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127005 trials found · Page 5704 of 6351
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Which burst abdomen repair works best? new study investigates
Knowledge-focused CompletedThe goal of this observational study is to learn about the long-term effects of repair of burst abdomen by both primary repair and component separation. The main question it aims to answer is: Does component separation lower postoperative complications ?
Sponsor: Zagazig University • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:57 UTC
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Liver transplant survival: does Donor-Recipient gender matter?
Knowledge-focused CompletedThis observational study aims to investigate the impact of gender disparity between donors and recipients on long-term outcomes after liver transplantation (LT). The study aims to answer the following question: Does gender mismatch lower the possibility of survival after liver t…
Sponsor: University of Jena • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:04 UTC
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Could a common Alzheimer's drug help stroke survivors move again?
Symptom relief OngoingThis will be a randomized double blind placebo-controlled pilot study using a repeated measures design in which participants with acute ischemic stroke and upper extremity weakness are randomized to either drug or placebo
Early phase 1 • Sponsor: University of Utah • Aim: Symptom relief
Last updated Aug 29, 2026 00:00 UTC
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Can a simple dye test spot kidney trouble in the ICU?
Diagnosis CompletedThe objective of this study is to assess the feasibility of estimating the clearance of iohexol as an indirect measure of glomerular filtration rate in patients with unstable renal function in the intensive care unit through analysis of rich iohexol plasma kinetics.
Phase 3 • Sponsor: University Hospital, Tours • Aim: Diagnosis
Last updated Jun 27, 2026 08:06 UTC
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New combo pill plus insulin shows promise for type 2 diabetes
Disease control CompletedThe purpose of this study is to evaluate the efficacy and safety of Teneligliptin in combination with Insulin in patients with type 2 Diabetes for 16 weeks administration and to evaluate the safety and efficacy of Teneligliptin in combination with Insulin with an extension treatm…
Phase 4 • Sponsor: Tanabe Pharma Corporation • Aim: Disease control
Last updated Jun 27, 2026 08:08 UTC
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Can your immune system predict a c. diff relapse?
Knowledge-focused CompletedClostridium difficile is responsible for up to 25% of reported antibiotic associated diarrhea cases and virtually all cases of pseudomembranous colitis (PMC). The clinical spectrum of C. difficile infection (CDI) varies in severity from asymptomatic carriage to self-limited, mild…
Sponsor: Hospices Civils de Lyon • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:05 UTC
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Blood marker may predict prostate cancer drug response
Knowledge-focused Stopped earlyThe purpose of this study is to investigate cleavage products of the urokinase plasminogenactivator receptor (uPAR) in plasma from patients with castration resistant prostate cancer as a predictive marker of response to abiraterone.
Sponsor: Kristoffer Rohrberg • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:11 UTC
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Scientists launch worldwide registry to unlock rare Fat-Storage disease
Knowledge-focused Recruiting nowThis study aims to understand the state of onset of NLSD(neutral lipid storage disease) / TGCV(triglyceride deposit cardiovasculopathy) worldwide, background information of affected patients, and natural history of the disease, as well as exploring the prognostic factors and asse…
Sponsor: Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:02 UTC
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Scientists track heart changes after attack to predict failure risk
Knowledge-focused OngoingTo comprehensively characterize Left Ventricular (LV) remodeling after Myocardial Infarction (MI) in the community, study the association between patterns of remodeling and biological pathways and examine the association between the predictors of remodeling and heart failure afte…
Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:08 UTC
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Brain bleed shape may predict recovery, new study hopes to find out
Knowledge-focused Recruiting nowTo analyze the influence of early hematoma morphology on hematoma expansion, optimize the treatment plan for cerebral hemorrhage, and guide the treatment of patients with cerebral hemorrhage in combination with clinical practice.
Sponsor: The Affiliated Hospital Of Guizhou Medical University • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:02 UTC
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Massive global study maps kidney injury in sick kids
Knowledge-focused CompletedPediatric acute kidney injury (AKI) is associated with increased morbidity and mortality in critically ill patients. Currently, understanding of the epidemiology and diagnosis of AKI in children is limited by single center retrospective data and inconsistent diagnostic and strati…
Sponsor: Children's Hospital Medical Center, Cincinnati • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:00 UTC
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Two-step embryo transfer may boost IVF success rates
Knowledge-focused CompletedThe main aim of this study is to evaluate the impact and identify potential indications for sequential double embryo transfer (SEQ-ET) in couples undergoing assisted reproductive technology (ART). The study will compare live birth rates (LBR) between patients receiving SEQ-ET and…
Sponsor: Hopital Pierre Rouques - Les Bluets • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:02 UTC
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Brain wave monitor may help spot sepsis severity
Knowledge-focused Recruiting nowTo evaluate the discriminative power of BIS monitoring to classify the degree of mental state associated with the PCT graded sepsis cascade, and to assess its utility for monitoring the improvement or deterioration of sepsis.
Sponsor: Suez Canal University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
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Baby's nose bugs may predict asthma risk
Knowledge-focused OngoingThis study tests the hypothesis that an increase in pathogenic bacteria within the infant airway leads to increased airway inflammation, decreased airway function and ultimately airway obstruction throughout the first one to two years of life.
Sponsor: Indiana University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
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Ketamine may help ICU patients breathe easier on ventilators
Knowledge-focused CompletedImpairment of airway patency is a common cause of extubation failure and opioids and hypnotics can adversely affect airway patency. Ketamine, a noncompetitive antagonist of N-methyl-D-aspartate (NMDA), unlike other anesthetics activates respiratory effort and promotes bronchodila…
Sponsor: Massachusetts General Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:36 UTC
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Blood marker may flag surgery danger for seniors
Knowledge-focused CompletedThis study aims to explore the association between perioperative homocysteine (Hcy) levels and their pre-to-postoperative changes with postoperative complications and all-cause mortality in elderly patients undergoing non-cardiac surgery. Besides, the dynamic changes in Hcy level…
Sponsor: Chinese PLA General Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:31 UTC
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Can exercise fix tiny muscle blood vessels in COPD?
Knowledge-focused CompletedCOPD patients experiment a peripheral muscle dysfunction which impact their exercise tolerance and health-related quality of life. The capillary to fiber interface is reduced and impact the exercise capacity of the patients. While the muscle capillary creation in response to exer…
Sponsor: University Hospital, Montpellier • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:06 UTC
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Jawbone graft showdown: which technique works best for dental implants?
Knowledge-focused CompletedHorizontal alveolar ridge deficiencies may prevent the placement of dental implants and often require bone augmentation procedures before implant treatment. Two techniques commonly used for horizontal ridge augmentation are the Split Box Technique and the Split Bone Block Techniq…
Sponsor: Marmara University • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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Scientists explore GLUT1 protein as a diagnostic clue for rare lung tumors
Knowledge-focused CompletedLung neuroendocrine tumor (LNT) represents approximately 20% of all lung cancers. The classification of LNT relies upon morphology. Recently, in the World Health Organization (WHO) classification, Ki-67 rate has been proposed for classi fication. It is, however, known that Ki-67 …
Sponsor: Centre Hospitalier Universitaire, Amiens • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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Can early feeding behaviors predict later oral feeding trouble in tube-fed infants?
Knowledge-focused Stopped earlyFeeding that circumvents the oral cavity drastically alters the infant's feeding experience (pre, intra and post feeding) and may lead to oral feeding difficulty. It is estimated that 35 - 40% of infants exhibit oral feeding difficulty. Consequences include delayed oral feeding, …
Sponsor: Medical College of Wisconsin • Aim: Knowledge-focused
Last updated Aug 01, 2026 00:00 UTC