Adrenocortical insufficiency
MONDO:0000004An endocrine or hormonal disorder that occurs when the adrenal cortex does not produce enough of the hormone cortisol and in some cases, the hormone aldosterone. It may be due to a disorder of the adrenal cortex (Addison's disease or primary adrenal insufficiency) or to inadequate secretion of ACTH by the pituitary gland (secondary adrenal insufficiency).
Also known as: adrenal cortical hypofunction, adrenal cortical insufficiency, adrenal gland insufficiency, adrenal insufficiency, adrenocortical insufficiency, hypocortisolemia, hypocortisolism, hypoadrenalism
78 clinical trials for this condition and its sub-types, 33 tagged with Adrenocortical insufficiency itself.
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Sub-types of Adrenocortical insufficiency
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Primary adrenal insufficiency 5 trials · 48 incl. sub-types
2 sub-types
- Chronic primary adrenal insufficiency 6 trials · 47 incl. sub-types Sub-types →
- Acute adrenal insufficiency 0 trials Sub-types →
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Secondary adrenal insufficiency 3 trials
Most studied deeper sub-types
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Can adding a second steroid improve survival in severe sepsis?
Disease control CancelledThis trial compares two treatments for people with severe sepsis who also have adrenal insufficiency, a condition where the adrenal glands do not make enough cortisol. Researchers test whether giving fludrocortisone along with hydrocortisone works better than hydrocortisone alone…
Phase 4 • Sponsor: CAMC Health System • Aim: Disease control
Last updated Sep 02, 2026 00:00 UTC
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Could a Once-Daily steroid pill improve blood sugar control in Dual-Disease patients?
Disease control CancelledThis trial tests whether taking hydrocortisone once a day (as a dual-release pill) leads to more stable blood sugar levels compared to the standard three-times-a-day regimen in adults who have both insulin-treated diabetes and Addison's disease. Participants will try both schedul…
Sponsor: Vastra Gotaland Region • Aim: Disease control
Last updated Jul 09, 2026 00:00 UTC
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New drug combo aims to tame Cushing's disease with fewer side effects
Disease control By invitation onlyThis study tests whether adding cabergoline to osilodrostat works better than osilodrostat alone for controlling Cushing's disease. About 50 adults with active Cushing's disease will receive either the combination or the single drug. The goal is to see if the combo can lower cort…
Phase 4 • Sponsor: University of Basrah • Aim: Disease control
Last updated Jun 27, 2026 12:37 UTC
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New imaging methods could transform PMR diagnosis
Diagnosis OngoingThis study explores whether ultrasound and PET/CT scans can more accurately diagnose and monitor polymyalgia rheumatica (PMR), a condition causing muscle pain and inflammation. Researchers will follow 98 adults over 50 suspected of having PMR, using imaging at key points during t…
Sponsor: Kresten Krarup Keller • Aim: Diagnosis
Last updated Jun 27, 2026 07:51 UTC
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Quick therapy after rape may stop PTSD before it starts
Prevention OngoingThis study tests whether a short, modified exposure therapy given soon after rape can prevent post-traumatic stress disorder (PTSD) in women. About 166 women who have experienced sexual assault will be randomly assigned to either the brief therapy or standard care. The goal is to…
Sponsor: St. Olavs Hospital • Aim: Prevention
Last updated Jun 27, 2026 12:30 UTC
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Can a blood test predict who will get diabetes from steroids?
Knowledge-focused OngoingThis study aims to find genetic and metabolic markers that explain why some people develop diabetes, high blood pressure, or bone loss from glucocorticoids while others do not. Researchers will analyze blood and urine samples from up to 600 participants, including those with exce…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:35 UTC