RECURRENT OVARIAN CARCINOMA

This study is testing whether the drug talazoparib can help control advanced cancers in patients whose tumors have specific genetic mutations that affect how cells repair damaged DNA. The trial will enroll about 36 adults with various advanced solid tumors (like breast, ovarian, …

This study is testing whether adding a new immune-stimulating drug (CDX-1140) to two existing cancer drugs works better for women whose ovarian cancer has returned. About 80 participants will receive either the standard two-drug combination or the new three-drug combination, give…

This early-stage study is testing a new combination treatment for gynecologic cancers that have returned after previous therapy. Researchers are combining an oral drug called talazoparib with standard radiation therapy to see if it works better together. The main goal is to find …

This early-stage study is testing a new personalized treatment for ovarian cancer that has returned or stopped responding to standard therapies. Doctors take a patient's own immune cells, grow and train them in a lab to recognize cancer, and then infuse them back into the patient…

This trial is a large screening program that matches patients with advanced solid tumors to one of many smaller treatment studies. It uses genetic testing on a patient's tumor to find specific mutations. Patients are then assigned to a drug combination designed to target those mu…

This study is for women whose ovarian or endometrial cancer has returned or persisted despite prior treatment and has a specific genetic change (a RAS pathway mutation). It aims to see if taking two targeted drugs (selumetinib and olaparib) together works better than taking just …

This study is testing whether a personalized exercise program, guided by a Fitbit, helps patients with ovarian or endometrial cancer meet the recommended 150 minutes of weekly activity better than standard advice. It aims to see if more exercise improves quality of life, physical…

This study is testing whether taking probiotic supplements during chemotherapy can help improve gut and vaginal bacteria health in women with advanced or recurrent ovarian cancer. Researchers want to see if these supplements can reduce side effects, improve quality of life, and p…

This study is testing a new radioactive tracer used in PET/CT scans to see if it can better find and track cancer cells in people with solid tumors, including ovarian, breast, and other cancers. Researchers will inject the tracer and perform scans to see how well it highlights tu…

This study aims to understand why some people who have been treated for cancers like ovarian cancer later develop blood cancers or disorders. Researchers will observe 2,000 patients who have had certain cancer treatments to look for genetic and other risk factors. They will colle…