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This is an open-label, randomized, three-period crossover study evaluating the single-dose pharmacokinetics and relative bioavailability of a novel liquid metformin formulation at concentrations of 100 mg/mL and 250 mg/mL compared with immediate-release metformin tablets in healt…

The purpose of this research study is to determine if the cold-induced change in fat burning during exercise is different between females and males.

This observational clinical study aims to evaluate the HRQoL of thalassemia patients with iron overload in Greece, who are under treatment with deferasirox based on standard clinical practice.

This study will determine reference range intervals for the parameters reported by the Quantra System with the QPlus Cartridge in pediatric patients.

The Urgency, Severity, and Impact Questionnaire (USIQ) assesses urinary urgency independently of incontinence, measuring both symptom severity and its impact on quality of life. While validated in English and Hebrew populations, a Turkish version has not yet been developed. This …

Nicotine, a major toxic component of cigarette smoke, together with carbon monoxide (CO), constitutes a significant environmental exposure with systemic effects. Beyond its addictive potential, chronic nicotine exposure may induce inflammation, oxidative stress, tissue hypoxia, a…

The goal of this clinical trial utilizing a randomized crossover design)is to explore the modulating effects of different exercise environments （green parks, outdoor athletic tracks, and indoor settings) on acute responses to High-Intensity Interval Training (HIIT). It aims to de…

This study looks at how cannabis product label and marketing claims affect product perceptions, use expectancies, and use intentions among inexperienced and experienced cannabis users. Participants will answer online survey questions on their perceptions of a cannabis product adv…

This is a Phase 3, randomized, blinded, and placebo-controlled clinical trial investigating a new combination treatment for critically ill adults who have severe community-acquired pneumonia, especially if they also have sepsis or acute respiratory distress syndrome. The study a…

The goal of this observational study is to learn how people with multiple sclerosis (MS) understand, organise, and use their medicines at home. The study aims to explore how people take their prescribed and non-prescribed medicines, what challenges they experience, and whether an…

Laparoscopic surgeries require pneumoperitoneum and Trendelenburg position, which may lead to increased intracranial pressure (ICP). Optic nerve sheath diameter (ONSD) measurement via ultrasound is a non-invasive method to evaluate ICP. This prospective study aims to compare th…

The goal of this clinical simulation study is to learn if a "Digital Twin" graphical lung display reduce the mental workload of clinicians. The study also evaluates if this helps physicians diagnose and manage ventilator-related crises more effectively than standard ventilator sc…

This study aims to evaluate the effect of a video-supported flipped learning model on anxiety and skill levels of midwifery students in episiotomy education. Episiotomy is an important clinical skill in midwifery education, and the method used to teach this skill may influence st…

This prospective observational study aims to evaluate the effect of internal jugular vein catheterization on intracranial pressure using optic nerve sheath diameter (ONSD) measurements and carotid artery Doppler ultrasonography in adult patients undergoing surgery under general a…

Childhood is a critical period for the development of lifelong health behaviors, and early interventions play an essential role in promoting long-term health and preventing future health problems. This study is planned to evaluate the effect of health education on children's heal…

This randomized crossover study aims to investigate the effect of circadian timing of a standardized meal (morning versus evening consumption) on postprandial glucose response in healthy adults. Postprandial glucose will be assessed using the incremental area under the curve (iAU…

This research will be conducted using a parallel randomized controlled trial design to investigate the effects of a nursing education program grounded in Travelbe's Human-to-Human Relationship theory on willingness to work with elderly individuals, empathy levels, and communicati…

This study aims to investigate the relationship between foot arch structure and spatiotemporal gait parameters and cognitive function in older adults. Foot arch integrity will be assessed using the Navicular Drop Test, and gait performance will be evaluated using the 10-Meter Wal…

Globalization has significantly increased cultural diversity across many countries. Cultural diversity has been identified as an important factor influencing disease progression and health outcomes. Failure to provide culturally appropriate care may result in patient dissatisfact…

This is an open-label, single-dose, parallel-group study to evaluate the safety, tolerability and pharmacokinetic characteristics of LY03015 in healthy Chinese and Caucasian adult subjects. The duration of study will be around up to 42 days for each participant, including up to 1…