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127005 trials found · Page 6136 of 6351
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Nausea drug may unlock new hypertension treatment in diabetes
Knowledge-focused CompletedAldosterone regulation is mediated by hormonal control, and nervous control. Autonomic nervous system action could be mediated by neuropeptides in the adrenal gland. Therefore, in pathological conditions and especially in diabetes, low-renin hypertension with normal or high plasm…
Phase 2 • Sponsor: University Hospital, Rouen • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:00 UTC
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ADHD Drug's secret power: boosting motivation in healthy brains?
Knowledge-focused CompletedThe purpose of this study is to evaluate the impact of methylphenidate, a mixed dopaminergic and noradrenergic agent, onto the different components of motivation: decision-making, effort allocation and instrumental learning.
Early phase 1 • Sponsor: Institut National de la Santé Et de la Recherche Médicale, France • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
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Tiny study probes whether viruses trigger stubborn hives
Knowledge-focused CompletedBlood samples from urticaria patients will be analyzed for viral particles
Sponsor: HaEmek Medical Center, Israel • Aim: Knowledge-focused
Last updated Jun 26, 2026 17:04 UTC
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Oxygen levels during surgery: does more help or hurt?
Knowledge-focused CompletedThis single-center randomized interventional study evaluated the biological effects of two perioperative oxygen strategies in adults undergoing elective laparoscopic lower abdominal surgery under standardized general anesthesia. Participants were assigned to receive either normox…
Sponsor: Istanbul University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:06 UTC
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Scientists dig into DNA of moles to uncover hidden mutations
Knowledge-focused Recruiting nowThe objective of this protocol is to further elucidate the genetic mutations that drive melanocytic nevi (benign melanocytic neoplasms, moles). This will be performed by whole genome, whole exome, or targeted sequencing of de-identified specimens. Herein, the investigators plan …
Sponsor: University of California, Davis • Aim: Knowledge-focused
Last updated Jun 26, 2026 17:29 UTC
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New study tracks Real-World hearing device outcomes
Knowledge-focused Recruiting nowThis Registry represents a non-interventional systematic collection of clinical data in which prospective data from children and adults are collected as fully anonymized data sets, derived from original clinical records on appropriately informed subjects. This is a patient-outco…
Sponsor: MED-EL Elektromedizinische Geräte GesmbH • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:06 UTC
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Stepping up asthma care: new test may replace treadmill
Knowledge-focused CompletedAsthma is a chronic respiratory disease that can negatively affect exercise tolerance and functional capacity due to airway inflammation, variable airflow limitation, and symptom-related activity avoidance. Reduced physical activity levels and exercise-induced symptoms often lead…
Sponsor: Gazi University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:01 UTC
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Shoulder exercises may boost collarbone motion in teens
Symptom relief CompletedThis study was planned to indicate efficiacy of the scapular stabilization exercises on the clavicula movements.
