called IAMABLE that provides evidence-based rehabilitation strategies for people with chronic conditions like heart disease, arthritis, or neurological disorders. Fifty adults aged 45 to 75 will use the app for 4 months to set goals and learn abou…

This study tests whether extra support for case managers helps veterans leaving the military better manage pain and reduce risky substance use. About 1800 veterans will take part. The program focuses on non-drug pain treatments and counseling.

This study looks at how the types of bacteria in the mouth change in people with severe gum disease as they go from having some teeth left to having no teeth, and then after getting dental implants. Researchers will collect microbial samples and analyze DNA to see if different im…

This study aims to learn more about rare skeletal disorders by collecting medical records, blood samples, and genetic data from 100 participants. People with known or suspected bone conditions, as well as their healthy family members, can join either remotely or in person. The go…

This study translates and tests several health questionnaires—covering pain, arm and leg function, mood, and daily activities—for use with Albanian-speaking people. Researchers will check if the translated versions are reliable and accurate by giving them to about 300 participant…

This study tests a new tool called the PRISM Dashboard, which gives physiotherapists feedback on how their decisions compare to their peers. The goal is to see if this feedback helps reduce differences in care for people with muscle and joint pain. About 60 physiotherapists and t…

This study looks at how well dental implants heal in people taking TNF-alpha inhibitors (a type of arthritis medication). Researchers will compare 15 patients on these drugs with 15 similar patients not taking them. Participants will get implants and be followed for a year with e…

This study follows 252 adults with muscle, bone, or joint problems (like arthritis, back pain, or after surgery) to see how well they do their prescribed home exercises. Researchers will track who sticks with the program and why, looking at factors like pain, mood, and support. T…

This study tests whether using a virtual reality (VR) headset during shoulder exercises helps patients feel more engaged and motivated. Fifty adults with shoulder problems will do rehab exercises in a VR environment and then answer questionnaires about how easy and immersive the …

This study aims to create a secure national database for muscle and joint (musculoskeletal) conditions by collecting routine data from community clinics and GP practices. About 22,000 adults will have their information anonymously gathered to help develop a dashboard that tracks …

This study tests whether a digital intraoral scanner can capture the shape of the mouth as accurately as the traditional border-molded impression method for making complete dentures. Ten adults who have lost all their teeth will get both types of impressions, and researchers will…

This study watches 2000 people having hip or knee replacement surgery to see how long spinal anaesthesia lasts. The goal is to learn how the amount of anaesthetic affects timing, helping doctors decide if patients can safely go home the same day. No new treatments are tested—just…

This study looks at how quickly people can bite and slide their teeth when wearing a lower denture held in by either two regular-sized implants or four smaller mini-implants. Researchers will measure the time it takes to close the bite and to slide the teeth apart. The goal is to…

This study looks at how changing the heel cushion on an ankle-foot brace (AFO) affects walking in people who use one daily. Forty adults with leg injuries or nerve problems will try four different heel wedges—tall or short, soft or firm—while walking at controlled speeds. Researc…

This study looks at how 3D computer simulation and printing can help surgeons better plan and perform bone correction surgeries. Researchers will compare the planned corrections to the actual results in 100 children and young adults with rare bone deformities. The goal is to make…

This study looks at how losing all your teeth and getting dentures affects your sense of taste, touch in the mouth, and food likes. Researchers will compare 40 people who have worn dentures for at least a year with 40 people who still have their natural teeth. The goal is to unde…

This study follows 4,000 children who receive orthopedic implants (like rods or screws) during standard care for bone fractures, deformities, or hip problems. Researchers will track how long the implants last, any complications, and how well they work over time. The goal is to ga…

This study is building a registry of people with rare bone diseases (skeletal dysplasias) in Italy. Researchers will collect medical history, genetic data, and treatment details over time to better understand how these conditions progress. No experimental treatments are given; th…

This study follows 144 adults with muscle or bone problems who are already scheduled to receive treatment with Chattanooga Intelect devices (like TENS or ultrasound). Researchers will measure pain, muscle strength, and movement range to confirm the devices are safe and work as ex…