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127005 trials found · Page 6150 of 6351
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Spine surgery breathing study: does position matter for lung health?
Knowledge-focused CompletedDuring mechanical ventilation, the alveolar recruitment maneuver (ARM) is to apply a positive end-expiratory pressure (PEEP) (generally 30 cm H2O) for a period of at least 30 seconds. The realization of MRA is one of three main elements of mechanical ventilation called "protectiv…
Sponsor: University Hospital, Strasbourg, France • Aim: Knowledge-focused
Last updated Jun 26, 2026 13:32 UTC
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Radiation's hidden impact: mouth viruses under the microscope
Knowledge-focused CompletedThe treatment of otolaryngology (OLR) cancer is based on surgery, radiation, sometimes used in combination with chemotherapy. Patients treated with radiotherapy have multiple oral diseases: mucositis, hyposalivation, tissue fibrosis, exacerbation of periodontitis. Over 70% of pat…
Sponsor: Centre Hospitalier Universitaire de Nice • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:00 UTC
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Vitamin e study aims to uncover how body fat affects nutrient needs in women
Knowledge-focused CompletedBackground: * Vitamin E is an antioxidant that reduces the damaging effects of oxygen in the body. Most American men (90%) and women (96%) do not get enough vitamin E from their diets; however, the amount of vitamin E needed by the body has been studied only in men, not women. I…
Phase 1 • Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) • Aim: Knowledge-focused
Last updated Sep 03, 2026 00:00 UTC
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Scientists probe why older skin turns cancerous
Knowledge-focused CompletedEpidemiological data show that the incidence of carcinoma, the most common cancer, is strongly linked to the age. Non Melanoma Skin Carcinomas (NMSCs) (the most frequent cancers in the elderly population) derive from keratinocytes of the basal layer of the epidermis, from differe…
Sponsor: Centre Oscar Lambret • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:03 UTC
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Parkinson's and perfectionism: a hidden link?
Knowledge-focused CompletedScientific studies show that almost half of the people with Parkinson's Disease (PD) suffer of depression and / or anxiety.
Sponsor: Centre Hospitalier Universitaire, Amiens • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:06 UTC
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Zap to talk: brain stimulation tried for aphasia after stroke
Symptom relief Stopped earlyThe aim of this work is to study the effect of transcranial direct current stimulation combined with naming therapy in acute and post-acute stroke comparing four bihemispheric positioning electrodes to a sham condition.
Sponsor: Institut National de la Santé Et de la Recherche Médicale, France • Aim: Symptom relief
Last updated Jun 26, 2026 13:31 UTC
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Massive data dive on elderly cancer patients reveals care gaps
Knowledge-focused CompletedThe aim of this study is to establish a common geriatric oncology medical database. The patients concerned are the patients having benefited from a geriatric oncology consultation in one of the participating centres. This database is designed with a view on the one hand to better…
Sponsor: Centre Oscar Lambret • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:02 UTC
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Blood clot registry aims to uncover hidden risk factors
Knowledge-focused CompletedPatients with an episode of VTE (DVT and / or PE) have a mortality rate of 16-21% at 1 year after diagnosis. Morbidity associated with VTE is marked by the risk of recurrence, estimated at 30% and estimated at 29% after 8 years of follow post-thrombotic syndrome. For a number of …
Sponsor: University Hospital, Strasbourg, France • Aim: Knowledge-focused
Last updated Jun 26, 2026 14:03 UTC
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Frailty may predict return of rectal prolapse after surgery
Knowledge-focused Completedevaluate recurrent RP in relation to frailty
Sponsor: Zagazig University • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:58 UTC
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Can your personality change your diabetes genes?
Knowledge-focused Stopped earlyThis study will include 100 patients with Type 1 and Type 2 diabetes, split into 2 groups of 50 patients according to their behaviour type, and their adaptation to different factors of stress encountered in their lives: * the first group will consist of patients with a character…
Sponsor: Centre Hospitalier Universitaire Dijon • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:03 UTC
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Can a simple throat device strengthen your swallow?
