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Enzyme pill eases lockjaw after wisdom tooth removal

NCT ID NCT07543146

Symptom relief Sponsor: Sharif Medical Research Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a pill called serratiopeptidase can reduce swelling and improve mouth opening after surgical removal of a lower wisdom tooth. 110 healthy adults aged 18 to 40 took part. The results compare the enzyme pill to no extra treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

110 people

The number who actually took part.

Started

Jun 2025

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 40 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: \- Patients aged 18 to 40 years. Patients requiring surgical removal of a mesioangular impacted mandibular third molar. Patients who are systemically healthy (ASA I or II). Patients willing to participate and provide written informed consent. Patients who can comply with postoperative follow-up visits. Exclusion Criteria: * Patients with systemic diseases affecting healing (e.g., diabetes, immunocompromised state). Pregnant or lactating women. Patients with known allergy or hypersensitivity to serratiopeptidase. Patients on long-term anti-inflammatory or steroid medication. Presence of acute infection at the surgical site. Patients who have taken anti-inflammatory drugs within 48 hours before surgery.

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Conditions

The condition(s) this trial relates to.

Trismus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Trismus

Contacts and locations

Locations

  • Sharif medical and dental college, jati umra.

    Lahore, Punjab Province, Pakistan

More trials for these conditions

Other studies related to the condition(s) this trial covers.