Adenoviridae infectious disease

This trial is testing an experimental drug called brincidofovir, given intravenously, in people aged 2 months and older who have an adenovirus or cytomegalovirus infection. The study aims to see how safe and tolerable different doses are, and whether the drug can reduce the amoun…

This early-stage trial tested a modified virus called TILT-123 in 32 people with advanced solid tumors that had not responded to standard treatments. The virus is designed to infect and kill cancer cells while releasing immune-boosting proteins. The main goal was to check safety …

This study tested a modified cold virus called LOAd703 in 51 people with pancreatic cancer. The virus is designed to infect and kill cancer cells while also boosting the immune system. It was given alongside standard chemotherapy, and in some cases an immunotherapy drug, to see i…

This study tested a new eye gel called IVIEW-1201 in 135 people with acute adenoviral conjunctivitis (pink eye caused by a virus). The goal was to see if the gel could clear symptoms like redness and discharge faster than a placebo. The gel contains povidone-iodine, an antiseptic…

This study tested whether giving patients special immune cells (T cells) that target CMV or adenovirus could control these infections after a stem cell transplant. Sixteen children and adults received one or two doses of these cells. The goal was to reduce virus levels in the blo…