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One cigarette changes eye blood vessels, study finds

NCT ID NCT07261176

Knowledge-focused Sponsor: IRCCS San Raffaele Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested 40 healthy adults—20 smokers and 20 non-smokers—to see how smoking one cigarette changes blood vessels in the eye. Using special cameras, researchers measured blood vessel size and function before and after smoking. The goal was to understand the immediate effects of smoking on eye health.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
cigarette smoking (0.8 grams nicotine)
What this could lead to
If successful, this could help explain how smoking affects eye health and blood flow, possibly leading to better ways to detect early eye damage.
What could go wrong
This is a very small, early study with only 40 people. It only looks at short-term effects after one cigarette, so it cannot tell us about long-term damage or risks from smoking.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

40 people

The number who actually took part.

Started

Apr 2021

Finished

Dec 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 99 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults of both sexes (age 20 to 30 years old) * Healthy volunteers who can understand and sign informed consent * For Smokers Group: Regular daily tobacco activity (approximately 10 cigarettes per day, smoking duration 5-10 years, using cigarettes with 0.8 grams nicotine content) * For Control Group: No tobacco activity as normal life habit * Willing to abstain from tobacco activity for 24 hours prior to baseline examination * Willing to avoid vasoconstrictor substances (coffee, alcohol) prior to examinations Exclusion Criteria: * Inability to follow planned procedures * Opacity of dioptric media (lens, cornea, or vitreous) that prevents execution of examinations * Known allergies that do not allow pupillary dilation * Ocular pathologies * Systemic hypertension * Diabetes mellitus * Myopia greater than -8.0 Diopters (D) * Hyperopia greater than +5.0 D * Astigmatism greater than -3.0 D

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Smokers

Contacts and locations

Locations

  • Università Vita Salute San Raffaele

    Milan, Italy

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