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116076 trials found · Page 5251 of 5804
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Scientists investigate why adrenal tumors produce hormones
Knowledge-focused CompletedThe adrenal glands, located atop the kidneys, normally produce several types of hormones. Tumors of these glands may or may not secrete hormones. It is not known what causes these tumors or why some secrete hormones and others do not. Some of the tumors are benign and confined to…
Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) • Aim: Knowledge-focused
Last updated Jul 25, 2026 00:00 UTC
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Which bypass works best? synthetic tube vs. your own vein
Disease control CompletedWhen medical treatments fail, critical ischemia of the lower limb often leads to surgery, i.e. above knee femoro popliteal bypass. This bypass can be performed either with DACRON or PTFE prosthesis or with the autologous saphenous vein. Both technics are used but they have not be…
Phase: NA • Sponsor: University Hospital, Bordeaux • Aim: Disease control
Last updated Jun 27, 2026 13:06 UTC
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Family study aims to unlock secrets of hereditary breast and ovarian cancer
Knowledge-focused CompletedIndividuals and families with known or suspected syndromes that include breast, ovarian or genetically-related cancers are enrolled in this family study, which is a syndrome-specific sub-set of the long-standing DCEG Human Genetics Program umbrella family studies protocol (78-C-0…
Sponsor: National Cancer Institute (NCI) • Aim: Knowledge-focused
Last updated Jul 19, 2026 00:00 UTC
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Arthritis sample bank aims to unlock better diagnostic tools
Knowledge-focused Recruiting nowThe objectives of this group project is to collect synovial fluid (SF) and paired sera and carry out preclinical studies to evaluate, alone or by combination testings, the potential of novel biomarkers for their prevalence and diagnostic/prognostic values in patients with arthrit…
Sponsor: Gilles Boire • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:34 UTC
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5000 volunteers help hunt for hidden cancer clues
Knowledge-focused Recruiting nowRATIONALE: Studying samples of tissue, blood, urine, stool, and other biological fluids from patients with cancer and from healthy volunteers undergoing colonoscopy or endoscopy may help doctors identify and learn more about biomarkers related to cancer. PURPOSE: This research s…
Sponsor: Vanderbilt University Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:10 UTC
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What to eat before exercise? study tests best meal for blood sugar control
Knowledge-focused CompletedThe goal of this randomized crossover trial is to evaluate the impact of meal macronutrient composition on the glycemic response following exercise in males with type 2 diabetes. The main question it aims to answer is: • Is the consumption of a glucose enriched meal associated w…
Phase: NA • Sponsor: Paul Poirier • Aim: Knowledge-focused
Last updated Jun 26, 2026 18:00 UTC
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Glutamine supplement may speed digestion in preemies
Knowledge-focused CompletedThis study investigates the effects of enterally supplied glutamine on gastric emptying, intestinal transit, age of total enteral nutrition and age at the end of hospitalisation. Forty neonates, aged at least 2 days and free of acute illness participate in a prospective, randomis…
Phase: PHASE4 • Sponsor: University Hospital, Rouen • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:02 UTC
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Second chance: new combo tackles hepatitis c in HIV patients
Disease control CompletedCombination of PEG interferon and ribavirin is the standard treatment of chronic hepatitis C. Efficacy of this treatment has never been evaluated in HCV-HIV infected patients, who have previously been treated with a first line anti-HCV treatment. The purpose of the study is to ev…
Phase: PHASE2 • Sponsor: University Hospital, Bordeaux • Aim: Disease control
Last updated Jun 27, 2026 12:33 UTC
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Kidney cancer surgery may raise risk of scrotal swelling, study suggests
Knowledge-focused CompletedThis population-based study will use provincial health administrative data to examine the risk of hospital admission for hydrocelectomy among males who underwent nephrectomy for kidney cancer, compared with males from the general population with similar baseline health characteri…
Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:05 UTC
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Kidney surgery linked to scrotum swelling? large study investigates
Knowledge-focused CompletedThis population-based study will use provincial health administrative data to examine the risk of hospital admission for hydrocelectomy among males who underwent laparoscopic pyeloplasty, compared with males from the general population with similar baseline health characteristics…
Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:05 UTC
