Targeted drug trial aims to starve advanced cancers by blocking their DNA repair
NCT ID NCT04550494
Summary
This study is testing whether the drug talazoparib can help control advanced cancers in patients whose tumors have specific genetic mutations that affect how cells repair damaged DNA. The trial will enroll about 36 adults with various advanced solid tumors (like breast, ovarian, prostate, pancreatic, or gastric cancer) who have these mutations and whose disease has progressed after standard treatments. Researchers aim to see if the drug works by blocking a key DNA repair protein in cancer cells, potentially causing them to die, and to learn if patients can benefit from trying different drugs in this class one after another.
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Contacts and locations
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Locations
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National Cancer Institute Developmental Therapeutics Clinic
RECRUITINGBethesda, Maryland, 20892, United States
Contact
Contact Phone: •••-•••-••••
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National Institutes of Health Clinical Center
ACTIVE_NOT_RECRUITINGBethesda, Maryland, 20892, United States
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UF Health Cancer Institute - Gainesville
RECRUITINGGainesville, Florida, 32610, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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University of Oklahoma Health Sciences Center
RECRUITINGOklahoma City, Oklahoma, 73104, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Conditions
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