Knowledge-focused Recruiting nowThis study of healthy young and elderly individuals is intended to assess the effects of pharyngeal exerciser on pharyngeal pressure phenomenon during swallowing. Our specific aim is to test if the pharyngeal exerciser increases the workload of muscles involved in pharyngeal phas…
Sponsor: Medical College of Wisconsin • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:11 UTC
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Healthy brain scans could sharpen epilepsy surgery
Knowledge-focused CompletedEpilepsy is the most common chronic neurological disorder in the world, affecting more than 50 million people worldwide. Approximately 35% of patients with epilepsy are refractory to all available antiepileptic drugs. Focal Hypometabolism on interictal \[18F\]-FDG PET is a hallm…
Sponsor: Hospices Civils de Lyon • Aim: Knowledge-focused
Last updated Jun 26, 2026 17:21 UTC
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Could new CT scans use less radiation without losing clarity?
Knowledge-focused Recruiting nowBackground: \- Computed Tomography (CT) is a scan that makes detailed pictures of the body. It uses radiation to do that. In 2011, about 85.3 million CT scans were done in the United States. But there is growing concern about the health effects of radiation. There are new and di…
Sponsor: National Heart, Lung, and Blood Institute (NHLBI) • Aim: Knowledge-focused
Last updated Aug 09, 2026 00:00 UTC
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VA launches major effort to understand gulf war Veterans' health
Knowledge-focused OngoingThe Gulf War Era Cohort and Biorepository pilot project collected epidemiological, survey, clinical, and environmental exposure data from Veterans who served during the 1990-1991 Gulf War Era. Approved researchers will be able to use these data and the blood samples to do future …
Sponsor: VA Office of Research and Development • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:25 UTC
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Mind the gap: study reveals how patient and surgeon expectations differ before spine surgery
Knowledge-focused OngoingThe goals of this study are to assess concordance between the patient-surgeon pair regarding expectations of lumbar spine surgery.
Sponsor: Hospital for Special Surgery, New York • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:04 UTC
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Genetic treasure hunt: 3600 patients help decode disease genes
Knowledge-focused Recruiting nowCollection of coded biomaterial and clinical data with patients consent for future research.
Sponsor: Maastricht University Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:54 UTC
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Your cell phone could reveal your Body's hidden clock
Knowledge-focused CompletedAs citizens of the information age, humans leave digital traces of behavior in their communication and movement patterns through our cell phone. The Global Positioning System (GPS) technology tracks the way persons commute to school or work or when visiting family and friends. Ci…
Sponsor: University of Pennsylvania • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:02 UTC
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Schizophrenia and smiles: new study checks teeth
Knowledge-focused CompletedThe aim of this study is to know the bucco-dental status of patients with schizophrenia in Côte d'Or. Participation in this study will last only as long as it takes to: * carry out a bucco-dental examination: evaluation of dental plaque and calculus * take a blood sample to ass…
Sponsor: Centre Hospitalier Universitaire Dijon • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:03 UTC
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Early walking after heart procedure may be safe and more comfortable
Symptom relief CompletedThe researchers are seeking to study whether or not there is benefit in keeping patients flat after Angioseal for extended periods of time after diagnostic heart catheterization or if a more aggressive approach of early ambulation would be just as safe while improving cost and pa…
Sponsor: Henry Ford Health System • Aim: Symptom relief
Last updated Jun 27, 2026 08:05 UTC
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New breathing monitor tested in kids
Knowledge-focused Recruiting nowThis study will clinically evaluate a newly developed respiratory monitor - pneuRIP. The pneuRIP uses Respiratory Inductance Plethysmography (RIP) bands to measure key breathing indices non-invasively. This study compares the pneuRIP to an existing Respitrace system (Carefusion, …
Sponsor: Nemours Children's Clinic • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:58 UTC