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127005 trials found · Page 5641 of 6351
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Brain scans reveal how imagining acupuncture may rewire pain pathways
Knowledge-focused CompletedThe aim of this proposal is to investigate brain response and connectivity changes evoked by video-guided acupuncture imagery treatment (VGAIT) and verum and sham acupuncture in healthy and patient populations to elucidate the underlying brain mechanisms of mind-body interaction,…
Sponsor: Massachusetts General Hospital • Aim: Knowledge-focused
Last updated Jul 23, 2026 00:00 UTC
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Keyhole vs open surgery for ankle instability: which works better?
Symptom relief CompletedRationale: Lateral ankle ligament injuries may be a result of ankle sprains. In 10-30% of patients with lateral ankle ligament injuries, chronic lateral ankle instability may be present. If conservative treatment fails, instability is treated surgically. Anatomic repair (also kno…
Sponsor: Gwendolyn Vuurberg • Aim: Symptom relief
Last updated Jun 27, 2026 07:53 UTC
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Early heart scans may help kidney patients live longer and delay dialysis
Knowledge-focused CompletedThis is the retrospective study regarding the association of invasive coronary angiography and time to renal replacement therapy initiation and mortality in patients with chronic kidney disease stage 4-5 who develop acute coronary syndrome.
Sponsor: Chulalongkorn University • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:01 UTC
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Eye fluid holds clues to saving sight in kids with retinoblastoma
Knowledge-focused Recruiting nowRetinoblastoma (RB) is a primary eye cancer that forms in the back of the eye of infants and toddlers. Traditionally, RB is diagnosed without a biopsy; tumor can only be studied once an eye has been surgically removed. Given this limitation, we use aqueous humor (AH), the clear …
Sponsor: Children's Hospital Los Angeles • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
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Ovarian tumor genes may reveal who needs stronger treatment
Knowledge-focused OngoingThe aim of this study is to identify different origin in carcinogenesis between serous borderline ovarian tumors presenting a. without implants, b. with non-invasive implants, c. with invasive implants and d. with micropapillary pattern. The presence of specific mutations could …
Sponsor: Universitair Ziekenhuis Brussel • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:29 UTC
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Cartoon cure? video before tonsil surgery may ease Kids' fears and pain
Symptom relief OngoingThis study aims to evaluate the effect of video-assisted preoperative education on fear, anxiety, and postoperative pain in childern undergoing tonsil surgery. Preoperative anxiety and fear are common among pediatric patients and may negatively affect postoperative outcomes. prov…
Sponsor: Istanbul University - Cerrahpasa • Aim: Symptom relief
Last updated Jun 27, 2026 12:28 UTC
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Researchers test if time to next treatment can replace survival as a cancer trial endpoint
Knowledge-focused CompletedTime to next treatment or death (TNT-D) may be a patient-relevant endpoint in patients treated with immune checkpoint inhibitors. This study investigate
Sponsor: Institut Bergonié • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:54 UTC
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Lung surgery ventilation showdown: high vs low pressure in 2,200 patients
Knowledge-focused CompletedOne-lung ventilation (OLV) with resting of the contralateral lung may be required to allow or facilitate thoracic surgery. However, OLV can result in severe hypoxemia, requiring a mechanical ventilation approach that is able to maintain adequate gas exchange, while protecting the…
Sponsor: Technische Universität Dresden • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:51 UTC
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Warm compress rival? TearCare device tested for dry eye
Symptom relief CompletedThis is a small, pilot study intended to determine the feasibility of this product.