Sponsor: Gaziantep Islam Science and Technology University • Aim: Symptom relief
Last updated Jun 26, 2026 12:35 UTC
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Painkiller study hopes to speed up hospital discharge after surgery
Symptom relief Stopped earlyStudy Objective The aim of the proposed study is to examine the effect of Q4 hour multidose IV acetaminophen on patients' readiness for discharge. In doing so the investigators will also investigate the various factors that could potentially contribute to a patient's readiness fo…
Phase 4 • Sponsor: Rutgers, The State University of New Jersey • Aim: Symptom relief
Last updated Jun 27, 2026 13:04 UTC
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Warm or not? study tests tube softening for gentler nasal intubation
Knowledge-focused CompletedEpistaxis or post-pharyngeal bleeding is the most common complication after nasotracheal intubation (NTI). Prior thermal softening of the endotracheal tube (ET) has been recommended as one of the methods to prevent nasal trauma from nasotracheal intubation. However, thermal softe…
Sponsor: Hallym University Kangnam Sacred Heart Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:00 UTC
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New eye scanner could sharpen cataract surgery precision
Knowledge-focused CompletedThe primary objective of this clinical trial is to assess the clinical performance of the investigational device. To that end, for each measure and the in-vivo repeatability will be quantified, as well as the mean measurement deviation with respect to the current gold standard de…
Sponsor: Haag-Streit AG • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:02 UTC
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New study aims to make your fillings last longer and look better
Symptom relief OngoingTreatment clinical trial, randomized, controled, parallel, double-blinded, with four groups, that aims to evaluate the best application strategy when using a Universal Adhesive system, Single Bond Universal (3M ESPE, USA), in self-etch application mode, with or without enamel etc…
Sponsor: Universidade Federal Fluminense • Aim: Symptom relief
Last updated Jun 27, 2026 12:33 UTC
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Tiny brain wave study aims to sharpen Alzheimer's drug testing
Knowledge-focused Stopped earlyIn the perspective to better evaluate the efficacy of new treatment strategies for Alzheimer disease (AD), it appears important to develop experimental paradigms to precisely measure cognitive endpoints/biomarkers that may be used in healthy volunteers as tools to validate drug e…
Sponsor: University Hospital, Lille • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:37 UTC
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Researchers build database to track APS and lupus patients
Knowledge-focused CompletedThe purpose of that register is to collect medical information about patients suffering of APS with or without associated SLE.
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:58 UTC
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Tartar showdown: new toothpaste takes on regular fluoride
Disease control CompletedTo evaluate the comparative clinical efficacy of a test toothpaste containing 0.454% stannous fluoride as compared to a regular fluoride toothpaste containing 0.76% sodium monofluorophosphate in controlling supragingival calculus formation over a 12-week period.
Phase 2/3 • Sponsor: Colgate Palmolive • Aim: Disease control
Last updated Jun 27, 2026 08:03 UTC
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Why some ICU patients Can't leave the ventilator: diaphragm weakness under the microscope
Knowledge-focused Stopped earlyVentilator-induced diaphragmatic dysfunction appears to contribute to slow weaning from mechanical ventilation. Several trials of inspiratory muscle training to facilitate weaning in intensive care have been performed, with inconsistent results, utilizing different methods of IMT…
Sponsor: University Hospital, Bordeaux • Aim: Knowledge-focused
Last updated Jul 02, 2026 00:00 UTC
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Researchers watch and learn: liver transplant outcomes for cancer patients
Knowledge-focused OngoingThis is a registry study examining patients with HCC undergoing liver transplantation including outcomes and predictors of recurrence
Sponsor: Federico Aucejo • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:11 UTC
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Scientists watch tremors up close to unlock brain secrets
Knowledge-focused CompletedBackground: Researchers have some data on how the brain controls movement and why some people have tremor. But the causes of tremor are not fully known. Researchers want to study people with tremor to learn about changes in the brain and possible causes of tremor. Objective: T…
Sponsor: National Institute of Neurological Disorders and Stroke (NINDS) • Aim: Knowledge-focused
Last updated Aug 19, 2026 00:00 UTC
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Essure vs. laparoscopic sterilization: which has fewer side effects?
Knowledge-focused CompletedThis study is designed to assess post-procedural outcomes for women who chose to undergo either hysteroscopic sterilization (Essure®) or laparoscopic tubal sterilization, including: * Pelvic and/or lower abdominal pain * Abnormal uterine bleeding * Surgical intervention (includi…
Sponsor: Bayer • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:37 UTC
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Timing of pain prescriptions may affect Post-Surgery comfort
Knowledge-focused CompletedThis study evaluates the comparison of the incidence of postoperative home pain after ambulatory surgery with general anesthesia between a group with pre-surgical prescription delivered during anesthesia preoperative clinic and a group with postoperative prescription.
Sponsor: University Hospital, Rouen • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:10 UTC