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127005 trials found · Page 4905 of 6351
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New numbing technique could make hand surgery simpler and faster
Symptom relief CompletedCarpal tunnel syndrome (CTS) is a common medical condition that remains one of the most frequently reported forms of median nerve compression. Surgical procedure is a treatment option for CTS. For this surgery of the upper extremity, regional anesthesia (RA) is the strategy that …
Sponsor: CMC Ambroise Paré • Aim: Symptom relief
Last updated Jun 27, 2026 12:06 UTC
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What predicts survival in severe kidney infections? new study digs into the data
Knowledge-focused CompletedAcute obstructive pyelonephritis is a condition with a high risk of complications and may require admission to the intensive care unit. Most of the available data on this condition comes from small, retrospective, single-centre series. To date, no large-scale study has examined…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:07 UTC
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Blood and skin samples could unlock new mitochondrial disease treatments
Knowledge-focused Recruiting nowMitochondrial diseases are a genetically diverse group of disorders, some of which are caused by mutations or deletions in the mitochondrial DNA (mtDNA) and which display a wide range of severity and phenotypes. Despite a prevalence of roughly 1 in 8500 in the population there is…
Sponsor: Minovia Therapeutics Ltd. • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:52 UTC
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New breathing measure could help doctors know when to remove ventilator
Knowledge-focused Ongoingthe aim of this prospective cross-sectional study is Assessment the effectiveness of the RR/DTF in predicting successful extubation . and to Compare the effectiveness of the RR/DTF with conventional parameters (RSBI, VC, PIMAX) for predicting successful extubation All participan…
Sponsor: Eman Diaa ElDin Hassan AlHassanin • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:32 UTC
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New study investigates why some patients get worse reflux after esophagus surgery
Knowledge-focused Recruiting nowAchalasia is a neuro-degenerative disorder marked by changes in the peristalsis of the esophagus and the lack of relaxation in the lower esophageal sphincter (LES), thought to be due to damage to the myenteric plexus with an unknown cause.1 Per-oral endoscopic myotomy (POEM) is a…
Sponsor: Asian Institute of Gastroenterology, India • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:00 UTC
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Heavy periods and loose joints: a hidden connection?
Knowledge-focused Stopped earlyIn this study, researchers want to learn about the connection between heavy bleeding issues and joint hypermobility (loose joints). They want to know if these issues may indicate other connective tissue problems in girls and women with heavy menstrual bleeding who do not have a k…
Sponsor: St. Jude Children's Research Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:00 UTC
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Scientists track gut bugs in pakistani infants to unlock malnutrition mystery
Knowledge-focused OngoingChildhood malnutrition is a global public health issue with devastating consequences on the health, well-being, and psychosocial development of children. Emerging evidence suggests that malnourished children have immature gut microbiota compared to age-matched healthy controls an…
Sponsor: Khyber Medical University Peshawar • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:08 UTC
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Weekly massage eases postpartum depression and boosts function in new moms
Symptom relief CompletedPostpartum depression is a condition with high morbidity in mothers and negatively affects all family relationships. It has been observed that depression in the mother at only 2 months of age negatively affects the relationship between the baby and the mother, and that mothers wh…
Sponsor: University of Yalova • Aim: Symptom relief
Last updated Jun 27, 2026 08:05 UTC
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Finger puppets and VR games calm kids before surgery, study finds
Symptom relief OngoingThis study aims to evaluate the effect of different therapeutic play methods (finger puppet play, virtual reality glasses, and smartphone games) applied to children aged 6-12 years during the preoperative period on their anxiety levels and postoperative acute symptoms. The study …
Sponsor: Bilecik Seyh Edebali Universitesi • Aim: Symptom relief
Last updated Jun 27, 2026 08:13 UTC
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Cord blood injection could ease lower back pain
Symptom relief OngoingThis is a Phase 1 trial. The overall objective is to evaluate the safety and potential efficacy effect of specific type of umbilical cord blood product (CFL001), which, other than specific modifications in manufacturing to render it compatible with current Good Manufacturing Prac…
Phase 1 • Sponsor: University of Florida • Aim: Symptom relief
Last updated Jun 27, 2026 08:12 UTC
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Nature walks might lift your spirit: new study says yes
Symptom relief CompletedThe goal of this randomized control trial is to test if contemplating in nature could benefit spiritual well-being in general adults. The main question it aims to answer is: Does a 2-week contemplative nature intervention improve spiritual well-being? Participants in the interv…
Sponsor: University of Twente • Aim: Symptom relief
Last updated Jun 27, 2026 07:51 UTC
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Knee replacement system under Long-Term review
Knowledge-focused Recruiting nowThis study is a prospectively and retrospectively enrolled, post-market, open-label, non-randomized, single institution evaluation of clinical outcomes of primary or revision knee surgery patients who meet the eligibility criteria and received devices from the Triathlon Hinge Kne…
Sponsor: The Cleveland Clinic • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:09 UTC
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Testosterone drug JATENZO under safety spotlight for adrenal impact
Disease control OngoingTOL-CLAR-20024 is a Phase 4, multi-center, open-label safety study evaluating the potential effect of JATENZO on adrenal function in hypogonadal men treated with JATENZO for 12 months.
