RECURRENT BREAST CARCINOMA

This study is testing whether the drug talazoparib can help control advanced cancers in patients whose tumors have specific genetic mutations that affect how cells repair damaged DNA. The trial will enroll about 36 adults with various advanced solid tumors (like breast, ovarian, …

This study is testing whether women with recurrent breast cancer can safely keep their breast instead of having it fully removed. It combines a smaller surgery with a second round of radiation for patients who already had radiation at least 3 years ago. The goal is to see if this…

This early-stage trial is testing a modified measles virus (MV-s-NAP) that is injected directly into tumors in patients with metastatic breast cancer. The goal is to see if the virus can safely infect and kill cancer cells while also stimulating the patient's immune system to att…

This early-stage trial is testing a new, personalized vaccine for triple-negative breast cancer (TNBC). The vaccine is custom-made from a piece of a patient's own tumor and is designed to teach their immune system to recognize and attack the cancer. Researchers are studying the v…

This study is testing whether giving a single, precise dose of radiation before a second lumpectomy can help women with recurrent breast cancer. The approach aims to shrink tumors while reducing side effects and preserving breast appearance better than traditional methods. Resear…

This study aims to protect the hearts of people with advanced HER2-positive breast cancer who are receiving a specific treatment (trastuzumab) that can sometimes damage the heart. It is observing nearly 500 patients to see how common heart problems are and testing if a common hea…

This study collects blood and tissue samples from patients with recurrent or metastatic breast cancer to create a research resource. Researchers will use these samples to better understand how breast cancer spreads and responds to treatments. The study involves 2,000 participants…