Sponsor: Sight Sciences, Inc. • Aim: Symptom relief
Last updated Jun 27, 2026 07:54 UTC
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New monitoring methods aim to prevent paralysis after aortic surgery
Knowledge-focused CompletedDuring open surgery of a thoraco-abdominal aortic aneurysma (TAAA), diminished blood flow to the myelum can result in hypoxia, compromising proper function of the spinal cord. Intraoperatively, motor evoked potentials (MEP) are elicited to measure the functional integrity of the…
Sponsor: Maastricht University Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:52 UTC
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New study tests faster bladder checks to get women home sooner after hysterectomy
Knowledge-focused CompletedThe aim of this study is to investigate the impact of an active voiding trial compared to a passive voiding trial on time to discharge following a planned same day discharge laparoscopic hysterectomy. The investigators hypothesize that performing an active voiding trial will asse…
Sponsor: Brigham and Women's Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:00 UTC
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Heart surgery for AF: how well does it really work?
Knowledge-focused Recruiting nowCASE AF aims to describe the reality of medical care of patients in whom atrial fibrillation is treated by cardiac surgical ablation.
Sponsor: Stiftung Institut fuer Herzinfarktforschung • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:07 UTC
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Wisdom tooth study reveals key factors for a smoother recovery
Knowledge-focused CompletedThis prospective observational cohort study is designed to evaluate early postoperative complications and patient-reported satisfaction following surgical extraction of impacted mandibular third molars under local anesthesia in adult patients. Standardized surgical and postoperat…
Sponsor: Bahçeşehir University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:06 UTC
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11,000 heart patients enrolled in massive Data-Gathering study
Knowledge-focused Recruiting nowAMIPE is both a retrospective and prospective study which was designed in order to collect data of patients with acute coronary syndromes and myocardial injury and to improve the knowledge about these conditions.
Sponsor: IRCCS Azienda Ospedaliero-Universitaria di Bologna • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:00 UTC
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Could adding a second diabetes drug early save lives?
Knowledge-focused CompletedThis retrospective observational target-trial emulation uses electronic health record data from the TriNetX US Collaborative Network to compare early treatment intensification strategies in adults with obesity, type 2 diabetes, and cardiovascular-kidney-metabolic stage 2-3 who in…
Sponsor: Chung Shan Medical University • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:01 UTC
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Homeopathy for autism: small study tests if it adds benefit
Symptom relief CompletedThis study looked at whether homeopathic treatment could help children with Autism Spectrum Disorder (ASD) when used alongside regular therapies like speech and occupational therapy. Over seven years, children between the ages of 3 and 12 were divided into two groups (through com…
Phase 4 • Sponsor: Holistic Homoeopathic Clinic and Research Center • Aim: Symptom relief
Last updated Jun 27, 2026 07:58 UTC
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New antibody shows promise in early trial for tough colorectal cancer
Disease control CompletedA single-central,open-label,safety,pharmacokinetics,phase I study. Biological:Recombinant Anti-EGFr Antibody Two dose levels: Low-dose level patients received initial dose 100 mg/m2 and 4 weeks later 250 mg/m2 weekly maintenance to the disease progression or unacceptable toxicity…
Phase 1 • Sponsor: Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. • Aim: Disease control
Last updated Jun 27, 2026 12:31 UTC
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Thumb muscle workout may reduce arthritis pain
Symptom relief CompletedTo determine the effect of first dorsal interosseus (FDI) strengthening in patients with thumb carpometacarpal (CMC) osteoarthritis.
Sponsor: Massachusetts General Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 07:59 UTC
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Can blood tests predict who will do their swallowing exercises?
Knowledge-focused Recruiting nowThis trial uses blood tests and questionnaires to study how well participants with head and neck cancer that has spread to other places in the body adhere to swallowing exercises to prevent future disease. Using blood tests to study cytokines (proteins related to the immune syste…
Sponsor: M.D. Anderson Cancer Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:07 UTC
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Grape seed extract and diabetes drug tested for prostate cancer side effects
Disease control Stopped earlyThe purpose of this study is to look at the effect that the study drug OPC has on AGE levels in patients with prostate cancer.
Phase 2 • Sponsor: Medical University of South Carolina • Aim: Disease control
Last updated Jun 27, 2026 09:11 UTC