Oxygen levels during surgery: does more help or hurt?

NCT ID NCT07525661

Completed Knowledge-focused Sponsor: Istanbul University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at how different oxygen levels during laparoscopic lower abdominal surgery affect stress markers in the lungs and blood. 76 adults were randomly assigned to receive either normal (35%) or high (80%) oxygen during surgery. Researchers measured changes in various biomarkers related to lung injury, inflammation, and blood vessel health.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: oxygen (hyperoxia vs normoxia)
What this could lead to: If it works, this could help guide oxygen use during surgery to reduce stress on the lungs and blood vessels.
What could go wrong: This is a small, completed study that only measured biological markers, not patient outcomes. Results may not change practice without larger trials.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Hyperoxia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ENDOTHELIAL GLYCOCALYX INJURY HYPEROXIA OXIDATIVE STRESS PERIOPERATIVE CARE

Contacts and locations

Locations

Istanbul University, Istanbul Faculty of Medicine

Istanbul, Turkey (Türkiye)

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