Brain scans may reveal how naltrexone works in teens with eating disorders
NCT ID NCT05509257
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether functional MRI (fMRI) brain scans can detect changes caused by a single dose of naltrexone in adolescents aged 13-21 with eating disorders involving binge eating or purging. Participants receive both naltrexone and a placebo in random order, two weeks apart, and undergo brain imaging. The goal is to see if the drug alters activity in reward-related brain regions, which could lead to a new way to measure drug effects in future studies.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Naltrexone
What this could lead to
If successful, this could provide a reliable brain-based test to measure how well opioid-blocking drugs work in eating disorders, potentially guiding future treatments.
What could go wrong
This is a very early, small study (60 participants) focused on measuring brain activity, not treating the disorder. The drug is given only once, so it cannot show long-term effects or real-world benefit.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Email: •••••@•••••
Locations
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Children's Mercy Research Institute
RECRUITINGKansas City, Missouri, 64108, United States
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