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Could everyday chemicals affect baby Boys' development? new study investigates
Knowledge-focused CompletedWe studied prospectively the incidence of cryptorchidism in Nice area. We tightly matched each affected child (n=95) with 2 healthy controls (n=188) and assessed risk factors for cryptorchidism focussing on prenatal exposure (cord blood and maternal milk) to endocrine disruptors …
Phase: NA • Sponsor: Centre Hospitalier Universitaire de Nice • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:01 UTC
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Brain scans reveal secrets of Parkinson's and schizophrenia
Knowledge-focused CompletedThis is an in vivo positron emission tomography (PET) study of regional cerebral dopamine and blood flow in normal volunteers, persons with Parkinson s disease (both familial and sporadic), and those with schizophrenia spectrum disorders. The latter also sign consent for NIH appr…
Sponsor: National Institute of Mental Health (NIMH) • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:04 UTC
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Massive study tracks 10,000 people with addiction to uncover what really helps
Knowledge-focused Recruiting nowThe study is an open prospective cohort study. Participants are assessed at the start of their care in an addiction treatment unit using the Addiction Severity Index (ASI) and the Mini International Neuropsychiatric Interview (MINI), which are routinely conducted in these centers…
Sponsor: Centre Hospitalier Charles Perrens, Bordeaux • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:59 UTC
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Scientists track rare brain diseases to unlock clues for future treatments
Knowledge-focused Recruiting nowStudy description: This is a natural history study that will evaluate any patient with enzyme or DNA confirmed GM1 or GM2 gangliosidosis, sialidosis or galactosialidosis. Patients may be evaluated every 6 months for infantile onset disease, yearly for juvenile onset and approxim…
Sponsor: National Human Genome Research Institute (NHGRI) • Aim: Knowledge-focused
Last updated Jul 18, 2026 00:00 UTC
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91,000-Patient registry reveals how RA drugs really perform
Knowledge-focused ENROLLING_BY_INVITATIONThis prospective, non-interventional research registry is designed to study the comparative effectiveness and comparative safety of approved treatments for RA in a cohort of patients cared for by rheumatologists across North America. Secondary objectives include analyzing the epi…
Sponsor: CorEvitas • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:53 UTC
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Blood safety watch: 1,771 transfusion patients tracked for hidden infections
Knowledge-focused CompletedThis study will follow blood transfusion recipients for 6 to 9 months following transfusion to monitor the quality and safety of blood transfusion. Improved viral testing and careful donor screening in the last several years has dramatically reduced the rates of transfusion-relat…
Sponsor: National Institutes of Health Clinical Center (CC) • Aim: Knowledge-focused
Last updated Jul 18, 2026 00:00 UTC
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Blood tests could predict cancer therapy success
Knowledge-focused Recruiting nowThe purpose of this study is to measure the levels of serum proteins and other biomarkers in cancer patients and in patients suspected of having cancer. We believe that some of these markers may be useful for confirming the diagnosis or for selecting patients for specific types o…
Sponsor: Stanford University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:03 UTC
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Massive study tracks 3,000+ ACL patients to predict knee outcomes
Knowledge-focused OngoingThe purpose of this study is to determine the effect of modifiable risk factors on knee function, osteoarthritis, and re-rupture of the anterior cruciate ligament (ACL) following ACL reconstruction.
Sponsor: Vanderbilt University Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:00 UTC
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Pain clinic study reveals hidden infection dangers in epidural devices
Knowledge-focused OngoingThis retrospective observational study aims to evaluate the incidence and risk factors of infection associated with epidural catheter and port applications performed in the Pain Clinic of Mersin University Faculty of Medicine. Data from patients who underwent epidural catheter or…
Sponsor: Mesut Bakır • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:58 UTC
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Which drainage method is better for polyhydramnios?
Symptom relief CompletedTo compare the efficiency and maternal and fetal tolerance of two techniques of amnioreduction used in cases of symptomatic second and third trimester polyhydramnios: syringe manual aspiration technique (S group) and continuous suction technique (C group) set to - 250 mmHg
Phase: NA • Sponsor: Institut National de la Santé Et de la Recherche Médicale, France • Aim: Symptom relief
Last updated Jun 26, 2026 18:48 UTC