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116076 trials found · Page 5178 of 5804
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New hip implant put to the test: will it stay put?
Knowledge-focused OngoingThis study aims to evaluate long term fixation of the Mpact Double Mobility cup trough IMAGIKA technology.
Sponsor: Medacta International SA • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:52 UTC
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Which burst abdomen repair works best? new study investigates
Knowledge-focused CompletedThe goal of this observational study is to learn about the long-term effects of repair of burst abdomen by both primary repair and component separation. The main question it aims to answer is: Does component separation lower postoperative complications ?
Sponsor: Zagazig University • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:57 UTC
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Could a common Alzheimer's drug help stroke survivors move again?
Symptom relief OngoingThis will be a randomized double blind placebo-controlled pilot study using a repeated measures design in which participants with acute ischemic stroke and upper extremity weakness are randomized to either drug or placebo
Phase: EARLY_PHASE1 • Sponsor: University of Utah • Aim: Symptom relief
Last updated Jun 27, 2026 08:05 UTC
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Can a simple dye test spot kidney trouble in the ICU?
Diagnosis CompletedThe objective of this study is to assess the feasibility of estimating the clearance of iohexol as an indirect measure of glomerular filtration rate in patients with unstable renal function in the intensive care unit through analysis of rich iohexol plasma kinetics.
Phase: PHASE3 • Sponsor: University Hospital, Tours • Aim: Diagnosis
Last updated Jun 27, 2026 08:06 UTC
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Can your immune system predict a c. diff relapse?
Knowledge-focused CompletedClostridium difficile is responsible for up to 25% of reported antibiotic associated diarrhea cases and virtually all cases of pseudomembranous colitis (PMC). The clinical spectrum of C. difficile infection (CDI) varies in severity from asymptomatic carriage to self-limited, mild…
Phase: NA • Sponsor: Hospices Civils de Lyon • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:05 UTC
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PET scans may predict sperm retrieval success in infertile men
Diagnosis CompletedCompare FDG PET-CT parameters between azoospermia patients having an extraction of sperm cells by positive testicular extraction and those with a negative extraction.
Phase: NA • Sponsor: University Hospital, Toulouse • Aim: Diagnosis
Last updated Jun 27, 2026 08:08 UTC
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Blood marker may predict prostate cancer drug response
Knowledge-focused TerminatedThe purpose of this study is to investigate cleavage products of the urokinase plasminogenactivator receptor (uPAR) in plasma from patients with castration resistant prostate cancer as a predictive marker of response to abiraterone.
Sponsor: Kristoffer Rohrberg • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:11 UTC
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Trauma's hidden toll: stem cell failure may explain slow recovery in elderly
Knowledge-focused Recruiting nowTraumatic injury is a leading cause of morbidity and mortality in young adults, and remains a substantial economic and health care burden. Despite decades of promising preclinical and clinical investigations in trauma, investigators understanding of these entities is still incomp…
Phase: NA • Sponsor: University of Florida • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:12 UTC
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DNA registry aims to unlock secrets of testicular cancer
Knowledge-focused Recruiting nowThis study is being done to create a registry to help us learn more about germ cell tumors (GCT) and other testicular tumors. The registry will include people with these tumors and also relatives and unrelated people without these tumors. This study will help us learn more about …
Sponsor: Memorial Sloan Kettering Cancer Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:01 UTC
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Scientists launch worldwide registry to unlock rare Fat-Storage disease
Knowledge-focused Recruiting nowThis study aims to understand the state of onset of NLSD(neutral lipid storage disease) / TGCV(triglyceride deposit cardiovasculopathy) worldwide, background information of affected patients, and natural history of the disease, as well as exploring the prognostic factors and asse…
Sponsor: Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:02 UTC
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Massive global study maps kidney injury in sick kids
Knowledge-focused CompletedPediatric acute kidney injury (AKI) is associated with increased morbidity and mortality in critically ill patients. Currently, understanding of the epidemiology and diagnosis of AKI in children is limited by single center retrospective data and inconsistent diagnostic and strati…
Sponsor: Children's Hospital Medical Center, Cincinnati • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:00 UTC
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Two-step embryo transfer may boost IVF success rates
Knowledge-focused CompletedThe main aim of this study is to evaluate the impact and identify potential indications for sequential double embryo transfer (SEQ-ET) in couples undergoing assisted reproductive technology (ART). The study will compare live birth rates (LBR) between patients receiving SEQ-ET and…
Sponsor: Hopital Pierre Rouques - Les Bluets • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:02 UTC
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Brain wave monitor may help spot sepsis severity
Knowledge-focused Recruiting nowTo evaluate the discriminative power of BIS monitoring to classify the degree of mental state associated with the PCT graded sepsis cascade, and to assess its utility for monitoring the improvement or deterioration of sepsis.
Sponsor: Suez Canal University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
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Baby's nose bugs may predict asthma risk
Knowledge-focused OngoingThis study tests the hypothesis that an increase in pathogenic bacteria within the infant airway leads to increased airway inflammation, decreased airway function and ultimately airway obstruction throughout the first one to two years of life.
Sponsor: Indiana University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
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Ketamine may help ICU patients breathe easier on ventilators
Knowledge-focused CompletedImpairment of airway patency is a common cause of extubation failure and opioids and hypnotics can adversely affect airway patency. Ketamine, a noncompetitive antagonist of N-methyl-D-aspartate (NMDA), unlike other anesthetics activates respiratory effort and promotes bronchodila…
Phase: NA • Sponsor: Massachusetts General Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:36 UTC
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Blood marker may flag surgery danger for seniors
Knowledge-focused CompletedThis study aims to explore the association between perioperative homocysteine (Hcy) levels and their pre-to-postoperative changes with postoperative complications and all-cause mortality in elderly patients undergoing non-cardiac surgery. Besides, the dynamic changes in Hcy level…
Sponsor: Chinese PLA General Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:31 UTC
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Can exercise fix tiny muscle blood vessels in COPD?
Knowledge-focused CompletedCOPD patients experiment a peripheral muscle dysfunction which impact their exercise tolerance and health-related quality of life. The capillary to fiber interface is reduced and impact the exercise capacity of the patients. While the muscle capillary creation in response to exer…
Phase: NA • Sponsor: University Hospital, Montpellier • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:06 UTC
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Scientists explore GLUT1 protein as a diagnostic clue for rare lung tumors
Knowledge-focused CompletedLung neuroendocrine tumor (LNT) represents approximately 20% of all lung cancers. The classification of LNT relies upon morphology. Recently, in the World Health Organization (WHO) classification, Ki-67 rate has been proposed for classi fication. It is, however, known that Ki-67 …
Sponsor: Centre Hospitalier Universitaire, Amiens • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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40,000 patients studied: does a simpler cancer drug dose work just as well?
Knowledge-focused CompletedNivolumab is a selective monoclonal antibody that binds to the Programmed cell Death 1 (PD-1) receptor and causes reduced tumor growth. It is currently approved in France in many indications. The firsts therapeutics indications validated by the French health authorities from 2015…
Sponsor: Nantes University Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:03 UTC
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Could a tiny surgical patch preserve your voice after thyroid removal?
Symptom relief CompletedThis randomized controlled trial evaluated whether placement of oxidized regenerated cellulose (ORC) over the recurrent laryngeal nerves during total thyroidectomy affects early postoperative voice quality. Patients undergoing bilateral total thyroidectomy for benign or malignant…
Phase: NA • Sponsor: Ankara University • Aim: Symptom relief
Last updated Jul 04, 2026 00:00 UTC