Adjustment disorder

This phase 2 trial at MD Anderson Cancer Center is testing whether psilocybin-assisted psychotherapy can safely help ease depression and anxiety in 30 adults with advanced cancer who are on maintenance therapy. Participants receive either psilocybin or a placebo (niacin) along wi…

This study tests whether a single injection of RE104 can reduce symptoms of depression or mixed depression and anxiety in people with adjustment disorder caused by a serious medical illness like cancer, ALS, multiple sclerosis, Parkinson's disease, or idiopathic pulmonary fibrosi…

This study looks at whether teaching people with a colostomy or ileostomy how to care for their stoma helps them adjust better, feel better about their body, and manage their daily life. About 100 adults who had planned stoma surgery will take part. The goal is to see if educatio…

This study tests whether psilocybin, the active ingredient in magic mushrooms, combined with talk therapy can safely help cancer survivors with depression or anxiety. Twenty adults who have finished cancer treatment and have no brain involvement will receive a single dose of psil…

This study tests whether MDMA (the drug in ecstasy) combined with talk therapy can help cancer patients and their partners who are struggling with adjustment disorder—a condition where they have trouble coping with the cancer diagnosis. Twenty participants (10 patient-partner pai…

This pilot study at Mayo Clinic is testing whether a single 20-30 minute virtual reality session can safely reduce anxiety, depression, and fatigue in cancer patients. 24 adults undergoing chemotherapy or bone marrow transplant will try calming VR experiences like nature walks or…

This study tests whether a single dose of NPX-5 (a psilocybin drug) combined with talk therapy can reduce severe anxiety in people who have trouble adjusting to a cancer diagnosis. About 87 adults aged 18–80 with moderate-to-severe anxiety will receive one of three doses (25 mg, …

This pilot study will test a brief cognitive-behavioral resilience training program for 60 adults who have been on parole for two years or less and are having trouble adjusting. The goal is to see if the program is practical and helpful in reducing stress and improving well-being…

This study follows people who received inpatient treatment for stress-related conditions like depression, adjustment disorder, or burnout. Researchers will track their health and work ability for up to three years after discharge, using online questionnaires. The goal is to under…

This study aims to validate a new questionnaire (ADNM-20-Mil) designed to better diagnose adjustment disorders in active-duty US military personnel. It also pilots a device called SANA, which uses light and sound pulses to promote relaxation. Sixty participants with a recent adju…

This study tests whether a device called rTMS, which uses magnetic pulses to temporarily change brain activity, can alter how people with anxiety respond to fearful situations. Researchers will measure brain signals and reactions in 80 adults who recently started anxiety treatmen…

This study tests whether combining a one-time session of brain stimulation (rTMS or electrical scalp stimulation) with emotion regulation training helps people with mood, anxiety, or related disorders better control their emotions. 240 participants will learn either cognitive res…

This study tests whether a technology called transcranial focused ultrasound (tFUS) can temporarily change brain activity linked to anxiety. Researchers will recruit 40 adults with anxiety disorders who recently started treatment. Participants will undergo brain imaging and then …