RECURRENT BREAST CARCINOMA

This early-stage study tests a personalized vaccine made from a patient's own tumor, combined with immunotherapy drugs, for triple negative breast cancer. The goal is to see if the vaccine is safe and can help the immune system attack cancer cells. About 18 adults with various st…

This study is testing a drug called talazoparib in people with advanced solid tumors that have specific DNA repair gene mutations. The goal is to see if this PARP inhibitor can shrink tumors or slow their growth, even in patients who have already tried a similar drug. About 36 ad…

This study tests a new treatment for women with a return of breast cancer after prior lumpectomy and radiation. Instead of standard radiation after surgery, patients receive a single, high-dose radiation session directly to the tumor before surgery. The goal is to shrink the tumo…

This early-stage trial tests a modified measles virus (MV-s-NAP) injected directly into tumors of people with metastatic breast cancer. The virus is designed to kill cancer cells and boost the immune system. Researchers aim to find the safest dose and see if it shrinks tumors. Ab…

This study looks at whether women whose breast cancer has returned after previous radiation can safely have breast-conserving surgery and another round of radiation instead of removing the whole breast. About 60 participants will be followed for up to 5 years to check for side ef…

This study aims to collect tumor samples and medical information from 2000 people with breast cancer that has come back or spread. Researchers will use these samples to study how the cancer changes and responds to treatments. The goal is to better understand the disease and impro…

This study looks at people with HER2+ breast cancer that has spread. All are taking trastuzumab, a targeted therapy. The main goal is to track how often heart problems occur. A smaller part of the study tests if the heart drug carvedilol can prevent these side effects.