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127005 trials found · Page 5726 of 6351
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Social hardship linked to late breast cancer detection
Knowledge-focused CompletedThe main objective of this study is to estimate of the link (odds ratio) between the precariousness defined by the score SPICE (2 groups: precarious and insecure) and stage at diagnosis (2 groups: CAS: stages 1 or 2 the "good prognosis "versus the witnesses: stage 3 or 4 bad prog…
Sponsor: Centre Hospitalier Universitaire de Nīmes • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:58 UTC
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Can a simple booklet help cancer patients ask the right questions?
Knowledge-focused CompletedProspective, randomized, multicentre phase III study to evaluate the level and type of information requested by patients or families during a palliative care consultation after they have been given the Booklet-Question List (BQL).
Sponsor: Institut Curie • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:59 UTC
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New eye drop battle: can ectoin beat hyaluronic acid for dry eyes?
Symptom relief CompletedThis is a comparative, open label, parallel group, non interventional study to further demonstrate the efficacy and tolerability of BAT04. In addition the efficacy and safety shall be compared to Hyaluronic acid (HA)-Product. The patient applies BAT04 or HA-Product according to t…
Sponsor: Bitop AG • Aim: Symptom relief
Last updated Jun 27, 2026 09:00 UTC
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New hope for nerve pain: extending Ketamine's benefits
Symptom relief CompletedThe aim of this study is to evaluate if memantine or dextromethorphan gave in relay to ketamine maintains or induces a decrease of pain intensity. In clinical, after ketamine cure, clinicians have often difficulties to treat patients in order to maintain analgesia or suggest ano…
Phase 2 • Sponsor: University Hospital, Clermont-Ferrand • Aim: Symptom relief
Last updated Jun 27, 2026 12:23 UTC
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New drug MP-214 tested for Long-Term schizophrenia control
Disease control CompletedThe objective of this study is to evaluate the long-term safety, tolerability, and efficacy of MP-214 in patients with receiving multiple drugs schizophrenia.
Phase 2/3 • Sponsor: Tanabe Pharma Corporation • Aim: Disease control
Last updated Jun 27, 2026 08:08 UTC
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500,000 volunteers sought for Alzheimer's research registry
Knowledge-focused Recruiting nowThe Alzheimer's Prevention Registry (www.endALZnow.org) will collect contact and demographic information on individuals. The objective is to provide information the latest news and advances in Alzheimer's prevention research, and to inform enrollees about research studies in thei…
Sponsor: Banner Health • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:04 UTC
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Scientists unravel mysteries of puberty and fertility hormone
Knowledge-focused CompletedBackground: \- The body produces gonadotropin-releasing hormone (GnRH) about every 2 hours. GnRH travels through the bloodstream to the pituitary gland, where it stimulates the gland to produce hormones called gonadotropins. These hormones stimulate the testicles or ovaries. The…
Sponsor: National Institute of Environmental Health Sciences (NIEHS) • Aim: Knowledge-focused
Last updated Sep 09, 2026 21:00 UTC
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Scientists hunt for genes behind puberty problems
Knowledge-focused Recruiting nowBackground: \- During puberty, children begin to develop into adults. Problems with the hormones released during puberty can affect the reproductive system. Some people have low hormone levels that severely delay or prevent puberty. Others start puberty abnormally early. Other p…
Sponsor: National Institute of Environmental Health Sciences (NIEHS) • Aim: Knowledge-focused
Last updated Jul 30, 2026 00:00 UTC
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Could a cooler room help you burn more calories? scientists investigate.
Knowledge-focused CompletedBackground: \- The way that the body burns calories is known as energy expenditure. Some studies show that when we are cold, we burn more calories to keep our bodies warm. Brown fat is a special kind of fat that can use energy to keep the body warm. Small animals and infants hav…
Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) • Aim: Knowledge-focused
Last updated Aug 29, 2026 00:00 UTC
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Could low vitamin d in early pregnancy predict preeclampsia?
