Could a simple amino acid boost seizure control in tough epilepsy?

NCT ID NCT06387186

Completed Symptom relief Sponsor: Elizabeth Anne Thiele Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This small study tested a leucine-enriched amino acid powder given alongside a classic ketogenic diet in 4 people with drug-resistant epilepsy. The main goal was to see if the powder is safe and tolerable. Researchers also checked if it helped with nutrition. Because it was a very early, single-arm trial with no placebo group, it can only hint at possible benefits.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Leucine-enriched essential amino acid powder
What this could lead to: If it works, this could point toward a safe way to improve seizure control and nutrition for people with drug-resistant epilepsy who are already on a ketogenic diet.
What could go wrong: This is a very early, tiny study with only 4 participants and no comparison group. It only looks at safety, not whether seizures actually improve. Results may not apply to others.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Drug Resistant Epilepsy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DRUG-RESISTANT EPILEPSY REFRACTORY EPILEPSY

Contacts and locations

Locations

Massachusetts General Hospital

Boston, Massachusetts, 02114, United States

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