Phase 4 • Sponsor: Tolmar Inc. • Aim: Disease control
Last updated Jun 26, 2026 14:07 UTC
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Breast cancer survivors' brain health under microscope in new study
Knowledge-focused Recruiting nowThe purpose of this study is to look at how differences in cognitive (mental) function develop over time in breast cancer survivors compared to volunteers without a history of cancer (healthy volunteers). Both cancer survivors and healthy volunteers (who are the same age as the c…
Sponsor: Memorial Sloan Kettering Cancer Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:33 UTC
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New study tests simple way to cut Post-Surgery sore throat
Knowledge-focused CompletedThis prospective randomized controlled study evaluated the effects of different endotracheal tube cuff pressure monitoring strategies on postoperative airway complications in patients undergoing elective laparoscopic abdominal surgery under general anesthesia. Excessive endotrach…
Sponsor: Cukurova University • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:03 UTC
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Brain zaps and naps: can sound waves speed up anesthesia recovery?
Knowledge-focused CompletedThe researchers expect to gain a deeper understanding of mental function during different levels of anesthesia, and to evaluate if the use of ultrasonic brain stimulation accelerates return to consciousness. Propofol is FDA approved for use in patients undergoing an anesthetic f…
Phase 2 • Sponsor: University of Michigan • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:57 UTC
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Scientists dive deep into gut tissue to unravel childhood IBD
Knowledge-focused Recruiting nowThis is a prospective observational study collecting long-term clinical data and samples for research in pediatric inflammatory bowel disease (IBD) patients with gut inflammation and a control cohort of pediatric patients with disorders of the brain-gut interactions (DBGI) with n…
Sponsor: Seattle Children's Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
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Ultrasound tool may Fine-Tune breathing therapy in hospital patients
Knowledge-focused Recruiting nowThis study aims to evaluate the relevance of using point-of-care lung ultrasound (LUS) in modifying the physiotherapist's treatment plan for patients hospitalized in a general ward.
Sponsor: Cliniques universitaires Saint-Luc- Université Catholique de Louvain • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:25 UTC
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Could a simple amino acid boost seizure control in tough epilepsy?
Symptom relief CompletedThe main purpose of this study is to evaluate the safety and tolerability of a Leucine-Enriched Essential Amino Acid (LEAA) Powder as an add-on to a classic ketogenic diet (KD) in pediatric and adult patients with refractory epilepsy.
Phase 1 • Sponsor: Elizabeth Anne Thiele • Aim: Symptom relief
Last updated Jun 27, 2026 12:37 UTC
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New Wrinkle-Zapping device puts up a fight against Crow's feet
Symptom relief CompletedRadiofrequency (RF) devices are commonly used for noninvasive facial rejuvenation. This study compared the efficacy and safety of 10THERMA, a newly developed monopolar RF device, with those of the Thermage FLX system. To determine whether 10THERMA is noninferior to Thermage FLX i…
Sponsor: TENTECH INC. • Aim: Symptom relief
Last updated Jun 27, 2026 11:01 UTC