Knowledge-focused CompletedHypothesis : Vitamin D serum concentration is decreased in the first trimester in pregnant women who will develop preeclampsia in the second or third trimester compare to a control group Primary purpose : To determine the vitamin D status in the first trimester in a large populat…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:58 UTC
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Computer-Guided hip surgery aims for better fit, fewer dislocations
Symptom relief CompletedComputer assistance in prosthetic hip surgery is able to improve the accuracy of the surgery: Associating hip navigation and EOSTM imaging pre-operatively could simplify the procedure of hip navigation in lateral decubitus while maintaining the accuracy of the technique
Sponsor: University Hospital, Bordeaux • Aim: Symptom relief
Last updated Jun 27, 2026 12:33 UTC
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Obesity's secret impact on labor revealed in new study
Knowledge-focused CompletedThe purpose of this study is to improve the understanding of cellular mecanism involved in delivery disorders in obese women, first by characterizing the hyperplasia phenomenon of myometrail cells induced by inflammatory stimulation (Il-1B), then by studying the role of blood mon…
Sponsor: Centre Hospitalier Universitaire Dijon • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:03 UTC
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15,000 patient records to reveal which chronic pain treatments really work
Knowledge-focused Recruiting nowThis study will evaluate de-identified (anonymous) data in subject medical charts to review the clinical outcomes of various treatment approaches in the treatment of chronic pain.
Sponsor: Boston Scientific Corporation • Aim: Knowledge-focused
Last updated Sep 06, 2026 00:00 UTC
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Sarcoma lung surveillance study halted early: x-ray vs CT debate unresolved
Knowledge-focused Stopped earlyCancer surveillance has a significant cost and generate anxiety for the patient. It is important to avoid exams that will not modify health support or whose results wont allow to decide.
Phase 2 • Sponsor: Centre Oscar Lambret • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:02 UTC
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Hidden gene mutations may explain some adrenal gland lumps
Knowledge-focused CompletedAs the investigators observed a case of glucocorticoid mutation revealed by incidentally discovered bilateral adrenal nodular hyperplasia, it was postulated that this molecular anormality could be more frequent than previously described. To validate this hypothesis, it was decide…
Sponsor: CHU de Reims • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:12 UTC
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Pedaling while dialyzing: a simple exercise to save limbs?
Symptom relief CompletedChronic kidney disease (CKD) is associated with high level of peripheral arterial disease (PAD). This could lead wounds, infections then amputations or deaths by impairment of the peripheral cutaneous perfusion. Medical therapies are presently unable to cure, but only slow down t…
Sponsor: Hospices Civils de Lyon • Aim: Symptom relief
Last updated Jun 27, 2026 08:05 UTC
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Dialysis showdown: which method cleans blood better in ICU patients?
Disease control CompletedThe primary objective of this study is to compare the efficacity of hemodiafiltration and hemofiltration for decreasing plasma urea at 12h among intensive care patients. Secondary objectives include comparing urea clearance, filter duration, and %down-time, between the two techni…
Sponsor: Centre Hospitalier Universitaire de Nīmes • Aim: Disease control
Last updated Jun 27, 2026 07:58 UTC
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New imaging tracer could reveal hidden tumor hypoxia in prostate cancer
Knowledge-focused CompletedThe purpose of this study is to look for low levels of oxygen (hypoxia) in prostate cancer using a special x-ray test called a positron emission tomography (PET)scan. Hypoxia may have an effect on how prostate cancer grows and responds to treatments like radiotherapy and chemothe…
Sponsor: University Health Network, Toronto • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:10 UTC
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Can nicotine lozenges and E-Cigs protect kids from secondhand smoke?
Disease control CompletedThe overall aim of the current study is to determine if the use of nicotine containing products by caregivers who smoke and who are not interested in quitting, is effective in reducing children's secondhand smoke exposure.
Sponsor: University of Oklahoma • Aim: Disease control
Last updated Jun 27, 2026 12:04 UTC
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Tight spot in esophagus may signal advanced cancer
Knowledge-focused CompletedThe primary objective of this study is to document all cases of EUS in patients with esophageal cancer and determine if the inability to advance the gastroscope beyond the tumor correlates with locally advanced disease stage at Endoscopic Ultrasound.
Sponsor: AdventHealth • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:57 UTC