Acute respiratory failure

This study tests an experimental drug called Auxora in 150 adults with acute kidney injury and breathing failure. Patients receive either Auxora or a placebo daily for five days. The goal is to see if Auxora helps patients survive, breathe without a machine, and avoid kidney dial…

This phase 3 trial tests whether an inhaled combination of budesonide (a corticosteroid) and formoterol (a bronchodilator) can prevent acute respiratory failure in hospitalized adults with pneumonia and low blood oxygen levels. Participants receive either the active treatment or …

This trial tests whether high-flow nasal cannula oxygen or noninvasive ventilation works better than standard oxygen therapy for ICU patients with acute respiratory failure. About 1,470 adults will be randomly assigned to one of the three methods. The main goal is to see which ap…

This phase 3 trial tested whether the antiviral drug ganciclovir could prevent reactivation of cytomegalovirus (CMV) in adults with sepsis who needed a breathing machine. The study enrolled 205 CMV-positive patients in the ICU with acute respiratory failure. Participants received…

This study tested an experimental drug called ABX464 in 509 high-risk COVID-19 patients aged 65 and older, or those 18+ with risk factors like obesity or diabetes. The goal was to see if the drug could reduce inflammation and prevent the need for high-flow oxygen or a breathing m…

This study tested whether using lung ultrasound to adjust ventilator pressure could improve oxygen levels in people with blunt chest trauma. Nineteen adults with rib fractures or lung bruises who needed breathing support were enrolled. The trial was terminated early, so the findi…

This study compared two types of non-invasive breathing support for people with sudden breathing failure who are obese or have sleep apnea. One machine automatically adjusts pressure and volume, while the other uses a fixed pressure setting. The goal was to see which method clear…

This study tested a negative pressure vest (Biphasic Cuirass Ventilation) to see if it works as well as standard breathing masks for patients hospitalized with acute hypercapnic respiratory failure (high carbon dioxide levels). The trial planned to enroll 50 adults, but it was te…

This study tested a device that delivers warm, moist air through the nose to help people with breathing failure who did not have too much acid in their blood. The goal was to see if it could prevent their condition from getting worse. Only 16 people took part, and the study was s…